Department of Molecular Genetics

Subjects:

1. Molecular mechanisms regulating the cell cycle in mammalian cells.
2. Molecular mechanisms controlling the meiosis in fission yeast.
3. Molecular mechanisms modulating the metastasis of malignant cells.
4. Application of a new technique (stepwise subtraction) to RNA diagnosis.

Published Papers

1. Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26.

   Yusuke Ohba, Yukiko Kanao, Nobuyoshi Morita, Eri Fujii, Mai Hohrai, Mayuko Takatsuji, Hideki Hirose, Daisaku Miura, Akihiro Watari, Masuo Yutsudo, Hanjun Zhao, Norikazu Yabuta, Akihiko Ito, Yasuyuki Kita and Hiroshi Nojima

   Int J Cancer, 121 (1), 47-54, 2007.
2. Mcp4, a Meiotic Coiled-Coil Protein, Plays a Role in F-Actin Positioning during Schizosaccharomyces pombe Meiosis.

   Ayami Ohtaka, Daisuke Okuzaki, Takamune T Saito and Hiroshi Nojima

   Eukaryot Cell, 6 (6), 971-983, 2007.
3. Camellia oil and its distillate fractions effectively inhibit the spontaneous metastasis of mouse melanoma BL6 cells.

   Daisaku Miura, Yoshishige Kida and Hiroshi Nojima

   FEBS Lett, 581 (13), 2541-2548, 2007.
4. Lats2 is an essential mitotic regulator required for the coordination of cell division.

   Norikazu Yabuta, Nobuhiro Okada, Akihiko Ito, Toshiya Hosomi, Souichi Nishihara, Yuya Sasayama, Azumi Fujimori, Daisuke Okuzaki, Hanjun Zhao, Masahito Ikawa, Masaru Okabe and Hiroshi Nojima

   J Biol Chem, 282 (26), 19259-19271, 2007.
5. Synthesis of N-functional oleamide dervatives.

   Yusuke Ohba, Yukiko Kanao, Mayuko Takatsuji, Motoki Ito, Norikazu Yabuta, Hiroshi Nojima and Yasuyuki Kita

   Tetrahedron, 63 (18), 3754-3761, 2007.
6. Role for connexin 26 in metastasis of human malignant melanoma: communication between melanoma and endothelial cells via connexin 26.

   Mamiko Saito-Katsuragi, Hideo Asada, Hironori Niizeki, Fumitaka Katoh, Mikio Masuzawa, Masahiro Tsutsumi, Hiroki Kuniyasu, Akihiko Ito, Hiroshi Nojima and Sachiko Miyagawa

   Cancer, 110 (5), 1162-1172, 2007.
7. Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe.

   Ayami Ohtaka, Takamune T Saito, Daisuke Okuzaki and Hiroshi Nojima

   Cell Div, 2, 14, 2007.
8. Oleamide derivatives are prototypical anti-metastasis drugs that act by inhibiting connexin 26.

   Hiroshi nojima, Yusuke Ohba and Yasuyuki Kita

   Current Drug Safety, 2, 204-211, 2007.
9. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

   P Mathijs Voorhoeve, Carlos le Sage, Mariette Schrier, Ad J M Gillis, Hans Stoop, Remco Nagel, Ying-Poi Liu, Josyanne van Duijse, Jarno Drost, Alexander Griekspoor, Eitan Zlotorynski, Norikazu Yabuta, Gabriella De Vita, Hiroshi Nojima, Leendert H J Looijenga and Reuven Agami

   Adv Exp Med Biol, 604, 17-46, 2007.

Link

http://www.biken.osaka-u.ac.jp/