Department of Virology

Subjects:

1. Pathogenesis of human immunodeficiency virus type 1.
2. Epidemiological, virological and molecular-biological characterization of Borna disease virus.
3. Mechanism of prion-induced pathogenesis in model systems.
4. Pathogenesis of SARS-coronavirus and influenzavirus.
5. Development of rapid diagnostic tool using nearinfrared spectroscopy for viral infections.

Published Papers

1. Near-infrared spectroscopy: promising diagnostic tool for viral infections.

   Akikazu Sakudo, Yoshikazu Suganuma, Takanori Kobayashi, Takashi Onodera and Kazuyoshi Ikuta

   Biochem Biophys Res Commun, 341 (2), 279-284, 2006.
2. Spectroscopic diagnosis of chronic fatigue syndrome by visible and near-infrared spectroscopy in serum samples.

   Akikazu Sakudo, Hirohiko Kuratsune, Takanori Kobayashi, Seiki Tajima, Yasuyoshi Watanabe and Kazuyoshi Ikuta

   Biochem Biophys Res Commun, 345 (4), 1513-1516, 2006.
3. Recent advances in clarifying prion protein functions using knockout mice and derived cell lines.

   Akikazu Sakudo, Takashi Onodera, Yoshikazu Suganuma, Takanori Kobayashi, Keiichi Saeki and Kazuyoshi Ikuta

   Mini Rev Med Chem, 6 (5), 589-601, 2006.
4. Comparison of the vibration mode of metals in HNO3 by a partial least-squares regression analysis of near-infrared spectra.

   Akikazu Sakudo, Roumiana Tsenkova, Kyoko Tei, Taisuke Onozuka, Kazuyoshi Ikuta, Etsuro Yoshimura and Takashi Onodera

   Biosci Biotechnol Biochem, 70 (7), 1578-1583, 2006.
5. A methionine-rich domain mediates CRM1-dependent nuclear export activity of Borna disease virus phosphoprotein.

   Hideyuki Yanai, Takeshi Kobayashi, Yohei Hayashi, Yohei Watanabe, Naohiro Ohtaki, Guoqi Zhang, Juan Carlos de la Torre, Kazuyoshi Ikuta and Keizo Tomonaga

   J Virol, 80 (3), 1121-1129, 2006.
6. Development of a novel Borna disease virus reverse genetics system using RNA polymerase II promoter and SV40 nuclear import signal.

   Hideyuki Yanai, Yohei Hayashi, Yohei Watanabe, Naohiro Ohtaki, Takeshi Kobayashi, Yasutoshi Nozaki, Kazuyoshi Ikuta and Keizo Tomonaga

   Microbes Infect, 8 (6), 1522-1529, 2006.
7. Superinfection of human immunodeficiency virus type 1 (HIV-1) to cell clone persistently infected with defective virus induces production of highly cytopathogenic HIV-1.

   Yukie Iwabu, Toshiyuki Goto, Shotaro Tsuji, Jiranan Warachit, Gui-Mei Li, Sanae Shoji, Masanori Kameoka and Kazuyoshi Ikuta

   Microbes Infect, 8 (7), 1773-1782, 2006.
8. Prevalence of Borna disease virus antibodies in healthy Japanese black cattle in Kyushu.

   Yohei Watanabe, Hideyuki Yanai, Naohiro Ohtaki, Kazuyoshi Ikuta and Keizo Tomonaga

   J Vet Med Sci, 68 (2), 171-174, 2006.
9. Ex vivo tissue discrimination by visible and near-infrared spectra with chemometrics.

   Akikazu Sakudo, Roumiana Tsenkova, Kyoko Tei, Hiroyuki Morita, Kazuyoshi Ikuta and Takashi Onodera

   J Vet Med Sci, 68 (12), 1375-1378, 2006.

Link

http://www.biken.osaka-u.ac.jp/