Department of Host Defense

Subjects:

1. Physiological roles of Toll-like receptor (TLR) family and signaling pathways via TLRs.
2. Pathogen recognition mechanisms by innate immune system.

Published Papers

1. DNA and RNA autoantigens as autoadjuvants.

   Liliana Busconi, Christina M Lau, Abigail S Tabor, Melissa B Uccellini, Zachary Ruhe, Shizuo Akira, Gregory A Viglianti, Ian R Rifkin and Ann Marshak-Rothstein

   J Endotoxin Res, 12 (6), 379-384, 2006.
2. Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling.

   Ranmal Samarasinghe, Prafullakumar Tailor, Tomohiko Tamura, Tsuneyasu Kaisho, Shizuo Akira and Keiko Ozato

   J Interferon Cytokine Res, 26 (12), 893-900, 2006.
3. IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses.

   Michishige Harada, Kumiko Magara-Koyanagi, Hiroshi Watarai, Yuko Nagata, Yasuyuki Ishii, Satoshi Kojo, Shigetoshi Horiguchi, Yoshitaka Okamoto, Toshinori Nakayama, Nobutaka Suzuki, Wen-Chen Yeh, Shizuo Akira, Hiroshi Kitamura, Osamu Ohara, Ken-ichiro Seino and Masaru Taniguchi

   J Exp Med, 203 (13), 2929-2937, 2006.
4. Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.

   Min-Kyung Choo, Noritaka Kawasaki, Pattama Singhirunnusorn, Keiichi Koizumi, Shintaro Sato, Shizuo Akira, Ikuo Saiki and Hiroaki Sakurai

   Mol Cancer Ther, 5 (12), 2970-2976, 2006.
5. Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.

   André Boonstra, Ricardo Rajsbaum, Mary Holman, Rute Marques, Carine Asselin-Paturel, João Pedro Pereira, Elizabeth E M Bates, Shizuo Akira, Paulo Vieira, Yong-Jun Liu, Giorgio Trinchieri and Anne O'Garra

   J Immunol, 177 (11), 7551-7558, 2006.
6. Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.

   Masahiro Yamamoto, Shintaro Sato, Tatsuya Saitoh, Hiroaki Sakurai, Satoshi Uematsu, Taro Kawai, Ken J Ishii, Osamu Takeuchi and Shizuo Akira

   J Immunol, 177 (11), 7520-7524, 2006.
7. Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides.

   Sandra S Diebold, Catherine Massacrier, Shizuo Akira, Carine Paturel, Yannis Morel and Caetano Reis e Sousa

   Eur J Immunol, 36 (12), 3256-3267, 2006.
8. 'Toll' gates for future immunotherapy.

   Ken J Ishii, Satoshi Uematsu and Shizuo Akira

   Curr Pharm Des, 12 (32), 4135-4142, 2006.
9. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.

   Kojiro Sato, Ayako Suematsu, Kazuo Okamoto, Akira Yamaguchi, Yasuyuki Morishita, Yuho Kadono, Sakae Tanaka, Tatsuhiko Kodama, Shizuo Akira, Yoichiro Iwakura, Daniel J Cua and Hiroshi Takayanagi

   J Exp Med, 203 (12), 2673-2682, 2006.
10. TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi.

    Ritsuko Koga, Shinjiro Hamano, Hirotaka Kuwata, Koji Atarashi, Masahiro Ogawa, Hajime Hisaeda, Masahiro Yamamoto, Shizuo Akira, Kunisuke Himeno, Makoto Matsumoto and Kiyoshi Takeda

    J Immunol, 177 (10), 7059-7066, 2006.
11. Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.

    Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi and Shizuo Akira

    J Immunol, 177 (9), 5785-5789, 2006.
12. TLR signaling.

    S Akira

    Curr Top Microbiol Immunol, 311, 1-16, 2006.
13. 5'-Triphosphate RNA is the ligand for RIG-I.

    Veit Hornung, Jana Ellegast, Sarah Kim, Krzysztof Brzózka, Andreas Jung, Hiroki Kato, Hendrik Poeck, Shizuo Akira, Karl-Klaus Conzelmann, Martin Schlee, Stefan Endres and Gunther Hartmann

    Science, 314 (5801), 994-997, 2006.
14. Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis.

