Department of Bacterial Infections

Subjects:

1. Analysis of the bacterial colonization factors and their host receptors.
2. Molecular analysis of the protein toxins produced by various enteropathogens.
3. Analysis of the structure and function of the type III secretion system and the pathogenic mechanism of its effector.
4. Genome analysis of bacterial pathogens to understand pathogenic mechanisms.

Published Papers

1. Differential replication dynamics for large and small Vibrio chromosomes affect gene dosage, expression and location.

   Rikard Dryselius, Kaori Izutsu, Takeshi Honda and Tetsuya Iida

   BMC Genomics, 9, 559, 2008.
2. Metagenomic diagnosis of bacterial infections.

   Shota Nakamura, Norihiro Maeda, Ionut Mihai Miron, Myonsun Yoh, Kaori Izutsu, Chidoh Kataoka, Takeshi Honda, Teruo Yasunaga, Takaaki Nakaya, Jun Kawai, Yoshihide Hayashizaki, Toshihiro Horii and Tetsuya Iida

   Emerg Infect Dis, 14 (11), 1784-1786, 2008.
3. [Isolation of Vibrio parahaemolyticus having new combination of O and K serotypes from traveler's diarrheal patients]

   Junko Matsuyama, Myonsun Yoh and Takeshi Honda

   Kansenshogaku Zasshi, 82 (5), 471-472, 2008.
4. Multi-gene gateway clone design for expression of multiple heterologous genes in living cells: eukaryotic clones containing two and three ORF multi-gene cassettes expressed from a single promoter.

   Yukari Sasaki, Takefumi Sone, Kazuhide Yahata, Hiroe Kishine, Junko Hotta, Jonathan D Chesnut, Takeshi Honda and Fumio Imamoto

   J Biotechnol, 136 (3-4), 103-112, 2008.
5. Identification of two translocon proteins of Vibrio parahaemolyticus type III secretion system 2.

   Toshio Kodama, Hirotaka Hiyoshi, Kazuyoshi Gotoh, Yukihiro Akeda, Shigeaki Matsuda, Kwon-Sam Park, Vlademir V Cantarelli, Tetsuya Iida and Takeshi Honda

   Infect Immun, 76 (9), 4282-4289, 2008.
6. Translocation of VP1686 Upregulates RhoB and Accelerates Phagocytic Activity of Macrophage Through Actin Remodeling.

   Rabindra N Bhattacharjee, Kwon-Sam Park, Xiuhao Chen, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi and Shizuo Akira

   J Microbiol Biotechnol, 18 (1), 171-175, 2008.
7. Comparative genomic analysis using microarray demonstrates a strong correlation between the presence of the 80-kilobase pathogenicity island and pathogenicity in Kanagawa phenomenon-positive Vibrio parahaemolyticus strains.

   Kaori Izutsu, Ken Kurokawa, Kosuke Tashiro, Satoru Kuhara, Tetsuya Hayashi, Takeshi Honda and Tetsuya Iida

   Infect Immun, 76 (3), 1016-1023, 2008.
8. Precise region and the character of the pathogenicity island in clinical Vibrio parahaemolyticus strains.

   Tomohiko Sugiyama, Tetsuya Iida, Kaori Izutsu, Kwon-Sam Park and Takeshi Honda

   J Bacteriol, 190 (5), 1835-1837, 2008.

Link

http://www.biken.osaka-u.ac.jp/