Department of Immunoregulation

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiency, paroxysmal nocturnal hemoglobinuria.
3. Roles of GPI in protozoan parasites.

Published Papers

1. New mutant Chinese hamster ovary cell representing an unknown gene for attachment of glycosylphosphatidylinositol to proteins.

   Yeongjin Hong, Ji Young Kang, Youn Uck Kim, Dong-Jun Shin, Hyon E Choy, Yusuke Maeda and Taroh Kinoshita

   Biochem Biophys Res Commun, 335 (4), 1060-1069, 2005.
2. Diagnosis and management of paroxysmal nocturnal hemoglobinuria.

   Charles Parker, Mitsuhiro Omine, Stephen Richards, Jun-Ichi Nishimura, Monica Bessler, Russell Ware, Peter Hillmen, Lucio Luzzatto, Neal Young, Taroh Kinoshita, Wendell Rosse and Gerard Socie

   Blood, 106 (12), 3699-3709, 2005.
3. Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization.

   Gen Kondoh, Hiromasa Tojo, Yuka Nakatani, Nobuyasu Komazawa, Chie Murata, Kazuo Yamagata, Yusuke Maeda, Taroh Kinoshita, Masaru Okabe, Ryo Taguchi and Junji Takeda

   Nat Med, 11 (2), 160-166, 2005.
4. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.

   Hisashi Ashida, Yeongjin Hong, Yoshiko Murakami, Nobue Shishioh, Nakaba Sugimoto, Youn Uck Kim, Yusuke Maeda and Taroh Kinoshita

   Mol Biol Cell, 16 (3), 1439-1448, 2005.
5. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol.

   Nobue Shishioh, Yeongjin Hong, Kazuhito Ohishi, Hisashi Ashida, Yusuke Maeda and Taroh Kinoshita

   J Biol Chem, 280 (10), 9728-9734, 2005.
6. PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol.

   Ji Young Kang, Yeongjin Hong, Hisashi Ashida, Nobue Shishioh, Yoshiko Murakami, Yasu S Morita, Yusuke Maeda and Taroh Kinoshita

   J Biol Chem, 280 (10), 9489-9497, 2005.
7. Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei.

   B K Kubata, Kisaburo Nagamune, Nobutoshi Murakami, Patrick Merkel, Zakayi Kabututu, Samuel K Martin, Taba M Kalulu, Haq Mustakuk, Mitsuru Yoshida, Mayumi Ohnishi-Kameyama, Taroh Kinoshita, Michael Duszenko and Yoshihiro Urade

   Int J Parasitol, 35 (1), 91-103, 2005.

Link

http://www.biken.osaka-u.ac.jp/