Department of Host Defense

Subjects:

1. Physiological roles of Toll-like receptor (TLR) family and signaling pathways via TLRs.
2. Pathogen recognition mechanisms by innate immune system.

Published Papers

1. CpG-activated Thy1.2(+) dendritic cells protect against lethal Listeria monocytogenes infection.

   Ken J Ishii, Shuichi Ito, Tomohiko Tamura, Hiroaki Hemmi, Jacqueline Conover, Keiko Ozato, Shizuo Akira and Dennis M Klinman

   Eur J Immunol, 35 (8), 2397-2405, 2005.
2. Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice.

   T Ohkawara, H Takeda, J Nishihira, K Miyashita, M Nihiwaki, Y Ishiguro, K Takeda, S Akira, T Iwanaga, T Sugiyama and M Asaka

   Clin Exp Immunol, 141 (3), 412-421, 2005.
3. MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus.

   David S Weiss, Kiyoshi Takeda, Shizuo Akira, Arturo Zychlinsky and Edgardo Moreno

   Infect Immun, 73 (8), 5137-5143, 2005.
4. Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70.

   Hye-Seong Mun, Fumie Aosai, Kazumi Norose, Lian-Xun Piao, Hao Fang, Shizuo Akira and Akihiko Yano

   Infect Immun, 73 (8), 4634-4642, 2005.
5. Cell Type-Specific Involvement of RIG-I in Antiviral Response.

   Hiroki Kato, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Tohru Tsujimura, Kiyoshi Takeda, Takashi Fujita, Osamu Takeuchi and Shizuo Akira

   Immunity, 23 (1), 19-28, 2005.
6. Muramyl Dipeptide Enhances Osteoclast Formation Induced by Lipopolysaccharide, IL-1α, and TNF-α through Nucleotide-Binding Oligomerization Domain 2-Mediated Signaling in Osteoblasts.

   Shuhua Yang, Naoyuki Takahashi, Teruhito Yamashita, Nobuaki Sato, Masahiro Takahashi, Makio Mogi, Takashi Uematsu, Yasuhiro Kobayashi, Yuko Nakamichi, Kiyoshi Takeda, Shizuo Akira, Haruhiko Takada, Nobuyuki Udagawa and Kiyofumi Furusawa

   J Immunol, 175 (3), 1956-1964, 2005.
7. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.

   Sean R Christensen, Michael Kashgarian, Lena Alexopoulou, Richard A Flavell, Shizuo Akira and Mark J Shlomchik

   J Exp Med, 202 (2), 321-331, 2005.
8. Toll-like receptor 3 and STAT-1 contribute for dsRNA+IFN-gamma -induced apoptosis in primary pancreatic beta -cells.

   Joanne Rasschaert, Laurence Ladrière, Maryse Urbain, Zeynep Dogusan, Bitty Katabua, Shintaro Sato, Shizuo Akira, Conny Gysemans, Chantal Mathieu and Decio L Eizirik

   J Biol Chem, 280 (40), 33984-33991, 2005.
9. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.

   Wouter J de Jonge, Esmerij P van der Zanden, Frans O The, Maarten F Bijlsma, David J van Westerloo, Roelof J Bennink, Hans-Rudolf Berthoud, Satoshi Uematsu, Shizuo Akira, Rene M van den Wijngaard and Guy E Boeckxstaens

   Nat Immunol, 6 (8), 844-851, 2005.
10. Priming Effect of Lipopolysaccharide on Acetyl-Coenzyme A:Lyso-Platelet-Activating Factor Acetyltransferase Is MyD88 and TRIF Independent.

    Hideo Shindou, Satoshi Ishii, Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira and Takao Shimizu

    J Immunol, 175 (2), 1177-1183, 2005.
11. Microglia-specific expression of microsomal prostaglandin E synthase-1 contributes to lipopolysaccharide-induced prostaglandin E production.

    Yuri Ikeda-Matsuo, Yuji Ikegaya, Norio Matsuki, Satoshi Uematsu, Shizuo Akira and Yasuharu Sasaki

    J Neurochem, 94 (6), 1546-1558, 2005.
12. Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.

    Yuko Kato, Atsushi Iwama, Yuko Tadokoro, Kazuya Shimoda, Mayu Minoguchi, Shizuo Akira, Minoru Tanaka, Atsushi Miyajima, Toshio Kitamura and Hiromitsu Nakauchi

    J Exp Med, 202 (1), 169-179, 2005.
13. House dust extracts elicit Toll-like receptor-dependent dendritic cell responses.