    Takahisa Furuta, Takane Kikuchi, Shizuo Akira, Naohiro Watanabe and Yasuhiro Yoshikawa

    Int Immunol, 18 (12), 1655-1662, 2006.
15. The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice.

    M R Power, J S Marshall, M Yamamoto, S Akira and T-J Lin

    Clin Exp Immunol, 146 (2), 323-329, 2006.
16. Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.

    Devin D Bolz, Rhianna S Sundsbak, Ying Ma, Shizuo Akira, John H Weis, Tom G Schwan and Janis J Weis

    Infect Immun, 74 (12), 6750-6760, 2006.
17. Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.

    Barbara Albiger, Sofia Dahlberg, Andreas Sandgren, Florian Wartha, Katharina Beiter, Hiroaki Katsuragi, Shizuo Akira, Staffan Normark and Birgitta Henriques-Normark

    Cell Microbiol, 9 (3), 633-644, 2007.
18. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.

    Luisa Cervantes-Barragan, Roland Züst, Friedemann Weber, Martin Spiegel, Karl S Lang, Shizuo Akira, Volker Thiel and Burkhard Ludewig

    Blood, 109 (3), 1131-1137, 2007.
19. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

    Amal Amer, Luigi Franchi, Thirumala-Devi Kanneganti, Mathilde Body-Malapel, Nesrin Ozören, Graham Brady, Sasha Meshinchi, Rajesh Jagirdar, Andrew Gewirtz, Shizuo Akira and Gabriel Núñez

    J Biol Chem, 281 (46), 35217-35223, 2006.
20. VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.

    Rabindra N Bhattacharjee, Kwon-Sam Park, Yutaro Kumagai, Kazuhisa Okada, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi and Shizuo Akira

    J Biol Chem, 281 (48), 36897-36904, 2006.
21. Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier.

    Naohiko Shimada, Ken J Ishii, Yoichi Takeda, Cevayir Coban, Yuichi Torii, Seiji Shinkai, Shizuo Akira and Kazuo Sakurai

    Bioconjug Chem, 17 (5), 1136-1140, 2006.
22. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways.

    Dieudonnée Togbe, Gorse Aurore, Nicolas Noulin, Valérie F J Quesniaux, Silvia Schnyder-Candrian, Bruno Schnyder, Virginie Vasseur, Shizuo Akira, Kasper Hoebe, Bruce Beutler, Bernhard Ryffel and Isabelle Couillin

    Lab Invest, 86 (11), 1126-1135, 2006.
23. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response.

    Sara W Montminy, Naseema Khan, Sara McGrath, Mitchell J Walkowicz, Fiona Sharp, Joseph E Conlon, Koichi Fukase, Shoichi Kusumoto, Charles Sweet, Kensuke Miyake, Shizuo Akira, Robert J Cotter, Jon D Goguen and Egil Lien

    Nat Immunol, 7 (10), 1066-1073, 2006.
24. Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury.

    Yasushi Sakata, Jian-Wen Dong, Jesus G Vallejo, Chien-Hua Huang, J Scott Baker, Kevin J Tracey, Osamu Tacheuchi, Shizuo Akira and Douglas L Mann

    Am J Physiol Heart Circ Physiol, 292 (1), H503-509, 2007.
25. Innate immune recognition of, and regulation by, DNA.

    Ken J Ishii and Shizuo Akira

    Trends Immunol, 27 (11), 525-532, 2006.
26. Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice.

    Robert Berland, Luis Fernandez, Elina Kari, Jin-Hwan Han, Ina Lomakin, Shizuo Akira, Henry H Wortis, John F Kearney, Angelo A Ucci and Thereza Imanishi-Kari

    Immunity, 25 (3), 429-440, 2006.
27. TLR engagement prevents transplantation tolerance.

