Department of Host Defense

Subjects:

1. Physiological roles of Toll-like receptor family and signaling pathways via TLRs.
2. Pathogen recognition mechanisms by innate immune system.

Published Papers

1. Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif.

   Issa Abu-Dayyeh, Marina Tiemi Shio, Shintaro Sato, Shizuo Akira, Benoit Cousineau and Martin Olivier

   PLoS Negl Trop Dis, 2 (12), e305, 2008.
2. Toll-like receptor and RIG-I-like receptor signaling.

   Taro Kawai and Shizuo Akira

   Ann N Y Acad Sci, 1143, 1-20, 2008.
3. MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.

   Timothy Sheahan, Thomas E Morrison, William Funkhouser, Satoshi Uematsu, Shizou Akira, Ralph S Baric and Mark T Heise

   PLoS Pathog, 4 (12), e1000240, 2008.
4. Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.

   Hiroyuki Saiga, Junichi Nishimura, Hirotaka Kuwata, Megumi Okuyama, Sohkichi Matsumoto, Shintaro Sato, Makoto Matsumoto, Shizuo Akira, Yasunobu Yoshikai, Kenya Honda, Masahiro Yamamoto and Kiyoshi Takeda

   J Immunol, 181 (12), 8521-8527, 2008.
5. TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus.

   Pui Y Lee, Yutaro Kumagai, Yi Li, Osamu Takeuchi, Hideo Yoshida, Jason Weinstein, Erinn S Kellner, Dina Nacionales, Tolga Barker, Kindra Kelly-Scumpia, Nico van Rooijen, Himanshu Kumar, Taro Kawai, Minoru Satoh, Shizuo Akira and Westley H Reeves

   J Exp Med, 205 (13), 2995-3006, 2008.
6. WITHDRAWN: Immunoregulatory responses induced through TLRs and potential therapeutic implications for autoimmune diseases.

   Aude Aumeunier, Françoise Grela, Emilie Bardel, Diane Damotte, Shizuo Akira, Michel Dy, Nathalie Thieblemont and Jean-François Bach

   J Autoimmun, , , 2008.
7. Toll-like receptor 7 is not necessary for retroviral neuropathogenesis but does contribute to virus-induced neuroinflammation.

   Stephanie Lewis, Niranjan Butchi, Mohammed Khaleduzzaman, Tim Morgan, Min Du, Susan Pourciau, David Baker, Shizuo Akira and Karin Peterson

   J Neurovirol, 14 (6), 492-502, 2008.
8. Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses.

   Ramanjaneyulu Allam, Rahul D Pawar, Onkar P Kulkarni, Veit Hornung, Gunter Hartmann, Stephan Segerer, Shizuo Akira, Stefan Endres and Hans-Joachim Anders

   Eur J Immunol, 38 (12), 3487-3498, 2008.
9. RIG-I-like antiviral protein in flies.

   Osamu Takeuchi and Shizuo Akira

   Nat Immunol, 9 (12), 1327-1328, 2008.
10. Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC.

    Zoe Waibler, Martina Anzaghe, Abdo Konur, Shizuo Akira, Werner Müller and Ulrich Kalinke

    Eur J Immunol, 38 (11), 3127-3137, 2008.
11. TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway.

    Ryoko Yoshida, Giichi Takaesu, Hideyuki Yoshida, Fuyuki Okamoto, Tomoko Yoshioka, Yongwon Choi, Shizuo Akira, Taro Kawai, Akihiko Yoshimura and Takashi Kobayashi

    J Biol Chem, 283 (52), 36211-36220, 2008.
12. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.

    Hendrik Poeck, Robert Besch, Cornelius Maihoefer, Marcel Renn, Damia Tormo, Svetlana Shulga Morskaya, Susanne Kirschnek, Evelyn Gaffal, Jennifer Landsberg, Johannes Hellmuth, Andreas Schmidt, David Anz, Michael Bscheider, Tobias Schwerd, Carola Berking, Carole Bourquin, Ulrich Kalinke, Elisabeth Kremmer, Hiroki Kato, Shizuo Akira, Rachel Meyers, Georg Häcker, Michael Neuenhahn, Dirk Busch, Jürgen Ruland, Simon Rothenfusser, Marco Prinz, Veit Hornung, Stefan Endres, Thomas Tüting and Gunther Hartmann

    Nat Med, 14 (11), 1256-1263, 2008.
13. Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation.