    Jared Boasen, Dugald Chisholm, Lev Lebet, Shizuo Akira and Anthony A Horner

    J Allergy Clin Immunol, 116 (1), 185-191, 2005.
14. TLR signalling and the function of dendritic cells.

    Hiroaki Hemmi and Shizuo Akira

    Chem Immunol Allergy, 86, 120-135, 2005.
15. CXCL13 is an arrest chemokine for B cells in high endothelial venules.

    Naotoshi Kanemitsu, Yukihiko Ebisuno, Toshiyuki Tanaka, Kazuhiro Otani, Haruko Hayasaka, Tsuneyasu Kaisho, Shizuo Akira, Koko Katagiri, Tatsuo Kinashi, Naoya Fujita, Takashi Tsuruo and Masayuki Miyasaka

    Blood, 106 (8), 2613-2618, 2005.
16. Pathogen recognition with Toll-like receptors.

    Taro Kawai and Shizuo Akira

    Curr Opin Immunol, 17 (4), 338-344, 2005.
17. B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88.

    Rongcun Yang, Francisco Martinez Murillo, Michael J Delannoy, R Lee Blosser, William H Yutzy, Satoshi Uematsu, Kiyoshi Takeda, Shizuo Akira, Raphael P Viscidi and Richard B S Roden

    J Immunol, 174 (12), 7912-7919, 2005.
18. Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.

    Junji Uehori, Koichi Fukase, Takashi Akazawa, Satoshi Uematsu, Shizuo Akira, Kenji Funami, Masashi Shingai, Misako Matsumoto, Ichiro Azuma, Kumao Toyoshima, Shoichi Kusumoto and Tsukasa Seya

    J Immunol, 174 (11), 7096-7103, 2005.
19. The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.

    Yoshinori Nagai, Toshihiko Kobayashi, Yuji Motoi, Kohtaroh Ishiguro, Sachiko Akashi, Shin-ichiroh Saitoh, Yutaka Kusumoto, Tsuneyasu Kaisho, Shizuo Akira, Mitsuru Matsumoto, Kiyoshi Takatsu and Kensuke Miyake

    J Immunol, 174 (11), 7043-7049, 2005.
20. Role of TLR in B cell development: signaling through TLR4 promotes B cell maturation and is inhibited by TLR2.

    Elize A Hayashi, Shizuo Akira and Alberto Nobrega

    J Immunol, 174 (11), 6639-6647, 2005.
21. Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer.

    Rongcun Yang, Cosette M Wheeler, Xiaojiang Chen, Satoshi Uematsu, Kiyoshi Takeda, Shizuo Akira, Diana V Pastrana, Raphael P Viscidi and Richard B S Roden

    J Virol, 79 (11), 6741-6750, 2005.
22. IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment.

    A Richard Kitching, Amanda L Turner, Gabrielle R A Wilson, Timothy Semple, Dragana Odobasic, Jennifer R Timoshanko, Kim M O'Sullivan, Peter G Tipping, Kiyoshi Takeda, Shizuo Akira and Stephen R Holdsworth

    J Am Soc Nephrol, 16 (7), 2023-2033, 2005.
23. Role of lipoteichoic acid in the phagocyte response to group B streptococcus.

    Philipp Henneke, Siegfried Morath, Satoshi Uematsu, Stefan Weichert, Markus Pfitzenmaier, Osamu Takeuchi, Andrea Müller, Claire Poyart, Shizuo Akira, Reinhard Berner, Giuseppe Teti, Armin Geyer, Thomas Hartung, Patrick Trieu-Cuot, Dennis L Kasper and Douglas T Golenbock

    J Immunol, 174 (10), 6449-6455, 2005.
24. Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1.

    Daniel S Mansur, Erna G Kroon, Maurício L Nogueira, Rosa M E Arantes, Soraia C O Rodrigues, Shizuo Akira, Ricardo T Gazzinelli and Marco A Campos

    Am J Pathol, 166 (5), 1419-1426, 2005.
25. TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.

    Satoshi Kishida, Hideki Sanjo, Shizuo Akira, Kunihiro Matsumoto and Jun Ninomiya-Tsuji

    Genes Cells, 10 (5), 447-454, 2005.
26. Regulation of Id2 expression by CCAAT/enhancer binding protein beta.