    L Chen, T Wang, P Zhou, L Ma, D Yin, J Shen, L Molinero, T Nozaki, T Phillips, S Uematsu, S Akira, C-R Wang, R L Fairchild, M-L Alegre and A Chong

    Am J Transplant, 6 (10), 2282-2291, 2006.
28. Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.

    Karl S Lang, Panco Georgiev, Mike Recher, Alexander A Navarini, Andreas Bergthaler, Mathias Heikenwalder, Nicola L Harris, Tobias Junt, Bernhard Odermatt, Pierre-Alain Clavien, Hanspeter Pircher, Shizuo Akira, Hans Hengartner and Rolf M Zinkernagel

    J Clin Invest, 116 (9), 2456-2463, 2006.
29. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.

    Shintaro Sato, Hideki Sanjo, Tohru Tsujimura, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi and Shizuo Akira

    Int Immunol, 18 (10), 1405-1411, 2006.
30. Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.

    Chul-Su Yang, Ji-Sook Lee, Chang-Hwa Song, Gang Min Hur, Sung Joong Lee, Sakae Tanaka, Shizuo Akira, Tae-Hyun Paik and Eun-Kyeong Jo

    Cell Microbiol, 9 (2), 382-396, 2007.
31. Toll-like receptors and innate immunity.

    Satoshi Uematsu and Shizuo Akira

    J Mol Med, 84 (9), 712-725, 2006.
32. TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation.

    Hokuto Kamon, Takaya Kawabe, Hidemitsu Kitamura, Jihye Lee, Daisuke Kamimura, Tsuneyasu Kaisho, Shizuo Akira, Akihiro Iwamatsu, Hisashi Koga, Masaaki Murakami and Toshio Hirano

    EMBO J, 25 (17), 4108-4119, 2006.
33. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.

    Wei-Chun Huangfu, Emily Omori, Shizuo Akira, Kunihiro Matsumoto and Jun Ninomiya-Tsuji

    J Biol Chem, 281 (39), 28802-28810, 2006.
34. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.

    Hidemitsu Kitamura, Hideyuki Morikawa, Hokuto Kamon, Megumi Iguchi, Shintaro Hojyo, Toshiyuki Fukada, Susumu Yamashita, Tsuneyasu Kaisho, Shizuo Akira, Masaaki Murakami and Toshio Hirano

    Nat Immunol, 7 (9), 971-977, 2006.
35. Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages.

    Leesun Kim, Barbara A Butcher, Chiang W Lee, Satoshi Uematsu, Shizuo Akira and Eric Y Denkers

    J Immunol, 177 (4), 2584-2591, 2006.
36. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.

    Chun-Jen Chen, Yan Shi, Arron Hearn, Kate Fitzgerald, Douglas Golenbock, George Reed, Shizuo Akira and Kenneth L Rock

    J Clin Invest, 116 (8), 2262-2271, 2006.
37. Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10.

    Todd Wuest, Bobbie Ann Austin, Satoshi Uematsu, Manoj Thapa, Shizuo Akira and Daniel J J Carr

    J Neuroimmunol, 179 (1-2), 46-52, 2006.
38. CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation.

    Ken Shirakawa, Shingo Maeda, Tomomi Gotoh, Makoto Hayashi, Kenichi Shinomiya, Shogo Ehata, Riko Nishimura, Masataka Mori, Kikuo Onozaki, Hidetoshi Hayashi, Satoshi Uematsu, Shizuo Akira, Etsuro Ogata, Kohei Miyazono and Takeshi Imamura

    Mol Cell Biol, 26 (16), 6105-6116, 2006.
39. Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.

    Yuri Ikeda-Matsuo, Azusa Ota, Tetsuya Fukada, Satoshi Uematsu, Shizuo Akira and Yasuharu Sasaki

    Proc Natl Acad Sci U S A, 103 (31), 11790-11795, 2006.
40. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.

    Masahiro Yamamoto, Toru Okamoto, Kiyoshi Takeda, Shintaro Sato, Hideki Sanjo, Satoshi Uematsu, Tatsuya Saitoh, Naoki Yamamoto, Hiroaki Sakurai, Ken J Ishii, Shoji Yamaoka, Taro Kawai, Yoshiharu Matsuura, Osamu Takeuchi and Shizuo Akira

    Nat Immunol, 7 (9), 962-970, 2006.
41. Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.

