Department of Molecular Cell Biology

Subjects:

1. Molecular analysis of stem cell systems.
2. Differentiation of hematopoietic cell system.
3. Development of germ cell system.

Papers published in 2003

1. Mouse germ cell-less as an essential component for nuclear integrity.

   Tohru Kimura, Chizuru Ito, Shoko Watanabe, Tohru Takahashi, Masahito Ikawa, Kentaro Yomogida, Yukiko Fujita, Megumi Ikeuchi, Noriko Asada, Kiyomi Matsumiya, Akihiko Okuyama, Masaru Okabe, Kiyotaka Toshimori and Toru Nakano

   Mol Cell Biol, 23 (4), 1304-1315, 2003.
2. Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.

   Akira Suzuki, Satoshi Itami, Minako Ohishi, Koichi Hamada, Tae Inoue, Nobuyasu Komazawa, Haruki Senoo, Takehiko Sasaki, Junji Takeda, Motomu Manabe, Tak Wah Mak and Toru Nakano

   Cancer Res, 63 (3), 674-681, 2003.
3. Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

   Akira Suzuki, Tsuneyasu Kaisho, Minako Ohishi, Manae Tsukio-Yamaguchi, Takeshi Tsubata, Pandelakis A Koni, Takehiko Sasaki, Tak Wah Mak and Toru Nakano

   J Exp Med, 197 (5), 657-667, 2003.
4. Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production.

   Tohru Kimura, Akira Suzuki, Yukiko Fujita, Kentaro Yomogida, Hilda Lomeli, Noriko Asada, Megumi Ikeuchi, Andras Nagy, Tak W Mak and Toru Nakano

   Development, 130 (8), 1691-1700, 2003.
5. Differences between peripheral blood and cord blood in the kinetics of lineage-restricted hematopoietic cells: implications for delayed platelet recovery following cord blood transplantation.

   Kazuta Yasui, Kayoko Matsumoto, Fumiya Hirayama, Yoshihiko Tani and Toru Nakano

   Stem Cells, 21 (2), 143-151, 2003.
6. Physiological functions of Pten in mouse tissues.

   Hiroyuki Kishimoto, Koichi Hamada, Mary Saunders, Stephanie Backman, Takehiko Sasaki, Toru Nakano, Tak Wah Mak and Akira Suzuki

   Cell Struct Funct, 28 (1), 11-21, 2003.
7. A stromal cell-derived membrane protein that supports hematopoietic stem cells.

   Hiroo Ueno, Mao Sakita-Ishikawa, Yoshihiro Morikawa, Toru Nakano, Toshio Kitamura and Masaki Saito

   Nat Immunol, 4 (5), 457-463, 2003.
8. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.

   Masaaki Masuhara, Kenji Nagao, Mitsuo Nishikawa, Tohru Kimura and Toru Nakano

   Biochem Biophys Res Commun, 308 (4), 927-932, 2003.
9. Hematopoietic stem cells: generation and manipulation.

   Toru Nakano

   Trends Immunol, 24 (11), 589-594, 2003.
10. Cadherin-mediated cell interaction regulates germ cell determination in mice.

    Daiji Okamura, Thoru Kimura, Toru Nakano and Yasuhisa Matsui

    Development, 130 (26), 6423-6430, 2003.
11. Stella is a maternal effect gene required for normal early development in mice.

    Bernhard Payer, Mitinori Saitou, Sheila C Barton, Rosemary Thresher, John P C Dixon, Dirk Zahn, William H Colledge, Mark B L Carlton, Toru Nakano and M Azim Surani

    Curr Biol, 13 (23), 2110-2117, 2003.
12. In vitro differentiation of mouse embryonic stem cells to hematopoietic cells on an OP9 stromal cell monolayer.

    Kenji Kitajima, Makoto Tanaka, Jie Zheng, Eiko Sakai-Ogawa and Toru Nakano

    Methods Enzymol, 365, 72-83, 2003.
13. Development and analysis of megakaryocytes from murine embryonic stem cells.

    Koji Eto, Andrew L Leavitt, Toru Nakano and Sanford J Shattil

    Methods Enzymol, 365, 142-158, 2003.

Link

http://www.biken.osaka-u.ac.jp/