小林班「ゲノムの死と再生：DNA二重鎖切断とその帰結のバイオロジー」
研究代表者；小林一三
分担者；板谷光泰

小林　一三
K. Kusano, Y. Asami, A. Fujita, M. Tanokura, I. Kobayashi. (2003)
Type I restriction enzyme with RecA protein promotes illegitimate recombination.
Plasmid (in press)

I. Kobayashi. (2003)
Restriction-modification systems as minimal forms of life. In Restriction endonucleases. A. Pingoud (ed.) (Springer Verlag, Berlin)　(in press)

I. Kobayashi. (2003)
Genetic addiction --- a principle in gene symbiosis in a genome. In The Biology of Plasmids. B. Funnell and G. Phillips Ed. (ASM Press)　(in press)

I. Kobayashi. (2003)
Addiction as a principle of symbiosis of genetic elements in the genome --- restriction enzymes and mitochondria. In Symbiosis and Cellular Organelles. M. Sugiura, Ed. (International Society of Endocytobiology, Germany)( in press)

N. Handa, I. Kobayashi. (2003)
Accumulation of large non-circular forms of the chromosome in recombination-defective mutants of Escherichia coli.
BMC Molecular Biology, 4: 5.

M. Sadykov, Y. Asami, H. Niki, N. Handa, M. Itaya, M. Tanokura, I. Kobayashi (2003)
Multiplication of a restriction modification gene complex.
Mol. Microbiol., 48: 417-427.

I. Kobayashi. (2003)
Life cycle of restriction-modification systems, powers in genome evolution. In Genome Science --- Towards a new paradigm? H. Yoshikawa, N. Ogasawara, N. Satoh, Eds. (Elsevier Science, Amsterdam), pp. 191-202.

Y. Katayama, F. Takeuchi, T. Ito, X.X. Ma, Y. Mizutani-Ui, I. Kobayashi, K. Hiramatsu (2003)
Identification in a Methicillin-Susceptible Staphylococcus hominis of an Active Primordial Mobile Genetic Element for the Staphylococcal Cassette Chromosome mec (SCCmec) which ﾐ in Methicillin-Resistant Staphylococcus aureus ﾐ is the Carrier of the Resistance Gene mec.
J. Bacteriol., 185: 2711-2722.

Y. Fujitani, I. Kobayashi (2003)
Asymmetric Random Walk in a Reaction Intermediate of Homologous Recombination.
J. Theor. Biol., 220: 359-370.

R.J. Roberts, M. Belfort, T. Bestor, A. S. Bhagwat, T. A. Bickle, J. Bitinaite, R. M. Blumenthal, S. K. Degtyarev, D. T.F. Dryden, K. Dybvig, K. Firman, E. S. Gromova, R. I. Gumport, S. E. Halford, S. Hattman, J. Heitman, D. P. Hornby, A. Janulaitis, A. Jeltsch, J. Josephsen, A. Kiss, T. R. Klaenhammer, I. Kobayashi, H. Kong, D. H. Kruger, S. Lacks, M. G. Marinus, M. Miyahara, R. D. Morgan, N. E. Murray, V. Nagaraja, A. Piekarowicz, A. Pingoud, E. Raleigh, D. N. Rao, N. Reich, V. E. Repin, E. U. Selker, P. Shaw, D. C. Stein, B. L. Stoddard, W. Szybalski, T. A. Trautner, J. L. Van Etten, J. M.B. Vitor, G. G. Wilson, S. Xu.(2003)
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
Nucleic Acids Res., 31: 1805-1812.

N. Takahashi, H. Yoshikura, I. Kobayashi (2003)
An Escherichia coli strain, BJ5183, that shows highly efficient conservative (two-progeny) DNA double-strand break repair of restriction breaks.
Gene, 303: 89-97.

N. Takahashi, Y. Naito, N. Handa, I. Kobayashi (2002)
A DNA methyltransferase can protect the genome from post-disturbance attack by a restriction-modification gene complex.
J. Bacteriol., 184: 6100-6108.

Y. Fujitani, S. Mori, I. Kobayashi (2002)
A reaction-diffusion model for interference in meiotic crossing-over.
Genetics, 161: 365-372.