    Masaki Inada, Chiho Matsumoto, Satoshi Uematsu, Shizuo Akira and Chisato Miyaura

    J Immunol, 177 (3), 1879-1885, 2006.
42. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

    Satoshi Uematsu, Myoung Ho Jang, Nicolas Chevrier, Zijin Guo, Yutaro Kumagai, Masahiro Yamamoto, Hiroki Kato, Nagako Sougawa, Hidenori Matsui, Hirotaka Kuwata, Hiroaki Hemmi, Cevayir Coban, Taro Kawai, Ken J Ishii, Osamu Takeuchi, Masayuki Miyasaka, Kiyoshi Takeda and Shizuo Akira

    Nat Immunol, 7 (8), 868-874, 2006.
43. Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.

    Katja Fink, Karl S Lang, Nataly Manjarrez-Orduno, Tobias Junt, Beatrice M Senn, Martin Holdener, Shizuo Akira, Rolf M Zinkernagel and Hans Hengartner

    Eur J Immunol, 36 (8), 2094-2105, 2006.
44. Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1.

    Aruna K Behera, Ethan Hildebrand, Satoshi Uematsu, Shizuo Akira, Jenifer Coburn and Linden T Hu

    J Immunol, 177 (1), 657-664, 2006.
45. Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa.

    Samithamby Jeyaseelan, Scott K Young, Masahiro Yamamoto, Patrick G Arndt, Shizuo Akira, Jay K Kolls and G Scott Worthen

    J Immunol, 177 (1), 538-547, 2006.
46. Essential role of IPS-1 in innate immune responses against RNA viruses.

    Himanshu Kumar, Taro Kawai, Hiroki Kato, Shintaro Sato, Ken Takahashi, Cevayir Coban, Masahiro Yamamoto, Satoshi Uematsu, Ken J Ishii, Osamu Takeuchi and Shizuo Akira

    J Exp Med, 203 (7), 1795-1803, 2006.
47. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.

    Yoshinori Nagai, Karla P Garrett, Shoichiro Ohta, Uleng Bahrun, Taku Kouro, Shizuo Akira, Kiyoshi Takatsu and Paul W Kincade

    Immunity, 24 (6), 801-812, 2006.
48. Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity.

    Fumihiko Takeshita, Toshiyuki Tanaka, Tomoko Matsuda, Miyuki Tozuka, Kouji Kobiyama, Sukumar Saha, Kiyohiko Matsui, Ken J Ishii, Cevayir Coban, Shizuo Akira, Norihisa Ishii, Koichi Suzuki, Dennis M Klinman, Kenji Okuda and Shin Sasaki

    J Virol, 80 (13), 6218-6224, 2006.
49. TLR2 engagement on CD8 T cells lowers the thresholdfor optimal antigen-induced T cell activation.

    Anne Cottalorda, Claire Verschelde, Antoine Marçais, Martine Tomkowiak, Philippe Musette, Satoshi Uematsu, Shizuo Akira, Jacqueline Marvel and Nathalie Bonnefoy-Berard

    Eur J Immunol, 36 (7), 1684-1693, 2006.
50. Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages.

    Yuji Takahashi, Kazuto Isuzugawa, Yasunori Murase, Misa Imai, Shinya Yamamoto, Masateru Iizuka, Shizuo Akira, George M Bahr, Ei-Ichi Momotani, Masatoshi Hori, Hiroshi Ozaki and Kazuhiko Imakawa

    J Vet Med Sci, 68 (5), 471-478, 2006.
51. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.

    Takeshi Miyatsuka, Hideaki Kaneto, Toshihiko Shiraiwa, Taka-aki Matsuoka, Kaoru Yamamoto, Ken Kato, Yumiko Nakamura, Shizuo Akira, Kiyoshi Takeda, Yoshitaka Kajimoto, Yoshimitsu Yamasaki, Eric P Sandgren, Yoshiya Kawaguchi, Christopher V E Wright and Yoshio Fujitani

    Genes Dev, 20 (11), 1435-1440, 2006.
52. TLR8-mediated NFkappa B and JNK activation are TAK1-independent and MEKK3-dependent.

