Department of Immunoregulation

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiency, paroxysmal nocturnal hemoglobinuria.
3. Roles of GPI in protozoan parasites.

Published Papers

1. Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p.

   Satoshi Tanaka, Yusuke Maeda, Yuko Tashima and Taroh Kinoshita

   J Biol Chem, 279 (14), 14256-14263, 2004.
2. Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors.

   Kisaburo Nagamune, Alvaro Acosta-Serrano, Haruki Uemura, Reto Brun, Christina Kunz-Renggli, Yusuke Maeda, Michael A J Ferguson and Taroh Kinoshita

   J Exp Med, 199 (10), 1445-1450, 2004.
3. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan.

   Jun-Ichi Nishimura, Yuzuru Kanakura, Russell E Ware, Tsutomu Shichishima, Hideki Nakakuma, Haruhiko Ninomiya, Carlos M Decastro, Sharon Hall, Akihisa Kanamaru, Keith M Sullivan, Hideaki Mizoguchi, Mitsuhiro Omine, Taroh Kinoshita and Wendell F Rosse

   Medicine (Baltimore), 83 (3), 193-207, 2004.
4. GPI-anchor deficiency in myeloid cells causes impaired FcgammaR effector functions.

   Wouter L W Hazenbos, Björn E Clausen, Junji Takeda and Taroh Kinoshita

   Blood, 104 (9), 2825-2831, 2004.
5. Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene.

   Kosuke Yusa, Kyoji Horie, Gen Kondoh, Michiyoshi Kouno, Yusuke Maeda, Taroh Kinoshita and Junji Takeda

   Nature, 429 (6994), 896-899, 2004.
6. Enhanced responses of glycosylphosphatidylinositol anchor-deficient T lymphocytes.

   Wouter L W Hazenbos, Yoshiko Murakami, Jun-Ichi Nishimura, Junji Takeda and Taroh Kinoshita

   J Immunol, 173 (6), 3810-3815, 2004.

Link

http://www.biken.osaka-u.ac.jp/