Laboratory of Genomic Research on Pathogenic Bacteria

Department of Infectious Diseases Control;

Subjects:

1. Characterization of the mechanism(s) used by bacterial pathogens to infect host organisms by identifying infection-related changes in pathogen genome expression.
2. Analysis of the mechanism(s) that lead to the emergence of new infectious diseases.
3. Investigation of the life cycles of bacterial pathogens in their natural environments.
4. Development of new methods for the rapid identification of bacterial pathogens based on genome information.

Published Papers

1. Precise region and the character of the pathogenicity island in clinical Vibrio parahaemolyticus strains.

   Tomohiko Sugiyama, Tetsuya Iida, Kaori Izutsu, Kwon-Sam Park and Takeshi Honda

   J Bacteriol, 190 (5), 1835-1837, 2008.
2. Comparative genomic analysis using microarray demonstrates a strong correlation between the presence of the 80-kilobase pathogenicity island and pathogenicity in Kanagawa phenomenon-positive Vibrio parahaemolyticus strains.

   Kaori Izutsu, Ken Kurokawa, Kosuke Tashiro, Satoru Kuhara, Tetsuya Hayashi, Takeshi Honda and Tetsuya Iida

   Infect Immun, 76 (3), 1016-1023, 2008.
3. Translocation of VP1686 Upregulates RhoB and Accelerates Phagocytic Activity of Macrophage Through Actin Remodeling.

   Rabindra N Bhattacharjee, Kwon-Sam Park, Xiuhao Chen, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi and Shizuo Akira

   J Microbiol Biotechnol, 18 (1), 171-175, 2008.
4. Identification of two translocon proteins of Vibrio parahaemolyticus type III secretion system 2.

   Toshio Kodama, Hirotaka Hiyoshi, Kazuyoshi Gotoh, Yukihiro Akeda, Shigeaki Matsuda, Kwon-Sam Park, Vlademir V Cantarelli, Tetsuya Iida and Takeshi Honda

   Infect Immun, 76 (9), 4282-4289, 2008.
5. Metagenomic diagnosis of bacterial infections.

   Shota Nakamura, Norihiro Maeda, Ionut Mihai Miron, Myonsun Yoh, Kaori Izutsu, Chidoh Kataoka, Takeshi Honda, Teruo Yasunaga, Takaaki Nakaya, Jun Kawai, Yoshihide Hayashizaki, Toshihiro Horii and Tetsuya Iida

   Emerg Infect Dis, 14 (11), 1784-1786, 2008.
6. Differential replication dynamics for large and small Vibrio chromosomes affect gene dosage, expression and location.

   Rikard Dryselius, Kaori Izutsu, Takeshi Honda and Tetsuya Iida

   BMC Genomics, 9, 559, 2008.
7. Early diagnosis of infectious diarrhea using lactoferrin, and hemoglobin markers.

   SP Voravuthikunchai, K Okada, T Iida and T Honda

   J Rapid Methods Automation Microbiol, 16, 288-298, 2008.
8. Sixty years of Vibrio parahaemolyticus research.

   T Honda, T Iida, Y Akeda and T Kodama

   Microbe, 3, 462-466, 2008.

Link

http://www.biken.osaka-u.ac.jp/