    Kazuhiro Karaya, Seiichi Mori, Hisashi Kimoto, Yoko Shima, Yoshihito Tsuji, Hisanori Kurooka, Shizuo Akira and Yoshifumi Yokota

    Nucleic Acids Res, 33 (6), 1924-1934, 2005.
27. Down-regulation of dopamine transporter and abnormal behavior in STAT6-deficient mice.

    Kazunori Yukawa, Hiroyuki Iso, Tetsuji Tanaka, Yuji Tsubota, Kyoko Owada-Makabe, Tao Bai, Kiyoshi Takeda, Shizuo Akira and Masanobu Maeda

    Int J Mol Med, 15 (5), 819-825, 2005.
28. Immunoregulation in Urinary Tract Inflammation--A Role of Tamm-Horsfall Glycoprotein: Tamm-Horsfall Glycoprotein Links Innate Immune Cell Activation with Adaptive Immunity via a Toll-Like Receptor-4-Dependent Mechanism. J Clin Invest 115: 468-475, 2005.

    Md Säemann, T Weichhart, M Zeyda, G Staffler, M Schunn, Km Stuhlmeier, Y Sobanov, Tm Stulnig, S Akira, A von Gabain, U von Ahsen, Wh Horl, Gj Zlabinger, T Tanaka, T Miyata, R Inagi, T Fujita, M Nangaku, M Desvarieux, Rt Demmer, T Rundek, B Boden-Albala, Dr Jacobs, Rl Sacco and Pn Papapanou

    J Am Soc Nephrol, 16 (4), 829-836, 2005.
29. Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling.

    Yasuyuki Asai, Masahito Hashimoto, Hansel M Fletcher, Kensuke Miyake, Shizuo Akira and Tomohiko Ogawa

    Infect Immun, 73 (4), 2157-2163, 2005.
30. A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.

    Hiroyuki Yoshitomi, Noriko Sakaguchi, Katsuya Kobayashi, Gordon D Brown, Tomoyuki Tagami, Toshiko Sakihama, Keiji Hirota, Satoshi Tanaka, Takashi Nomura, Ichiro Miki, Siamon Gordon, Shizuo Akira, Takashi Nakamura and Shimon Sakaguchi

    J Exp Med, 201 (6), 949-960, 2005.
31. Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.

    Atsushi Kumanogoh, Takashi Shikina, Kazuhiro Suzuki, Satoshi Uematsu, Kazunori Yukawa, Shin-Ichiro Kashiwamura, Hiroko Tsutsui, Midori Yamamoto, Hyota Takamatsu, Elizabeth P Ko-Mitamura, Noriko Takegahara, Satoko Marukawa, Isao Ishida, Hiroshi Morishita, Durbaka V R Prasad, Manabu Tamura, Masayuki Mizui, Toshihiko Toyofuku, Shizuo Akira, Kiyoshi Takeda, Masaru Okabe and Hitoshi Kikutani

    Immunity, 22 (3), 305-316, 2005.
32. Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium.

    Samithamby Jeyaseelan, Rizwan Manzer, Scott K Young, Masahiro Yamamoto, Shizuo Akira, Robert J Mason and G Scott Worthen

    Am J Respir Cell Mol Biol, 32 (6), 531-539, 2005.
33. Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.

    Christoph Kalis, Marina Gumenscheimer, Nikolaus Freudenberg, Sandrine Tchaptchet, György Fejer, Antje Heit, Shizuo Akira, Chris Galanos and Marina A Freudenberg

    J Immunol, 174 (7), 4295-4300, 2005.
34. Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.

    Adrien Breiman, Nathalie Grandvaux, Rongtuan Lin, Catherine Ottone, Shizuo Akira, Mitsutoshi Yoneyama, Takashi Fujita, John Hiscott and Eliane F Meurs

    J Virol, 79 (7), 3969-3978, 2005.
35. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction.

    Satoshi Uematsu, Shintaro Sato, Masahiro Yamamoto, Tomonori Hirotani, Hiroki Kato, Fumihiko Takeshita, Michiyuki Matsuda, Cevayir Coban, Ken J Ishii, Taro Kawai, Osamu Takeuchi and Shizuo Akira

    J Exp Med, 201 (6), 915-923, 2005.
36. PI3K integrates the action of insulin and leptin on hypothalamic neurons.

