Department of Molecular Protozoology

Subjects:

1. Development of a recombinant vaccine based on the malaria protein SERA.
2. Development of a novel vaccine adjuvant and elucidation of its mechanism of action.
3. Study on host-parasite interaction of malaria infection.
4. Study on phylogeny and evolution of SERA multigene family in the genus Plasmodium.

Published Papers

1. Metagenomic diagnosis of bacterial infections.

   Shota Nakamura, Norihiro Maeda, Ionut Mihai Miron, Myonsun Yoh, Kaori Izutsu, Chidoh Kataoka, Takeshi Honda, Teruo Yasunaga, Takaaki Nakaya, Jun Kawai, Yoshihide Hayashizaki, Toshihiro Horii and Tetsuya Iida

   Emerg Infect Dis, 14 (11), 1784-1786, 2008.
2. [Malaria vaccine]

   Toshihiro Horii

   Nippon Rinsho, 66 (10), 1990-1998, 2008.
3. Big bang in the evolution of extant malaria parasites.

   Toshiyuki Hayakawa, Richard Culleton, Hiroto Otani, Toshihiro Horii and Kazuyuki Tanabe

   Mol Biol Evol, 25 (10), 2233-2239, 2008.
4. Molecular and cellular mechanisms of DNA vaccines.

   Cevayir Coban, Shohei Koyama, Fumihiko Takeshita, Shizuo Akira and Ken Ishii

   Hum Vaccin, 4 (6), 453-456, 2008.
5. Evolution and phylogeny of the heterogeneous cytosolic SSU rRNA genes in the genus Plasmodium.

   Yuriko Nishimoto, Nobuko Arisue, Satoru Kawai, Ananias A Escalante, Toshihiro Horii, Kazuyuki Tanabe and Tetsuo Hashimoto

   Mol Phylogenet Evol, 47 (1), 45-53, 2008.
6. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.

   Ken J Ishii, Tatsukata Kawagoe, Shohei Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, Osamu Takeuchi, Fumihiko Takeshita, Cevayir Coban and Shizuo Akira

   Nature, 451 (7179), 725-729, 2008.
7. Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells.

   Hajime Hisaeda, Kohhei Tetsutani, Takashi Imai, Chikako Moriya, Liping Tu, Shinjiro Hamano, Xuefeng Duan, Bin Chou, Hidekazu Ishida, Akiko Aramaki, Jianying Shen, Ken J Ishii, Cevayir Coban, Shizuo Akira, Kiyoshi Takeda, Koji Yasutomo, Motomi Torii and Kunisuke Himeno

   J Immunol, 180 (4), 2496-2503, 2008.
8. Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses.

   Himanshu Kumar, Shohei Koyama, Ken J Ishii, Taro Kawai and Shizuo Akira

   J Immunol, 180 (2), 683-687, 2008.

Link

http://www.biken.osaka-u.ac.jp/