Department of Oncogene Research

Subjects:

1. Functional analyses of the Src family tyrosine kinases (SFK) in neural development.
2. Structural biology of SFK signaling.
3. Studies on SFK signaling in C. elegans.
4. Studies of SFK signaling in cancer cells.

Published Papers

1. C-terminal Src kinase controls development and maintenance of mouse squamous epithelia.

   Reiko Yagi, Satoshi Waguri, Yasuyuki Sumikawa, Shigeyuki Nada, Chitose Oneyama, Satoshi Itami, Christian Schmedt, Yasuo Uchiyama and Masato Okada

   EMBO J, 26 (5), 1234-1244, 2007.
2. Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.

   Vipul B Rathore, Masato Okada, Peter J Newman and Debra K Newman

   Biochem J, 403 (2), 275-281, 2007.
3. Constitutive activation of neuronal Src causes aberrant dendritic morphogenesis in mouse cerebellar Purkinje cells.

   Takenori Kotani, Nobuhiro Morone, Shigeki Yuasa, Shigeyuki Nada and Masato Okada

   Neurosci Res, 57 (2), 210-219, 2007.

Link

http://www.biken.osaka-u.ac.jp/