    Akio Kawakami, Mizuko Osaka, Masanori Aikawa, Satoshi Uematsu, Shizuo Akira, Peter Libby, Kentaro Shimokado, Frank M Sacks and Masayuki Yoshida

    Circ Res, 103 (12), 1402-1409, 2008.
14. Signaling flux redistribution at toll-like receptor pathway junctions.

    Kumar Selvarajoo, Yasunari Takada, Jin Gohda, Mohamed Helmy, Shizuo Akira, Masaru Tomita, Masa Tsuchiya, Jun-Ichiro Inoue and Koichi Matsuo

    PLoS ONE, 3 (10), e3430, 2008.
15. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

    Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo-Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu, Keiji Tanaka, Taro Kawai, Tohru Tsujimura, Osamu Takeuchi, Tamotsu Yoshimori and Shizuo Akira

    Nature, 456 (7219), 264-268, 2008.
16. Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.

    Qing Zhu, Colt Egelston, Aravindhan Vivekanandhan, Satoshi Uematsu, Shizuo Akira, Dennis M Klinman, Igor M Belyakov and Jay A Berzofsky

    Proc Natl Acad Sci U S A, 105 (42), 16260-16265, 2008.
17. CCAAT/Enhancer-binding Protein β Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF4.

    Hiroyuki Tominaga, Shingo Maeda, Makoto Hayashi, Shu Takeda, Shizuo Akira, Setsuro Komiya, Takashi Nakamura, Haruhiko Akiyama and Takeshi Imamura

    Mol Biol Cell, 19 (12), 5373-5386, 2008.
18. Gene-specific requirement of a nuclear protein, Ikappa B-zeta , for promoter association of inflammatory transcription regulators.

    Soh Yamazaki, Susumu Matsuo, Tatsushi Muta, Masahiro Yamamoto, Shizuo Akira and Koichiro Takeshige

    J Biol Chem, 283 (47), 32404-32411, 2008.
19. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.

    Sachie Hiratsuka, Akira Watanabe, Yoshiko Sakurai, Sachiko Akashi-Takamura, Sachie Ishibashi, Kensuke Miyake, Masabumi Shibuya, Shizuo Akira, Hiroyuki Aburatani and Yoshiro Maru

    Nat Cell Biol, 10 (11), 1349-1355, 2008.
20. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.

    Katalin Karikó, Hiromi Muramatsu, Frank A Welsh, János Ludwig, Hiroki Kato, Shizuo Akira and Drew Weissman

    Mol Ther, 16 (11), 1833-1840, 2008.
21. Innate immune response to viral infection.

    Shohei Koyama, Ken J Ishii, Cevayir Coban and Shizuo Akira

    Cytokine, 43 (3), 336-341, 2008.
22. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.

    Michael S Y Huen, Jun Huang, Jingsong Yuan, Masahiro Yamamoto, Shizuo Akira, Carolyn Ashley, Wei Xiao and Junjie Chen

    Mol Cell Biol, 28 (19), 6104-6112, 2008.
23. Lipocalin 2 is required for BCR-ABL-induced tumorigenesis.

    X Leng, H Lin, T Ding, Y Wang, Y Wu, S Klumpp, T Sun, Y Zhou, P Monaco, J Belmont, A Aderem, S Akira, R Strong and R Arlinghaus

    Oncogene, 27 (47), 6110-6119, 2008.
24. Potential link between the immune system and metabolism of nucleic acids.

    Ken J Ishii and Shizuo Akira

    Curr Opin Immunol, 20 (5), 524-529, 2008.
25. Targeted disruption of Hsp110/105 gene protects against ischemic stress.

    Junji Nakamura, Motoaki Fujimoto, Kunihiko Yasuda, Kiyoshi Takeda, Shizuo Akira, Takumi Hatayama, Yasushi Takagi, Kazuhiko Nozaki, Nobuko Hosokawa and Kazuhiro Nagata

    Stroke, 39 (10), 2853-2859, 2008.
26. Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei.

    Kiwamu Nakamura, Akiko Miyazato, Yoshinobu Koguchi, Yoshiyuki Adachi, Naohito Ohno, Shinobu Saijo, Yoichiro Iwakura, Kiyoshi Takeda, Shizuo Akira, Jiro Fujita, Keiko Ishii, Mitsuo Kaku and Kazuyoshi Kawakami

    Microbes Infect, 10 (10-11), 1223-1227, 2008.
27. Pathogen recognition by innate receptors.

