Laboratory of Malariology

Department of Infectious Diseases Control;

Subjects:

1. The evolution of antigen polymorphism in malaria parasites.
2. The origin and evolution of human malaria parasites.
3. Genetic basis of the host-specificity of malaria infecction.
4. The prevalence and population dynamics of Plasmodium vivax in Africa.

Published Papers

1. Limited allelic diversity of Plasmodium falciparum merozoite surface protein 1 gene from populations in the Solomon Islands.

   Naoko Sakihama, Hiroshi Ohmae, Bernard Bakote'e, Masato Kawabata, Kenji Hirayama and Kazuyuki Tanabe

   Am J Trop Med Hyg, 74 (1), 31-40, 2006.
2. Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections.

   Nirianne Marie Q Palacpac, Betty W Y Leung, Nobuko Arisue, Kazuyuki Tanabe, Jetsumon Sattabongkot, Takafumi Tsuboi, Motomi Torii, Rachanee Udomsangpetch and Toshihiro Horii

   Mol Biochem Parasitol, 150 (2), 353-358, 2006.
3. Rapid selection of dhfr mutant allele in Plasmodium falciparum isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guinea.

   Toshihiro Mita, Akira Kaneko, Ilomo Hwaihwanje, Takahiro Tsukahara, Nobuyuki Takahashi, Hikota Osawa, Kazuyuki Tanabe, Takatoshi Kobayakawa and Anders Björkman

   Infect Genet Evol, 6 (6), 447-452, 2006.
4. Mechanisms of drug resistance in malaria: current and new challenges.

   Pedro Cravo, Richard Culleton, Alano Afonso, Isabel D. Ferreira and Virgirio E. do Rosário

   Anti-Infective Agents in Medicinal Chemistry, 5 (1), 63-73, 2006.
5. Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution.

   Toshiyuki Hayakawa, Ikuko Aki, Ajit Varki, Yoko Satta and Naoyuki Takahata

   Genetics, 172 (2), 1139-1146, 2006.
6. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

   Takashi Angata, Toshiyuki Hayakawa, Masahiro Yamanaka, Ajit Varki and Mitsuru Nakamura

   FASEB J, 20 (12), 1964-1973, 2006.
7. System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution.

   Tasha K Altheide, Toshiyuki Hayakawa, Tarjei S Mikkelsen, Sandra Diaz, Nissi Varki and Ajit Varki

   J Biol Chem, 281 (35), 25689-25702, 2006.

Link

http://www.biken.osaka-u.ac.jp/