Laboratory for Viral Pathgenesis and Immunity

Department of Special Pathogens;

Subjects:

1. Analysis of the mechanisms involved in influenza virus (Flu) replication and cytopathicity.
2. Genetic engineering of recombinant Flu and NDV (rNDV).
3. Development of Pathogen Identification System by high-throughput “Next-Generation” DNA sequencer (RAPID system; collaborative work).

Published Papers

1. H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells.

   Tomo Daidoji, Takaaki Koma, Anariwa Du, Cheng-Song Yang, Mayo Ueda, Kazuyoshi Ikuta and Takaaki Nakaya

   J Virol, 82 (22), 11294-11307, 2008.
2. Metagenomic diagnosis of bacterial infections.

   Shota Nakamura, Norihiro Maeda, Ionut Mihai Miron, Myonsun Yoh, Kaori Izutsu, Chidoh Kataoka, Takeshi Honda, Teruo Yasunaga, Takaaki Nakaya, Jun Kawai, Yoshihide Hayashizaki, Toshihiro Horii and Tetsuya Iida

   Emerg Infect Dis, 14 (11), 1784-1786, 2008.
3. Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus.

   Mayo Ueda, Masanobu Yamate, Anariwa Du, Tomo Daidoji, Yoshinobu Okuno, Kazuyoshi Ikuta and Takaaki Nakaya

   Virus Res, 136 (1-2), 91-97, 2008.
4. Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length.

   Shuichi Mori, Shinya Miyake, Takayoshi Kobe, Takaaki Nakaya, Stephen D Fuller, Nobuo Kato and Kunihiro Kaihatsu

   Bioorg Med Chem Lett, 18 (14), 4249-4252, 2008.
5. Higher in vitro susceptibility of human T cells to H5N1 than H1N1 influenza viruses.

   Yong-Gang Li, Pranee Thawatsupha, Malinee Chittaganpitch, Kamonthip Rungrojcharoenkit, Gui-Mei Li, Takaaki Nakaya, Wattana Auwanit, Kazuyoshi Ikuta and Pathom Sawanpanyalert

   Biochem Biophys Res Commun, 371 (3), 484-489, 2008.
6. Reduced incorporation of SARS-CoV spike protein into viral particles due to amino acid substitutions within the receptor binding domain.

   Shu-Ming Li, Gui-Mei Li, Shota Nakamura, Kazuyoshi Ikuta and Takaaki Nakaya

   Jpn J Infect Dis, 61 (2), 123-127, 2008.

Link

http://www.biken.osaka-u.ac.jp/