    Yutaro Kumagai, Osamu Takeuchi and Shizuo Akira

    J Infect Chemother, 14 (2), 86-92, 2008.
28. TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.

    Patricia A Taylor, Michael J Ehrhardt, Christopher J Lees, Angela Panoskaltsis-Mortari, Arthur M Krieg, Arlene H Sharpe, William J Murphy, Jonathan S Serody, Hiroaki Hemmi, Shizuo Akira, Robert B Levy and Bruce R Blazar

    Blood, 112 (8), 3508-3516, 2008.
29. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury.

    Julia E Herrmann, Tetsuya Imura, Bingbing Song, Jingwei Qi, Yan Ao, Thu K Nguyen, Rose A Korsak, Kiyoshi Takeda, Shizuo Akira and Michael V Sofroniew

    J Neurosci, 28 (28), 7231-7243, 2008.
30. Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.

    Marie-Laure Santiago-Raber, Shuichi Kikuchi, Paula Borel, Satoshi Uematsu, Shizuo Akira, Brian L Kotzin and Shozo Izui

    J Immunol, 181 (2), 1556-1562, 2008.
31. Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis.

    Rie Kajino-Sakamoto, Maiko Inagaki, Elisabeth Lippert, Shizuo Akira, Sylvie Robine, Kunihiro Matsumoto, Christian Jobin and Jun Ninomiya-Tsuji

    J Immunol, 181 (2), 1143-1152, 2008.
32. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.

    Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, Reiko Hirai, Tomoji Kawai, Kazufumi Matsushita, Akane Hiiragi, Terence S Dermody, Takashi Fujita and Shizuo Akira

    J Exp Med, 205 (7), 1601-1610, 2008.
33. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice.

    Minghui Tang, Xudong Wei, Yinshi Guo, Peter Breslin, Shubin Zhang, Shanshan Zhang, Wei Wei, Zhenbiao Xia, Manuel Diaz, Shizuo Akira and Jiwang Zhang

    J Exp Med, 205 (7), 1611-1619, 2008.
34. Host innate immune receptors and beyond: making sense of microbial infections.

    Ken J Ishii, Shohei Koyama, Atsushi Nakagawa, Cevayir Coban and Shizuo Akira

    Cell Host Microbe, 3 (6), 352-363, 2008.
35. Molecular and cellular mechanisms of DNA vaccines.

    Cevayir Coban, Shohei Koyama, Fumihiko Takeshita, Shizuo Akira and Ken Ishii

    Hum Vaccin, 4 (6), 453-456, 2008.
36. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

    Satoshi Uematsu, Kosuke Fujimoto, Myoung Ho Jang, Bo-Gie Yang, Yun-Jae Jung, Mika Nishiyama, Shintaro Sato, Tohru Tsujimura, Masafumi Yamamoto, Yoshifumi Yokota, Hiroshi Kiyono, Masayuki Miyasaka, Ken J Ishii and Shizuo Akira

    Nat Immunol, 9 (7), 769-776, 2008.
37. Physical and functional interactions between ZIP kinase and UbcH5.

    Norihiko Ohbayashi, Katsuya Okada, Shiho Kawakami, Sumihito Togi, Noriko Sato, Osamu Ikeda, Shinya Kamitani, Ryuta Muromoto, Yuichi Sekine, Taro Kawai, Shizuo Akira and Tadashi Matsuda

    Biochem Biophys Res Commun, 372 (4), 708-712, 2008.
38. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.

    Toshihiko Kobayashi, Koichiro Takahashi, Yoshinori Nagai, Takuma Shibata, Masako Otani, Shozo Izui, Shizuo Akira, Yoshiyuki Gotoh, Hiroshi Kiyono and Kensuke Miyake

    Int Immunol, 20 (7), 881-891, 2008.
39. Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.

    N Elander, J Ungerbäck, H Olsson, S Uematsu, S Akira and P Söderkvist

    Biochem Biophys Res Commun, 372 (1), 249-253, 2008.
40. Group A Streptococcus activates type I interferon production and MYD88-dependent signalling without involvement of TLR2, TLR4 and TLR9.

    Nina Gratz, Maria Siller, Barbara Schaljo, Zaid A Pirzada, Irene Gattermeier, Ivo Vojtek, Carsten J Kirschning, Hermann Wagner, Shizuo Akira, Emmanuelle Charpentier and Pavel Kovarik

    J Biol Chem, 283 (29), 19879-19887, 2008.
41. IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions.

