Department of Immunochemistry

Subjects:

1. Role of paired receptors on host defense.
2. Mechanism of virus entry into cells.
3. Analysis of molecules involved in host-pathogen interaction.

Published Papers

1. Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway.

   Siyuan Liang, Vladimir Ristich, Hisashi Arase, Jean Dausset, Edgardo D Carosella and Anatolij Horuzsko

   Proc Natl Acad Sci U S A, 105 (24), 8357-8362, 2008.
2. PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.

   Takeshi Satoh, Jun Arii, Tadahiro Suenaga, Jing Wang, Amane Kogure, Junji Uehori, Noriko Arase, Ikuo Shiratori, Shinya Tanaka, Yasushi Kawaguchi, Patricia G Spear, Lewis L Lanier and Hisashi Arase

   Cell, 132 (6), 935-944, 2008.
3. Bimodal regulation of T cell-mediated immune responses by TIM-4.

   Masayuki Mizui, Takashi Shikina, Hisashi Arase, Kazuhiro Suzuki, Teruhito Yasui, Paul D Rennert, Atsushi Kumanogoh and Hitoshi Kikutani

   Int Immunol, 20 (5), 695-708, 2008.
4. Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors (PILR).

   Shigekazu Tabata, Kimiko Kuroki, Jing Wang, Mizuho Kajikawa, Ikuo Shiratori, Daisuke Kohda, Hisashi Arase and Katsumi Maenaka

   J Biol Chem, 283 (14), 8893-8901, 2008.
5. An Essential Role of Sialylated O-Linked Sugar Chains in the Recognition of Mouse CD99 by Paired Ig-Like Type 2 Receptor (PILR).

   Jing Wang, Ikuo Shiratori, Takeshi Satoh, Lewis L Lanier and Hisash Arase

   J Immunol, 180 (3), 1686-1693, 2008.
6. Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRalpha).

   Shigekazu Tabata, Kimiko Kuroki, Nobuo Maita, Jing Wang, Ikuo Shiratori, Hisashi Arase, Daisuke Kohda and Katsumi Maenaka

   Acta Crystallogr Sect F Struct Biol Cryst Commun, 64 (Pt 1), 44-46, 2008.

Link

http://www.biken.osaka-u.ac.jp/