Department of Bacterial Infections

Subjects:

1. Analysis of the bacterial colonization factors and their host receptors.
2. Molecular analysis of the protein toxins produced by various enteropathogens.
3. Analysis of the structure and function of the type III secretion system and the pathogenic mechanism of its effector.
4. Genome analysis of bacterial pathogens to understand pathogenic mechanisms.

Published Papers

1. Demonstration and characterization of manganese superoxide dismutase of Providencia alcalifaciens.

   Xiuhao Chen, Toshio Kodama, Tetsuya Iida and Takeshi Honda

   Microbiol Immunol, 51 (10), 951-961, 2007.
2. Identification and characterization of VopT, a novel ADP-ribosyltransferase effector protein secreted via the Vibrio parahaemolyticus type III secretion system 2.

   Toshio Kodama, Mitsuhiro Rokuda, Kwon-Sam Park, Vlademir V Cantarelli, Shigeaki Matsuda, Tetsuya Iida and Takeshi Honda

   Cell Microbiol, 9 (11), 2598-2609, 2007.
3. A targeting approach for delivery of polymer microparticle-antibody conjugate against Vibrio parahaemolyticus-induced cytotoxicity to human intestinal epithelial cells.

   Feng Gao, Toshio Kodama, Xiuhao Chen, Keisaku Okada and Takeshi Honda

   J Drug Target, 15 (6), 428-436, 2007.
4. [Enterohaemorrhagic Escherichia coli infection]

   Toru Taniguchi and Takeshi Honda

   Nippon Rinsho, 65 Suppl 3, 91-97, 2007.
5. Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP.

   Vlademir V Cantarelli, Toshio Kodama, Niels Nijstad, Said Kamal Abolghait, Shigeyuki Nada, Masato Okada, Tetsuya Iida and Takeshi Honda

   Cell Microbiol, 9 (7), 1782-1795, 2007.
6. Polyclonality of Staphylococcus epidermidis residing on the healthy ocular surface.

   Mayumi Ueta, Tetsuya Iida, Masako Sakamoto, Chie Sotozono, Junko Takahashi, Kentaro Kojima, Kazuhisa Okada, Xiuhao Chen, Shigeru Kinoshita and Takeshi Honda

   J Med Microbiol, 56 (Pt 1), 77-82, 2007.
7. Lateral Transfer of the lux Gene Cluster.

   Sabu Kasai, Kazuhisa Okada, Akinori Hoshino, Tetsuya Iida and Takeshi Honda

   J Biochem (Tokyo), 141 (2), 231-237, 2007.
8. Tetrameric structure of thermostable direct hemolysin from vibrio parahaemolyticus revealed by ultracentrifugation, small-angle X-ray scattering and electron microscopy.

   Daizo Hamada, Takashi Higurashi, Kouta Mayanagi, Tomoko Miyata, Takashi Fukui, Tatsuya Iida, Takeshi Honda and Itaru Yanagihara

   J Mol Biol, 365 (1), 187-195, 2007.

Link

http://www.biken.osaka-u.ac.jp/