Department of Cell Biology

Subjects:

1. The role of heparin-binding EGF-like growth factor in development.
2. The mode of actions of membrane-anchored growth factors.
3. Ectodomain shedding mechanism of EGF family growth factor.
4. Physiological role of CD9 and the tetraspanin family proteins.

Papers published in 2003

1. The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling cascades.

   Hisanori Takenobu, Ayano Yamazaki, Michinari Hirata, Toshiyuki Umata and Eisuke Mekada

   J Biol Chem, 278 (19), 17255-17262, 2003.
2. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.

   Ryo Iwamoto, Satoru Yamazaki, Masanori Asakura, Seiji Takashima, Hidetoshi Hasuwa, Kenji Miyado, Satoshi Adachi, Masafumi Kitakaze, Koji Hashimoto, Gerhard Raab, Daisuke Nanba, Shigeki Higashiyama, Masatsugu Hori, Michael Klagsbrun and Eisuke Mekada

   Proc Natl Acad Sci U S A, 100 (6), 3221-3226, 2003.
3. Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.

   Yoshito Takeda, Isao Tachibana, Kenji Miyado, Masatoshi Kobayashi, Toru Miyazaki, Toshiki Funakoshi, Hiromi Kimura, Hiroyuki Yamane, Yoshiyuki Saito, Hiroyuki Goto, Tsutomu Yoneda, Mitsuhiro Yoshida, Toru Kumagai, Tadashi Osaki, Seiji Hayashi, Ichiro Kawase and Eisuke Mekada

   J Cell Biol, 161 (5), 945-956, 2003.
4. Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.

   Satoru Yamazaki, Ryo Iwamoto, Kazuko Saeki, Masanori Asakura, Seiji Takashima, Ayano Yamazaki, Rina Kimura, Hiroto Mizushima, Hiroki Moribe, Shigeki Higashiyama, Masayuki Endoh, Yasufumi Kaneda, Satoshi Takagi, Satoshi Itami, Naoki Takeda, Gen Yamada and Eisuke Mekada

   J Cell Biol, 163 (3), 469-475, 2003.

Link

http://www.biken.osaka-u.ac.jp/