    Takumi Koga, Hiroko Endo, Yasuhiro Miyamoto, Mutsuko Mukai, Shizuo Akira and Masahiro Inoue

    Cancer Lett, 268 (1), 82-88, 2008.
42. Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IκBζ-/- mice.

    Mayumi Ueta, Junji Hamuro, Eiichiro Ueda, Norito Katoh, Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira and Shigeru Kinoshita

    Invest Ophthalmol Vis Sci, 49 (8), 3387-3394, 2008.
43. Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

    Tatsukata Kawagoe, Shintaro Sato, Kazufumi Matsushita, Hiroki Kato, Kosuke Matsui, Yutaro Kumagai, Tatsuya Saitoh, Taro Kawai, Osamu Takeuchi and Shizuo Akira

    Nat Immunol, 9 (6), 684-691, 2008.
44. Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.

    Nicolas Zucchini, Gilles Bessou, Stephanie Traub, Scott H Robbins, Satoshi Uematsu, Shizuo Akira, Lena Alexopoulou and Marc Dalod

    J Immunol, 180 (9), 5799-5803, 2008.
45. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

    Yumiko Imai, Keiji Kuba, G Greg Neely, Rubina Yaghubian-Malhami, Thomas Perkmann, Geert van Loo, Maria Ermolaeva, Ruud Veldhuizen, Y H Connie Leung, Hongliang Wang, Haolin Liu, Yang Sun, Manolis Pasparakis, Manfred Kopf, Christin Mech, Sina Bavari, J S Malik Peiris, Arthur S Slutsky, Shizuo Akira, Malin Hultqvist, Rikard Holmdahl, John Nicholls, Chengyu Jiang, Christoph J Binder and Josef M Penninger

    Cell, 133 (2), 235-249, 2008.
46. Stat3 is required in hypothalamic Agrp/Npy neurons for normal energy homeostasis.

    Lijie Gong, Fayi Yao, Kristin Hockman, Henry H Heng, Gregory J Morton, Kiyoshi Takeda, Shizuo Akira, Malcolm J Low, Marcelo Rubinstein and Robert G Mackenzie

    Endocrinology, 149 (7), 3346-3354, 2008.
47. Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection.

    Christofer Samuelsson, Jürgen Hausmann, Henning Lauterbach, Michaela Schmidt, Shizuo Akira, Hermann Wagner, Paul Chaplin, Mark Suter, Meredith O'Keeffe and Hubertus Hochrein

    J Clin Invest, 118 (5), 1776-1784, 2008.
48. MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis.

    Takayuki Tomita, Takanori Kanai, Toshimitsu Fujii, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Teruji Totsuka, Naoya Sakamoto, Shizuo Akira and Mamoru Watanabe

    J Immunol, 180 (8), 5291-5299, 2008.
49. Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis.

    Emina Savarese, Christian Steinberg, Rahul D Pawar, Wolfgang Reindl, Shizuo Akira, Hans-Joachim Anders and Anne Krug

    Arthritis Rheum, 58 (4), 1107-1115, 2008.
50. Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction.

    Ok S Shin, Ralph R Isberg, Shizuo Akira, Satoshi Uematsu, Aruna K Behera and Linden T Hu

    Infect Immun, 76 (6), 2341-2351, 2008.
51. Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells.

    Noriyuki Hirata, Yoshiki Yanagawa, Takashi Ebihara, Tsukasa Seya, Satoshi Uematsu, Shizuo Akira, Fumie Hayashi, Kazuya Iwabuchi and Kazunori Onoé

    Mol Immunol, 45 (10), 2734-2742, 2008.
52. Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury.

    Koichi Obata, Hirokazu Katsura, Kan Miyoshi, Takashi Kondo, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Tetsuo Fukuoka, Shizuo Akira and Koichi Noguchi

    J Neurochem, 105 (6), 2249-2259, 2008.
53. [Innate immunity and tuberculosis]

    Satoshi Uematsu and Shizuo Akira

    Kekkaku, 83 (2), 101-109, 2008.
54. Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway.

