Department of Virology

Subjects:

1. Pathogenesis of human immunodeficiency virus type 1.
2. Epidemiological, virological and molecular-biological characterization of Borna disease virus.
3. Mechanism of prion-induced pathogenesis in model systems.
4. Pathogenesis of SARS-coronavirus and influenzavirus.
5. Development of rapid diagnostic tool using nearinfrared spectroscopy for viral infections.
6. Safety of blood products from contaminated viruses.

Published Papers

1. Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1.

   Takeshi Kurosu, Panjaporn Chaichana, Masanobu Yamate, Surapee Anantapreecha and Kazuyoshi Ikuta

   Biochem Biophys Res Commun, 362 (4), 1051-1056, 2007.
2. The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.

   Sanae Shoji-Kawata, Qiu Zhong, Masanori Kameoka, Yukie Iwabu, Sompong Sapsutthipas, Ronald B Luftig and Kazuyoshi Ikuta

   Virology, 368 (1), 191-204, 2007.
3. Spectroscopic diagnosis of anti-phospholipid antibodies by visible and near-infrared spectroscopy in SLE patients' plasma samples.

   Junzo Nojima, Akikazu Sakudo, Yukiko Hakariya, Hirohiko Kuratsune, Yasuyoshi Watanabe, Yuzuru Kanakura and Kazuyoshi Ikuta

   Biochem Biophys Res Commun, 362 (2), 522-524, 2007.
4. Identification of the suppressive factors for human immunodeficiency virus type-1 replication using the siRNA mini-library directed against host cellular genes.

   Masanori Kameoka, Yukiko Kitagawa, Piraporn Utachee, Piyamat Jinnopat, Panadda Dhepakson, Panasda Isarangkura-na-ayuthaya, Kenzo Tokunaga, Hironori Sato, Jun Komano, Naoki Yamamoto, Shinobu Oguchi, Yukikazu Natori and Kazuyoshi Ikuta

   Biochem Biophys Res Commun, 359 (3), 729-734, 2007.
5. Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus.

   Naohiro Ohtaki, Wataru Kamitani, Yohei Watanabe, Yohei Hayashi, Hideyuki Yanai, Kazuyoshi Ikuta and Keizo Tomonaga

   J Virol, 81 (11), 5940-5948, 2007.
6. Aberrant life cycle of human immunodeficiency virus type 1 CRF15_01B-like clinical isolates from Thailand in human CD4+ T-cell lines.

   Jiranan Warachit, Yukie Iwabu, Yong-Gang Li, Gui-Mei Li, Panasda Isarangkura, Madiha S Ibrahim, Kruavon Balachandra, Shoutaro Tsuji and Kazuyoshi Ikuta

   Microbes Infect, 9 (4), 449-459, 2007.
7. Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility.

   Yohei Watanabe, Madiha S Ibrahim, Katsuro Hagiwara, Minoru Okamoto, Wataru Kamitani, Hideyuki Yanai, Naohiro Ohtaki, Yohei Hayashi, Hiroyuki Taniyama, Kazuyoshi Ikuta and Keizo Tomonaga

   Microbes Infect, 9 (4), 417-427, 2007.
8. Variability of parvovirus B19 to inactivation by liquid heating in plasma products.

   S Hattori, M Yunoki, M Tsujikawa, T Urayama, Y Tachibana, I Yamamoto, S Yamamoto and K Ikuta

   Vox Sang, 92 (2), 121-124, 2007.
9. Prion protein gene-deficient cell lines: powerful tools for prion biology.

   Akikazu Sakudo, Takashi Onodera and Kazuyoshi Ikuta

   Microbiol Immunol, 51 (1), 1-13, 2007.
10. Lipid rafts play an important role in the early stage of severe acute respiratory syndrome-coronavirus life cycle.

    Gui-Mei Li, Yong-Gang Li, Masanobu Yamate, Shu-Ming Li and Kazuyoshi Ikuta

    Microbes Infect, 9 (1), 96-102, 2007.
11. Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line.

    Akikazu Sakudo, Izuru Nakamura, Deug-Chan Lee, Keiichi Saeki, Kazuyoshi Ikuta and Takashi Onodera

    Protein Pept Lett, 14 (1), 1-6, 2007.
12. Novel single nucleotide polymorphisms in the specific protein 1 binding site of the bovine PRNP promoter in Japanese Black cattle: impairment of its promoter activity.

    Izuru Nakamura, Guangai Xue, Akikazu Sakudo, Keiichi Saeki, Yoshitsugu Matsumoto, Kazuyoshi Ikuta and Takashi Onodera

    Intervirology, 50 (3), 190-196, 2007.
13. Recent developments in prion disease research: diagnostic tools and in vitro cell culture models.

    Akikazu Sakudo, Izuru Nakamura, Kazuyoshi Ikuta and Takashi Onodera

    J Vet Med Sci, 69 (4), 329-337, 2007.
14. Native state of metals in non-digested tissues by partial least squares regression analysis of visible and near-infrared spectra.

    Akikazu Sakudo, Etsuro Yoshimura, Roumiana Tsenkova, Kazuyoshi Ikuta and Takashi Onodera

    J Toxicol Sci, 32 (2), 135-141, 2007.

Link

http://www.biken.osaka-u.ac.jp/