Department of Immunoregulation

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. Roles of GPI in microorganisms.

Published Papers

1. Both mammalian PIG-M and PIG-X are required for growth of GPI14-disrupted yeast.

   Youn Uck Kim, Hisashi Ashida, Kenichiro Mori, Yusuke Maeda, Yeongjin Hong and Taroh Kinoshita

   J Biochem (Tokyo), 142 (1), 123-129, 2007.
2. Glycolipids with nonreducing end alpha-mannosyl residues that have the potential to activate invariant Valpha19 NKT cells.

   Michio Shimamura, Yi-Ying Huang, Naoki Okamoto, Yutaka Watanabe, Yoshiko Murakami, Taroh Kinoshita, Yoshio Hirabayashi, Chikara Murakata, Yukishige Ito and Tomoya Ogawa

   FEBS J, 274 (11), 2921-2932, 2007.
3. Changes in molecular species profiles of glycosylphosphatidylinositol anchor precursors in early stages of biosynthesis.

   Toshiaki Houjou, Jun Hayakawa, Reika Watanabe, Yuko Tashima, Yusuke Maeda, Taroh Kinoshita and Ryo Taguchi

   J Lipid Res, 48 (7), 1599-1606, 2007.
4. Targeted therapy for inherited GPI deficiency.

   Antonio M Almeida, Yoshiko Murakami, Alastair Baker, Yusuke Maeda, Irene A G Roberts, Taroh Kinoshita, D Mark Layton and Anastasios Karadimitris

   N Engl J Med, 356 (16), 1641-1647, 2007.
5. Fatty acid remodeling of GPI-anchored proteins is required for their raft association.

   Yusuke Maeda, Yuko Tashima, Toshiaki Houjou, Morihisa Fujita, Takehiko Yoko-o, Yoshifumi Jigami, Ryo Taguchi and Taroh Kinoshita

   Mol Biol Cell, 18 (4), 1497-1506, 2007.
6. PGAP1 knock-out mice show otocephaly and male infertility.

   Yasutaka Ueda, Ryo Yamaguchi, Masahito Ikawa, Masaru Okabe, Eiichi Morii, Yusuke Maeda and Taroh Kinoshita

   J Biol Chem, 282 (42), 30373-30380, 2007.

Link

http://www.biken.osaka-u.ac.jp/