    Kiwamu Nakamura, Akiko Miyazato, Gang Xiao, Masumitsu Hatta, Ken Inden, Tetsuji Aoyagi, Kohei Shiratori, Kiyoshi Takeda, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Yoshiyuki Adachi, Naohito Ohno, Kazuo Suzuki, Jiro Fujita, Mitsuo Kaku and Kazuyoshi Kawakami

    J Immunol, 180 (6), 4067-4074, 2008.
55. Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor.

    Junichi Nishimura, Hiroyuki Saiga, Shintaro Sato, Megumi Okuyama, Hisako Kayama, Hirotaka Kuwata, Sohkichi Matsumoto, Toshirou Nishida, Yoshiki Sawa, Shizuo Akira, Yasunobu Yoshikai, Masahiro Yamamoto and Kiyoshi Takeda

    J Immunol, 180 (6), 4032-4039, 2008.
56. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.

    Jonathan C Kagan, Tian Su, Tiffany Horng, Amy Chow, Shizuo Akira and Ruslan Medzhitov

    Nat Immunol, 9 (4), 361-368, 2008.
57. MDA5/RIG-I and virus recognition.

    Osamu Takeuchi and Shizuo Akira

    Curr Opin Immunol, 20 (1), 17-22, 2008.
58. Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

    Christoph Hölscher, Norbert Reiling, Ulrich E Schaible, Alexandra Hölscher, Clara Bathmann, Daniel Korbel, Insa Lenz, Tanja Sonntag, Svenja Kröger, Shizuo Akira, Horst Mossmann, Carsten J Kirschning, Hermann Wagner, Marina Freudenberg and Stefan Ehlers

    Eur J Immunol, 38 (3), 680-694, 2008.
59. TLR9 as a key receptor for the recognition of DNA.

    Yutaro Kumagai, Osamu Takeuchi and Shizuo Akira

    Adv Drug Deliv Rev, 60 (7), 795-804, 2008.
60. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.

    Ken J Ishii, Tatsukata Kawagoe, Shohei Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, Osamu Takeuchi, Fumihiko Takeshita, Cevayir Coban and Shizuo Akira

    Nature, 451 (7179), 725-729, 2008.
61. TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity.

    Binzhi Zhang, Ganesan Ramesh, Satoshi Uematsu, Shizuo Akira and W Brian Reeves

    J Am Soc Nephrol, 19 (5), 923-932, 2008.
62. Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells.

    Hajime Hisaeda, Kohhei Tetsutani, Takashi Imai, Chikako Moriya, Liping Tu, Shinjiro Hamano, Xuefeng Duan, Bin Chou, Hidekazu Ishida, Akiko Aramaki, Jianying Shen, Ken J Ishii, Cevayir Coban, Shizuo Akira, Kiyoshi Takeda, Koji Yasutomo, Motomi Torii and Kunisuke Himeno

    J Immunol, 180 (4), 2496-2503, 2008.
63. Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation.

    Yoshiteru Nakano, Etsushi Kuroda, Tomohiro Kito, Satoshi Uematsu, Shizuo Akira, Akira Yokota, Shigeru Nishizawa and Uki Yamashita

    J Neurosurg, 108 (2), 311-319, 2008.
64. Translocation of VP1686 Upregulates RhoB and Accelerates Phagocytic Activity of Macrophage Through Actin Remodeling.

    Rabindra N Bhattacharjee, Kwon-Sam Park, Xiuhao Chen, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi and Shizuo Akira

    J Microbiol Biotechnol, 18 (1), 171-175, 2008.
65. Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88.

    Gemma L Foster, Tom A Barr, Andrew J Grant, Trevelyan J McKinley, Clare E Bryant, Andrew Macdonald, David Gray, Masahiro Yamamoto, Shizuo Akira, Duncan J Maskell and Pietro Mastroeni

    Immunology, 124 (4), 469-479, 2008.
66. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity.

    Sun-Young Chang, Hye-Ran Cha, Satoshi Uematsu, Shizuo Akira, Osamu Igarashi, Hiroshi Kiyono and Mi-Na Kweon

    J Immunol, 180 (3), 1609-1618, 2008.
67. Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease.

    Matam Vijay-Kumar, Jesse D Aitken, Amrita Kumar, Andrew S Neish, Satoshi Uematsu, Shizuo Akira and Andrew T Gewirtz

    Infect Immun, 76 (3), 1276-1281, 2008.
68. Targeting dendritic cell signalling to regulate the response to immunisation.