    Jinzhong Qin, Jianhong Yao, Grace Cui, Hui Xiao, Tae Whan Kim, Jerzy Fraczek, Paul Wightman, Shintaro Sato, Shizuo Akira, Anne Puel, Jean-Laurent Casanova, Bing Su and Xiaoxia Li

    J Biol Chem, 281 (30), 21013-21021, 2006.
53. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.

    Mihai G Netea, Leo A B Joosten, Eli Lewis, Dalan R Jensen, Peter J Voshol, Bart Jan Kullberg, Cees J Tack, Han van Krieken, Soo-Hyun Kim, Anton F Stalenhoef, Fons A van de Loo, Ineke Verschueren, Leslie Pulawa, Shizuo Akira, Robert H Eckel, Charles A Dinarello, Wim van den Berg and Jos W M van der Meer

    Nat Med, 12 (6), 650-656, 2006.
54. Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex.

    Takeshi Yoshimatsu, Daichi Kawaguchi, Koji Oishi, Kiyoshi Takeda, Shizuo Akira, Norihisa Masuyama and Yukiko Gotoh

    Development, 133 (13), 2553-2563, 2006.
55. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.

    Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, Tohru Tsujimura, Tatsusada Okuno, Kazunori Yukawa, Masayuki Mizui, Midori Yamamoto, Durbaka V R Prasad, Kazuhiro Suzuki, Masaru Ishii, Kenta Terai, Masayuki Moriya, Yuji Nakatsuji, Saburo Sakoda, Shintaro Sato, Shizuo Akira, Kiyoshi Takeda, Masanori Inui, Toshiyuki Takai, Masahito Ikawa, Masaru Okabe, Atsushi Kumanogoh and Hitoshi Kikutani

    Nat Cell Biol, 8 (6), 615-622, 2006.
56. Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans.

    Kiwamu Nakamura, Kazuya Miyagi, Yoshinobu Koguchi, Yuki Kinjo, Kaori Uezu, Takeshi Kinjo, Morikazu Akamine, Jiro Fujita, Ikuo Kawamura, Masao Mitsuyama, Yoshiyuki Adachi, Naohito Ohno, Kiyoshi Takeda, Shizuo Akira, Akiko Miyazato, Mitsuo Kaku and Kazuyoshi Kawakami

    FEMS Immunol Med Microbiol, 47 (1), 148-154, 2006.
57. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

    Tatsuya Saitoh, Adrian Tun-Kyi, Akihide Ryo, Masahiro Yamamoto, Greg Finn, Takashi Fujita, Shizuo Akira, Naoki Yamamoto, Kun Ping Lu and Shoji Yamaoka

    Nat Immunol, 7 (6), 598-605, 2006.
58. Induction of beta-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2.

    Yasuyuki Sumikawa, Hideo Asada, Katsuaki Hoshino, Hiroaki Azukizawa, Ichiro Katayama, Shizuo Akira and Satoshi Itami

    Microbes Infect, 8 (6), 1513-1521, 2006.
59. IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses.

    Carola Schellack, Karin Prinz, Alena Egyed, Jörg H Fritz, Barbara Wittmann, Michael Ginzler, Gabriele Swatosch, Wolfgang Zauner, Constantia Kast, Shizuo Akira, Alexander von Gabain, Michael Buschle and Karen Lingnau

    Vaccine, 24 (26), 5461-5472, 2006.
60. TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis.

    Emily Omori, Kunihiro Matsumoto, Hideki Sanjo, Shintaro Sato, Shizuo Akira, Robert C Smart and Jun Ninomiya-Tsuji

    J Biol Chem, 281 (28), 19610-19617, 2006.
61. Toll-like receptor function and signaling.

    Tsuneyasu Kaisho and Shizuo Akira

    J Allergy Clin Immunol, 117 (5), 979-87; quiz 988, 2006.
62. C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.