I. Kobayashi (2002)
DNA double-strand break repair in bacteria.　In the Encyclopedia of Life Sciences, (Nature Publishing Group, Macmillan Reference Limited, London), (on-line publication) No. 576.

K. Nakao, A. Chinen, A. Nobusato, Y. Fujitani, I. Uchiyama, I. Kobayashi (2001)
Relation between restriction modification genes and genome rearrangements suggested from genome sequence comparison within Genus Neisseria. In Genome Informatics 2001. H. Matsuda, L. Wong, S. Miyano, T. Takagi, Eds. (Universal Academy Press, Tokyo, Japan), pp. 398-399.

I. Kobayashi (2001)
Behavior of restriction-modification systems as selfish mobile elements and their impact on genome evolution.
Nucleic Acids Research, 29, 3742-3756.

Kuroda, M., Ohta, T., Uchiyama, I., Baba, T., Yuzawa, H., Kobayashi, I., Cui, L., Oguchi, A., Aoki, K., Nagai, Y., Lian, J., Ito, T., Kanamori, M., Matsumaru, H., Maruyama, A., Murakami, H., Hosoyama, A., Mizutani-Ui, Y., Takahashi, N. K., Sawano, T., Inoue, R., Kaito, C., Sekimizu, K., Hirakawa, H., Kuhara, S., Goto, S., Yabuzaki, J., Kanehisa, M., Yamashita, A., Oshima, K., Furuya, K., Yoshino, C., Shiba, T., Hattori, M., Ogasawara, N., Hayashi, H., Hiramatsu, K.(2001)
Whole genome sequencing of meticillin-resistant Staphylococcus aureus.
The Lancet, 357, 1225-1240.

N. Handa, Y. Nakayama, M. Sadykov and I. Kobayashi (2001)
Experimental genome evolution: large-scale genome rearrangements associated with resistance to replacement of a chromosomal restriction-modification gene complex.
Mol. Microbiol. 40, 932-940.

小林一三 (2003)
制限酵素修飾酵素遺伝子の自己増殖の発見。海洋、号外33号、128-136.

小林一三 (2002)
メイナードスミス博士京都賞受賞記念ワークショップ講演：ゲームの場としてのゲノム --- あるいは、遺伝子はなぜ愛し合うのか？　遺伝、56, 70-76.

小林一三　(2001)
ゲノム比較：ゲノムを造り替えていた制限酵素修飾酵素遺伝子. 蛋白質核酸酵素、臨時増刊号「ゲノムサイエンスの新たなる挑戦」46：2393-2399.

板谷　光泰　

Itaya, M., S. Shaheduzzaman, K. Matsui, A. Omori, and T. Tsuji (2001)
Green marker for Bacillus subtilis colonies.
Biosci. Biotech Biochem. 65, 579-583.

Ｔsuge K, Itaya M. (2001)
Recombinational transfer of 100-kb genomic DNA to plasmid in Bacillus subtilis 168.
J Bacteriol. 2001 183 5453-5456.

Sadykov , M., Y. Asami, H. Niki, M. Itaya, M. Tanokura, and I. Kobayashi (2003)
Amplification of selfish restriction modification genes.
Mol Microbiol, 48 417 -425.

Kaneko, S., K. Tsuge, T. Takeuchi, and M. Itaya (2003)
Conversion of Submegasized DNA to Desired Structures Using A Novel Bacillus subtilis Genome Vector.
Nucleic Acids Res. (in press)

Itaya, M., K. Fujita, M. Koizumi, T. Ikeuchi, and K. Tsuge (2003)
Stable Positional Cloning of Long Continuous DNA in the Bacillus subtilis genome vector.
J. Biochem. (in press)

Sato, A., Kanai, A. M. Itaya, and M. Tomita (2003)
Cooperative regulation for Okazaki fragment processing by RNase HII and FEN-1 purified from a hyperthermophilic archaeon, Pyrococcus furiosus.
BBRC (in press)

板谷光泰 (2000)
「ゲノム工学〜微生物の新たな時代を切り開く先端技術」タイテックマガジン、Vol.02.

板谷光泰 (2000)
「ゲノムをデザインする」、 岩波科学、vol.70, No.12, 1073-1080.

板谷光泰 (2002)
「巨大ＤＮＡ操作法：枯草菌ゲノムベクターへのメガクローニング」、化学と生物、vol. 40, No.5, 306-308.

back