Laboratory of Genomic Research on Pathogenic Bacteria

Department of Infectious Diseases Control;

Subjects:

1. Characterization of the mechanism(s) used by bacterial pathogens to infect host organisms by identifying infection-related changes in pathogen genome expression.
2. Analysis of the mechanism(s) that lead to the emergence of new infectious diseases.
3. Investigation of the life cycles of bacterial pathogens in their natural environments.
4. Development of new methods for the rapid identification of bacterial pathogens based on genome information.

Published Papers

1. Identification of proteins secreted via Vibrio parahaemolyticus type III secretion system 1.

   Takahiro Ono, Kwon-Sam Park, Mayumi Ueta, Tetsuya Iida and Takeshi Honda

   Infect Immun, 74 (2), 1032-1042, 2006.
2. Cortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the alpha-helical region is involved in the localization of cortactin to bacterial attachment sites.

   Vlademir V Cantarelli, Toshio Kodama, Niels Nijstad, Said Kamal Abolghait, Tetsuya Iida and Takeshi Honda

   Cell Microbiol, 8 (5), 769-780, 2006.
3. Two type IV pili of Vibrio parahaemolyticus play different roles in biofilm formation.

   Akiko Shime-Hattori, Tetsuya Iida, Michiko Arita, Kwon-Sam Park, Toshio Kodama and Takeshi Honda

   FEMS Microbiol Lett, 264 (1), 89-97, 2006.
4. VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.

   Rabindra N Bhattacharjee, Kwon-Sam Park, Yutaro Kumagai, Kazuhisa Okada, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi and Shizuo Akira

   J Biol Chem, 281 (48), 36897-36904, 2006.

Link

http://www.biken.osaka-u.ac.jp/