Department of Oncogene Research

Subjects:

1. Functional analyses of the Src family tyrosine kinases (SFK) in neural development.
2. Structural biology of SFK signaling.
3. Studies on SFK signaling in C. elegans.
4. Studies of SFK signaling in cancer cells.
5. Mechanism of multi-step carcinogenesis.
6. Functional analysis of ASY/RTN4.

Published Papers

1. Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals.

   Yuko Segawa, Hiroshi Suga, Naoyuki Iwabe, Chitose Oneyama, Tsuyoshi Akagi, Takashi Miyata and Masato Okada

   Proc Natl Acad Sci U S A, 103 (32), 12021-12026, 2006.
2. Crystallization and preliminary X-ray analysis of rat SHPS-1.

   Aki Nagata, Hiroshi Ohnishi, Masato Yoshimura, Akira Ogawa, Sayuri Ujita, Hiroaki Adachi, Masato Okada, Takashi Matozaki and Atsushi Nakagawa

   Acta Crystallograph Sect F Struct Biol Cryst Commun, 62 (Pt 3), 189-191, 2006.
3. Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization.

   Naoko Kogata, Yuji Arai, James T Pearson, Kazuaki Hashimoto, Kyoko Hidaka, Tatsuya Koyama, Satoshi Somekawa, Yoshikazu Nakaoka, Minetaro Ogawa, Ralf H Adams, Masato Okada and Naoki Mochizuki

   Circ Res, 98 (7), 897-904, 2006.
4. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.

   Shigeru Hashimoto, Mayumi Hirose, Ari Hashimoto, Masaki Morishige, Atsuko Yamada, Harumi Hosaka, Ken-ichi Akagi, Eiji Ogawa, Chitose Oneyama, Tsutomu Agatsuma, Masato Okada, Hidenori Kobayashi, Hiromi Wada, Hirofumi Nakano, Takahisa Ikegami, Atsushi Nakagawa and Hisataka Sabe

   Proc Natl Acad Sci U S A, 103 (18), 7036-7041, 2006.
5. Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG.

   A Watari, K Takaki, S Higashiyama, Y Li, Y Satomi, T Takao, A Tanemura, Y Yamaguchi, I Katayama, M Shimakage, I Miyashiro, K Takami, K Kodama and M Yutsudo

   Oncogene, 25 (56), 7373-7380, 2006.
6. Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma.

   Misuzu Shimakage, Nobumasa Inoue, Kohichi Ohshima, Kunimitsu Kawahara, Takashi Oka, Kazuta Yasui, Kayoko Matsumoto, Hirokazu Inoue, Akihiro Watari, Shinji Higashiyama and Masuo Yutsudo

   Int J Cancer, 119 (7), 1648-1653, 2006.

Link

http://www.biken.osaka-u.ac.jp/