    Motoyoshi Endo, Masataka Mori, Shizuo Akira and Tomomi Gotoh

    J Immunol, 176 (10), 6245-6253, 2006.
63. "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.

    Kindra M Kelly, Haoyang Zhuang, Dina C Nacionales, Philip O Scumpia, Robert Lyons, Jun Akaogi, Pui Lee, Bryan Williams, Masahiro Yamamoto, Shizuo Akira, Minoru Satoh and Westley H Reeves

    Arthritis Rheum, 54 (5), 1557-1567, 2006.
64. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.

    Hiroki Kato, Osamu Takeuchi, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Kosuke Matsui, Satoshi Uematsu, Andreas Jung, Taro Kawai, Ken J Ishii, Osamu Yamaguchi, Kinya Otsu, Tohru Tsujimura, Chang-Sung Koh, Caetano Reis e Sousa, Yoshiharu Matsuura, Takashi Fujita and Shizuo Akira

    Nature, 441 (7089), 101-105, 2006.
65. In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells.

    S Löseke, E Grage-Griebenow, H Heine, A Wagner, S Akira, S Bauer and A Bufe

    Scand J Immunol, 63 (4), 264-274, 2006.
66. Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice.

    Mathieu Barrier, Sonia Lacroix-Lamandé, Roselyne Mancassola, Gaël Auray, Nelly Bernardet, Anne-Marie Chaussé, Satoshi Uematsu, Shizuo Akira and Fabrice Laurent

    J Infect Dis, 193 (10), 1400-1407, 2006.
67. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.

    Katsuaki Hoshino, Takahiro Sugiyama, Mitsuru Matsumoto, Takashi Tanaka, Masuyoshi Saito, Hiroaki Hemmi, Osamu Ohara, Shizuo Akira and Tsuneyasu Kaisho

    Nature, 440 (7086), 949-953, 2006.
68. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.

    Daniel C Rowe, Anne F McGettrick, Eicke Latz, Brian G Monks, Nicholas J Gay, Masahiro Yamamoto, Shizuo Akira, Luke A O'Neill, Katherine A Fitzgerald and Douglas T Golenbock

    Proc Natl Acad Sci U S A, 103 (16), 6299-6304, 2006.
69. Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice.

    Kazunori Yukawa, Tetsuji Tanaka, Tao Bai, Li Li, Yuji Tsubota, Kyoko Owada-Makabe, Masanobu Maeda, Katsuaki Hoshino, Shizuo Akira and Hiroyuki Iso

    Int J Mol Med, 17 (5), 869-873, 2006.
70. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA.

    Ken Takahashi, Taro Kawai, Himanshu Kumar, Shintaro Sato, Shin Yonehara and Shizuo Akira

    J Immunol, 176 (8), 4520-4524, 2006.
71. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.

    Hiroshi Inoue, Wataru Ogawa, Akihiro Asakawa, Yasuo Okamoto, Akihiko Nishizawa, Michihiro Matsumoto, Kiyoshi Teshigawara, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Kenji Notohara, Koji Katayose, Hitoshi Okamura, C Ronald Kahn, Tetsuo Noda, Kiyoshi Takeda, Shizuo Akira, Akio Inui and Masato Kasuga

    Cell Metab, 3 (4), 267-275, 2006.
72. Toll-like receptor 2 controls expansion and function of regulatory T cells.

    Roger P M Sutmuller, Martijn H M G M den Brok, Matthijs Kramer, Erik J Bennink, Liza W J Toonen, Bart-Jan Kullberg, Leo A Joosten, Shizuo Akira, Mihai G Netea and Gosse J Adema

    J Clin Invest, 116 (2), 485-494, 2006.
73. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.

    Noriyuki Uemura, Taisuke Kajino, Hideki Sanjo, Shintaro Sato, Shizuo Akira, Kunihiro Matsumoto and Jun Ninomiya-Tsuji

    J Biol Chem, 281 (12), 7863-7872, 2006.
74. TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides.

    Ute Buwitt-Beckmann, Holger Heine, Karl-Heinz Wiesmüller, Günther Jung, Roland Brock, Shizuo Akira and Artur J Ulmer

    J Biol Chem, 281 (14), 9049-9057, 2006.
75. Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity.

