Subjects:
- The role of heparin-binding EGF-like growth factor in development.
- The mode of actions of membrane-anchored growth factors.
- Ectodomain shedding mechanism of EGF family growth factor.
- Physiological role of CD9 and the tetraspanin family proteins.
- Epigenetics in germ cells: During germ cell differentiation, epigenetic information undergoes drastically changes. We are analyzing the molecular basis of the DNA methylation, histone modification and histone to protamine transition in spermatogenesis.
- Transcriptional regulation of germ cell specific genes: During male germ cell development, each differentiation step requires the expression of a specific set of precisely regulated genes. Some of these genes are exclusively expressed in male germ cells. We are characterizing the unique molecular mechanisms of the preinitiation complex formation for transcription in germ cells.
- Molecular basis and biological significance of epigenetical changes during germ cell differentiation.
- Transcriptional regulation of germ cell specific genes.
Published Papers
Kyoko Kakumoto, Ken Sasai, Taiko Sukezane, Chitose Oneyama, Satoshi Ishimaru, Kana Shibutani, Hiroto Mizushima, Eisuke Mekada, Hidesaburo Hanafusa and Tsuyoshi Akagi
Proc Natl Acad Sci U S A,
103 (14),
5490-5495,
2006.
Shingo Miyamoto, Hiroshi Yagi, Fusanori Yotsumoto, Tatsuhiko Kawarabayashi and Eisuke Mekada
Cancer Sci,
97 (5),
341-347,
2006.
Ryo Iwamoto and Eisuke Mekada
Cell Struct Funct,
31 (1),
1-14,
2006.
Xiaobiao Wang, Hiroto Mizushima, Satoshi Adachi, Minako Ohishi, Ryo Iwamoto and Eisuke Mekada
Cell Struct Funct,
31 (1),
15-27,
2006.
Katsuya Kominami, Chiyo Takagi, Tomoko Kurata, Atsushi Kitayama, Masami Nozaki, Tatsuya Sawasaki, Keisuke Kuida, Yaeta Endo, Noboru Manabe, Naoto Ueno and Kazuhiro Sakamaki
Genes Cells,
11 (7),
701-717,
2006.
Link
http://www.biken.osaka-u.ac.jp/
Keyword(s):
References:[Table of Contents 2006]