Department of Bacterial Infections

Subjects:

1. Analysis of the bacterial colonization factors and their host receptors.
2. Molecular analysis of the protein toxins produced by various enteropathogens.
3. Analysis of the structure and function of the type III secretion system and the pathogenic mechanism of its effector.
4. Genome analysis of bacterial pathogens to understand pathogenic mechanisms.

Published Papers

1. Two type IV pili of Vibrio parahaemolyticus play different roles in biofilm formation.

   Akiko Shime-Hattori, Tetsuya Iida, Michiko Arita, Kwon-Sam Park, Toshio Kodama and Takeshi Honda

   FEMS Microbiol Lett, 264 (1), 89-97, 2006.
2. VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.

   Rabindra N Bhattacharjee, Kwon-Sam Park, Yutaro Kumagai, Kazuhisa Okada, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi and Shizuo Akira

   J Biol Chem, 281 (48), 36897-36904, 2006.
3. Pore formation of thermostable direct hemolysin secreted from Vibrio parahaemolyticus in lipid bilayers.

   Akira Takahashi, Chiyo Yamamoto, Toshio Kodama, Kanami Yamashita, Nagakatsu Harada, Masayuki Nakano, Takeshi Honda and Yutaka Nakaya

   Int J Toxicol, 25 (5), 409-418, 2006.
4. In Planta production of immunogenic poliovirus peptide using tobacco mosaic virus-based vector system.

   Kazuhito Fujiyama, Wanida Saejung, Itaru Yanagihara, Junko Nakado, Ryo Misaki, Takeshi Honda, Yuichiro Watanabe and Tatsuji Seki

   J Biosci Bioeng, 101 (5), 398-402, 2006.
5. Cortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the alpha-helical region is involved in the localization of cortactin to bacterial attachment sites.

   Vlademir V Cantarelli, Toshio Kodama, Niels Nijstad, Said Kamal Abolghait, Tetsuya Iida and Takeshi Honda

   Cell Microbiol, 8 (5), 769-780, 2006.
6. Identification of proteins secreted via Vibrio parahaemolyticus type III secretion system 1.

   Takahiro Ono, Kwon-Sam Park, Mayumi Ueta, Tetsuya Iida and Takeshi Honda

   Infect Immun, 74 (2), 1032-1042, 2006.

Link

http://www.biken.osaka-u.ac.jp/