    David Escors, Luciene Lopes, Rongtuan Lin, John Hiscott, Shizuo Akira, Roger J Davis and Mary K Collins

    Blood, 111 (6), 3050-3061, 2008.
69. Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses.

    Himanshu Kumar, Shohei Koyama, Ken J Ishii, Taro Kawai and Shizuo Akira

    J Immunol, 180 (2), 683-687, 2008.
70. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.

    Jeremy B Swann, Matthew D Vesely, Anabel Silva, Janelle Sharkey, Shizuo Akira, Robert D Schreiber and Mark J Smyth

    Proc Natl Acad Sci U S A, 105 (2), 652-656, 2008.
71. Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess.

    Werner Stenzel, Sabine Soltek, Monica Sanchez-Ruiz, Shizuo Akira, Hrvoje Miletic, Dirk Schlüter and Martina Deckert

    Am J Pathol, 172 (1), 132-145, 2008.
72. Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.

    Kiyofumi Yamakawa, Satoru Kamekura, Naohiro Kawamura, Masatomo Saegusa, Daisuke Kamei, Makoto Murakami, Ichiro Kudo, Satoshi Uematsu, Shizuo Akira, Ung-il Chung, Kozo Nakamura and Hiroshi Kawaguchi

    Arthritis Rheum, 58 (1), 172-183, 2008.
73. Activation of Cytosolic Phospholipase A2α in Resident Peritoneal Macrophages by Listeria monocytogenes Involves Listeriolysin O and TLR2.

    Shahid Noor, Howard Goldfine, Dawn E Tucker, Saritha Suram, Laurel L Lenz, Shizuo Akira, Satoshi Uematsu, Milena Girotti, Joseph V Bonventre, Kevin Breuel, David L Williams and Christina C Leslie

    J Biol Chem, 283 (8), 4744-4755, 2008.
74. Toll-Like receptors (TLRs) and their ligands.

    Satoshi Uematsu and Shizuo Akira

    Handb Exp Pharmacol, (183), 1-20, 2008.
75. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.

    Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A Hoffmann, Shizuo Akira, Michael Boutros and Jean-Marc Reichhart

    Nat Immunol, 9 (1), 97-104, 2008.
76. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.

    Shahla Abdollahi-Roodsaz, Leo A B Joosten, Marije I Koenders, Isabel Devesa, Mieke F Roelofs, Timothy R D J Radstake, Marleen Heuvelmans-Jacobs, Shizuo Akira, Martin J H Nicklin, Fátima Ribeiro-Dias and Wim B van den Berg

    J Clin Invest, 118 (1), 205-216, 2008.
77. Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPβ-deficient hematopoietic cells.

    Tadayuki Akagi, Takayuki Saitoh, James O'Kelly, Shizuo Akira, Adrian F Gombart and H Phillip Koeffler

    Blood, 111 (6), 2999-3004, 2008.
78. ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.

    Chul-Su Yang, Dong-Min Shin, Hye-Mi Lee, Ji Woong Son, Sung Joong Lee, Shizuo Akira, Marie-Anne Gougerot-Pocidalo, Jamel El-Benna, Hidenori Ichijo and Eun-Kyeong Jo

    Cell Microbiol, 10 (3), 741-754, 2008.
79. Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling.

    Nicholas S Wilson, Louise J Young, Fiona Kupresanin, Shalin H Naik, David Vremec, William R Heath, Shizuo Akira, Ken Shortman, Jeff Boyle, Eugene Maraskovsky, Gabrielle T Belz and José A Villadangos

    Immunol Cell Biol, 86 (2), 200-205, 2008.
80. Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7.

    Takahiro Sugiyama, Katsuaki Hoshino, Masuyoshi Saito, Takahiro Yano, Izumi Sasaki, Chihiro Yamazaki, Shizuo Akira and Tsuneyasu Kaisho

    Int Immunol, 20 (1), 1-9, 2008.
81. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.

    Yueh-Ming Loo, Jamie Fornek, Nanette Crochet, Gagan Bajwa, Olivia Perwitasari, Luis Martinez-Sobrido, Shizuo Akira, Michelle A Gill, Adolfo García-Sastre, Michael G Katze and Michael Gale

    J Virol, 82 (1), 335-345, 2008.
82. Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

    Andreas Jung, Hiroki Kato, Yutaro Kumagai, Himanshu Kumar, Taro Kawai, Osamu Takeuchi and Shizuo Akira

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Link

http://www.biken.osaka-u.ac.jp/