    Allison Wanting Xu, Christopher B Kaelin, Kiyoshi Takeda, Shizuo Akira, Michael W Schwartz and Gregory S Barsh

    J Clin Invest, 115 (4), 951-958, 2005.
37. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria.

    Tomonori Hirotani, Pui Y Lee, Hirotaka Kuwata, Masahiro Yamamoto, Makoto Matsumoto, Ichiro Kawase, Shizuo Akira and Kiyoshi Takeda

    J Immunol, 174 (6), 3650-3657, 2005.
38. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity.

    Gowdahalli Krishnegowda, Adeline M Hajjar, Jianzhong Zhu, Erika J Douglass, Satoshi Uematsu, Shizuo Akira, Amina S Woods and D Channe Gowda

    J Biol Chem, 280 (9), 8606-8616, 2005.
39. Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus.

    Loïc Guillot, Ronan Le Goffic, Sarah Bloch, Nicolas Escriou, Shizuo Akira, Michel Chignard and Mustapha Si-Tahar

    J Biol Chem, 280 (7), 5571-5580, 2005.
40. Toll-like receptor 6-independent signaling by diacylated lipopeptides.

    Ute Buwitt-Beckmann, Holger Heine, Karl-Heinz Wiesmüller, Günther Jung, Roland Brock, Shizuo Akira and Artur J Ulmer

    Eur J Immunol, 35 (1), 282-289, 2005.
41. The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy.

    Kazunori Yukawa, Masanori Kishino, Katsuaki Hoshino, Nobuyuki Shirasawa, Akihiko Kimura, Yuji Tsubota, Kyoko Owada-Makabe, Tao Bai, Tetsuji Tanaka, Takashi Ueyama, Masakazu Ichinose, Kiyoshi Takeda, Shizuo Akira and Masanobu Maeda

    Int J Mol Med, 15 (1), 73-78, 2005.
42. Toll-like receptors in innate immunity.

    Kiyoshi Takeda and Shizuo Akira

    Int Immunol, 17 (1), 1-14, 2005.
43. Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus.

    Koenraad F Van Der Sluijs, Leontine J R Van Elden, Ramon Arens, Monique Nijhuis, Rob Schuurman, Sandrine Florquin, Joan Kwakkel, Shizuo Akira, Henk M Jansen, René Lutter and Tom Van Der Polls

    Immunology, 114 (1), 112-120, 2005.
44. Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila.

    Morikazu Akamine, Futoshi Higa, Noriko Arakaki, Kazuyoshi Kawakami, Kiyoshi Takeda, Shizuo Akira and Atsushi Saito

    Infect Immun, 73 (1), 352-361, 2005.
45. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.

    Cevayir Coban, Ken J Ishii, Taro Kawai, Hiroaki Hemmi, Shintaro Sato, Satoshi Uematsu, Masahiro Yamamoto, Osamu Takeuchi, Sawako Itagaki, Nirbhay Kumar, Toshihiro Horii and Shizuo Akira

    J Exp Med, 201 (1), 19-25, 2005.
46. Toll-like receptor downstream signaling.

    Taro Kawai and Shizuo Akira

    Arthritis Res Ther, 7 (1), 12-19, 2005.
47. STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy.

    Kazunori Yukawa, Masanori Kishino, Mikako Goda, Xiang-Ming Liang, Akihiko Kimura, Tetsuji Tanaka, Tao Bai, Kyoko Owada-Makabe, Yuji Tsubota, Takashi Ueyama, Masakazu Ichinose, Masanobu Maeda, Kiyoshi Takeda and Shizuo Akira

    Int J Mol Med, 15 (2), 225-230, 2005.
48. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism.

    Marcus D Säemann, Thomas Weichhart, Maximilian Zeyda, Günther Staffler, Michael Schunn, Karl M Stuhlmeier, Yuri Sobanov, Thomas M Stulnig, Shizuo Akira, Alexander von Gabain, Uwe von Ahsen, Walter H Hörl and Gerhard J Zlabinger

    J Clin Invest, 115 (2), 468-475, 2005.
49. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.

    Karl S Lang, Mike Recher, Tobias Junt, Alexander A Navarini, Nicola L Harris, Stefan Freigang, Bernhard Odermatt, Curdin Conrad, Lars M Ittner, Stefan Bauer, Sanjiv A Luther, Satoshi Uematsu, Shizuo Akira, Hans Hengartner and Rolf M Zinkernagel

    Nat Med, 11 (2), 138-145, 2005.
50. Direct injection of plasmid DNA into the skin induces dermatitis by activation of monocytes through toll-like receptor 9.