    Troy Querec, Soumaya Bennouna, Sefik Alkan, Yasmina Laouar, Keith Gorden, Richard Flavell, Shizuo Akira, Rafi Ahmed and Bali Pulendran

    J Exp Med, 203 (2), 413-424, 2006.
76. Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.

    Nicolas Lapaque, Osamu Takeuchi, Fernando Corrales, Shizuo Akira, Ignacio Moriyon, Jonathan C Howard and Jean-Pierre Gorvel

    Cell Microbiol, 8 (3), 401-413, 2006.
77. Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.

    Ping Zhu, Sung Hee Baek, Eliot M Bourk, Kenneth A Ohgi, Ivan Garcia-Bassets, Hideki Sanjo, Shizuo Akira, Paul F Kotol, Christopher K Glass, Michael G Rosenfeld and David W Rose

    Cell, 124 (3), 615-629, 2006.
78. MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi.

    Aruna K Behera, Ethan Hildebrand, Roderick T Bronson, George Perides, Satoshi Uematsu, Shizuo Akira and Linden T Hu

    Infect Immun, 74 (3), 1462-1470, 2006.
79. Pathogen recognition and innate immunity.

    Shizuo Akira, Satoshi Uematsu and Osamu Takeuchi

    Cell, 124 (4), 783-801, 2006.
80. The role of Toll-like receptors in immune disorders.

    Satoshi Uematsu and Shizuo Akira

    Expert Opin Biol Ther, 6 (3), 203-214, 2006.
81. Modifying toll-like receptor 9 signaling for therapeutic use.

    Rabindra N Bhattacharjee and Shizuo Akira

    Mini Rev Med Chem, 6 (3), 287-291, 2006.
82. IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis.

    Leilani L Santos, Georgia P Milenkovski, Pamela H Hall, Michelle Leech, Laveena Sharma, Kiyoshi Takeda, Shizuo Akira, A Richard Kitching and Eric F Morand

    Immunol Cell Biol, 84 (2), 166-173, 2006.
83. Activation of smooth muscle and myenteric plexus cells of jejunum via toll-like receptor 4.

    Cristiano Rumio, Dario Besusso, Francesca Arnaboldi, Marco Palazzo, Silvia Selleri, Silvia Gariboldi, Shizuo Akira, Satoshi Uematsu, Paola Bignami, Valerio Ceriani, Sylvie Ménard and Andrea Balsari

    J Cell Physiol, 208 (1), 47-54, 2006.
84. Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.

    Tetsuya Oshikawa, Masato Okamoto, Tomoyuki Tano, Akiko Sasai, Shin Kan, Yoichiro Moriya, Yoshiki Ryoma, Motoo Saito, Shizuo Akira and Mitsunobu Sato

    J Immunother, 29 (2), 143-150, 2006.
85. Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.

    Dan Kinoshita, Fumiko Hirota, Tsuneyasu Kaisho, Michiyuki Kasai, Keisuke Izumi, Yoshimi Bando, Yasuhiro Mouri, Akemi Matsushima, Shino Niki, Hongwei Han, Kiyotaka Oshikawa, Noriyuki Kuroda, Masahiko Maegawa, Minoru Irahara, Kiyoshi Takeda, Shizuo Akira and Mitsuru Matsumoto

    J Immunol, 176 (7), 3995-4002, 2006.
86. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

    Ken J Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi and Shizuo Akira

    Nat Immunol, 7 (1), 40-48, 2006.
87. Erratum: A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

    Ken J Ishii, Cevayir Coban, Hiroki Kato, Ken Takahashi, Yuichi Torii, Fumihiko Takeshita, Holger Ludwig, Gerd Sutter, Koichi Suzuki, Hiroaki Hemmi, Shintaro Sato, Masahiro Yamamoto, Satoshi Uematsu, Taro Kawai, Osamu Takeuchi and Shizuo Akira

    Nat Immunol, 7 (4), 427, 2006.

Link

http://www.biken.osaka-u.ac.jp/