Department of Signal Transduction

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Published Papers

1. Angiopoietin-1 alters tumor growth by stabilizing blood vessels or by promoting angiogenesis.

   Naoyuki Satoh, Yoshihiro Yamada, Yumi Kinugasa and Nobuyuki Takakura

   Cancer Sci, 99 (12), 2373-2379, 2008.
2. Involvement of platelet-derived growth factor receptor-beta in maintenance of mesenchyme and sensory epithelium of the neonatal mouse inner ear.

   Hisamitsu Hayashi, Takahiro Kunisada, Nobuyuki Takakura, Mitsuhiro Aoki, Keisuke Mizuta and Yatsuji Ito

   Hear Res, 245 (1-2), 73-81, 2008.
3. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1.

   Shigetomo Fukuhara, Keisuke Sako, Takashi Minami, Kazuomi Noda, Hak Zoo Kim, Tatsuhiko Kodama, Masabumi Shibuya, Nobuyuki Takakura, Gou Young Koh and Naoki Mochizuki

   Nat Cell Biol, 10 (5), 513-526, 2008.
4. Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis.

   Hiroyasu Kidoya, Masaya Ueno, Yoshihiro Yamada, Naoki Mochizuki, Mitsugu Nakata, Takashi Yano, Ryo Fujii and Nobuyuki Takakura

   EMBO J, 27 (3), 522-534, 2008.
5. Involvement of MDR1 Function In Proliferation of Tumor Cells.

   Shin-Ya Katoh, Masaya Ueno and Nobuyuki Takakura

   J Biochem, 143 (4), 517-524, 2008.

Link

http://www.biken.osaka-u.ac.jp/