    D Sawamura, R Abe, M Goto, M Akiyama, H Hemmi, S Akira and H Shimizu

    J Gene Med, 7 (5), 664-671, 2005.
51. A20 is a negative regulator of IFN regulatory factor 3 signaling.

    Tatsuya Saitoh, Masahiro Yamamoto, Makoto Miyagishi, Kazunari Taira, Makoto Nakanishi, Takashi Fujita, Shizuo Akira, Naoki Yamamoto and Shoji Yamaoka

    J Immunol, 174 (3), 1507-1512, 2005.
52. The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms.

    Siegfried Hapfelmeier, Bärbel Stecher, Manja Barthel, Marcus Kremer, Andreas J Müller, Mathias Heikenwalder, Thomas Stallmach, Michael Hensel, Klaus Pfeffer, Shizuo Akira and Wolf-Dietrich Hardt

    J Immunol, 174 (3), 1675-1685, 2005.
53. Roles of Stat3 and ERK in G-CSF Signaling.

    Kenjirou Kamezaki, Kazuya Shimoda, Akihiko Numata, Takashi Haro, Haruko Kakumitsu, Masumi Yoshie, Masahiro Yamamoto, Kiyoshi Takeda, Tadashi Matsuda, Shizuo Akira, Katsuhiro Ogawa and Mine Harada

    Stem Cells, 23 (2), 252-263, 2005.
54. Spontaneous Ocular Surface Inflammation and Goblet Cell Disappearance in IκBζ Gene-Disrupted Mice.

    Mayumi Ueta, Junji Hamuro, Masahiro Yamamoto, Kazuhiro Kaseda, Shizuo Akira and Shigeru Kinoshita

    Invest Ophthalmol Vis Sci, 46 (2), 579-588, 2005.
55. MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.

    Akihiro Araki, Takanori Kanai, Takahiro Ishikura, Shin Makita, Koji Uraushihara, Ryoichi Iiyama, Teruji Totsuka, Kiyoshi Takeda, Shizuo Akira and Mamoru Watanabe

    J Gastroenterol, 40 (1), 16-23, 2005.
56. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.

    Tomonori Hirotani, Masahiro Yamamoto, Yutaro Kumagai, Satoshi Uematsu, Ichiro Kawase, Osamu Takeuchi and Shizuo Akira

    Biochem Biophys Res Commun, 328 (2), 383-392, 2005.
57. A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages.

    Toshihiko Suzuki, Kenji Nakanishi, Hiroko Tsutsui, Hiroki Iwai, Shizuo Akira, Naohiro Inohara, Mathias Chamaillard, Gabriel Nuñez and Chihiro Sasakawa

    J Biol Chem, 280 (14), 14042-14050, 2005.
58. CpG RNA: Identification of Novel Single-Stranded RNA That Stimulates Human CD14+CD11c+ Monocytes.

    Takahiro Sugiyama, Mayda Gursel, Fumihiko Takeshita, Cevayir Coban, Jacqueline Conover, Tsuneyasu Kaisho, Shizuo Akira, Dennis M Klinman and Ken J Ishii

    J Immunol, 174 (4), 2273-2279, 2005.
59. Involvement of the toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus.

    Takayuki Abe, Hiroaki Hemmi, Hironobu Miyamoto, Kohji Moriishi, Shinichi Tamura, Hiroshi Takaku, Shizuo Akira and Yoshiharu Matsuura

    J Virol, 79 (5), 2847-2858, 2005.
60. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.

    Veit Hornung, Margit Guenthner-Biller, Carole Bourquin, Andrea Ablasser, Martin Schlee, Satoshi Uematsu, Anne Noronha, Muthiah Manoharan, Shizuo Akira, Antonin de Fougerolles, Stefan Endres and Gunther Hartmann

    Nat Med, 11 (3), 263-270, 2005.
61. Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration.

    Ekihiro Seki, Hiroko Tsutsui, Yuji Iimuro, Tetsuji Naka, Gakuhei Son, Shizuo Akira, Tadamitsu Kishimoto, Kenji Nakanishi and Jiro Fujimoto

    Hepatology, 41 (3), 443-450, 2005.

Link

http://www.biken.osaka-u.ac.jp/