発表論文

□発表論文

2022

[160] Kajiwara K, Chen PK, Abe Y, Okuda S, Kon S, Adachi J, Tomonaga T, Fujita M and Okada M (2022).
Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition.
Current Biology, in press

[159] Tamura T, Torii S, Kajiwara K, Anzai I, Fujioka Y, Noda K, Taguwa S, Morioka Y, Suzuki R, Fauzyah Y, Ono C, Ohba Y, Okada M, Fukuhara T and Matsuura Y. (2022).
Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses.
PLoS Pathogens, 18, e1010593

[158] Kimura T, Hayama Y, Okuzaki D, Nada S and Okada M (2022).
The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EB.
J Biol Chem, 293, 101744

[157] Kawase N, Sugihara A, Kajiwara K, Hiroshima M, Akamatsu K, Nada S, Matsumoto K, Ueda M and Okada M (2022).
SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
J Biol Chem, 293, 101630

2021

[156] Hesaka A, Tsukamoto Y, Nada S, Kawamura M, Ichimaru N, Sakai S, Nakane S, Mita M, Okuzaki D, Okada M, Isaka Y and Kimura T (2021).
D-Serine mediates cellular proliferation for kidney remodeling.
Kidney360, 2, 1611-1624

[155] Liu Y, Soh W, Kishikawa J, Hirose M, Nakayama E, Li S, Sasai M,Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley D, Shioda T and Arase H (2021).
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
Cell, 184, 3452-3466

[154] Nakatani T, Tsujimoto K, Park J, Jo T, Kimura T, Hayama Y, Konaka H, Morita T, Kato Y, Nishide S, Koyama S, Nada S, Okada M, Takamatsu H and Kumanogoh A (2021).
The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II.
Nature Communications, 12, 3333

[153] Chee W, Kurahashi Y, Kim J, Miura K, Okuzaki D, Ishitani T, Kajiwara K, Nada S, Okano H and Okada M (2021).
β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells.
Commun Biol, 4, 357

[152] Kajiwara K, Yamano S, Aoki K, Okuzaki D, Matsumoto K and Okada M. (2021).
CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.
Life Sci Alliance, 4, e202000832

2020

[151] Yao Y, Hong S, Ikeda T, Mori H, MacDougald OA, Nada S, Okada M and Inoki K. (2020).
Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity.
Mol Cell, 80, 437-451

[150] Nada S and Okada M. (2020).
Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1.
J Biochem, 168, 621-632

[149] Ito S, Nada S, Yamazaki D, Kimura T, Kajiwara K, Miki H and Okada M. (2020).
p18/Lamtor1-mTORC1 signaling controls development of mucin-producing goblet cells in the intestine.
Cell Structure and Function, 45, 93-105

[148] Kim J, Chee W, Yabuta N, Kajiwara K, Nada S and Okada M. (2020).
Atg5-mediated autophagy controls apoptosis/anoikis via p53/Rb pathway in naked mole-rat fibroblasts.
Biochem Biophys Res Commun, 528, 146-153

[147] Tanaka K, Ito Y, Kajiwara K, Nada S and Okada M. (2020).
Ubiquitination of Src promotes its secretion via small extracellular vesicles.
Biochem Biophys Res Commun, 525, 184-191

2019

[146] Tsukamoto T, Kajiwara K, Nada S and Okada M. (2019).
Src mediates TGF-β-induced intraocular pressure elevation in glaucoma.
J Cell Physiol, 234, 1730-1744

2018

[145] Kimura T, Kumanogoh A and Okada M. (2018).
Roles of Lamtor1 in Macrophages, CD4+ T-cells, and Regulatory T-cells.
Critical Rev Immunol, 38, 403-414

[144] Hayama Y, Kimura T, Takeda Y, Nada S, Koyama S, Takamatsu H, Kang S, Ito D, Maeda Y, Nishide M, Nojima S, Sarashina-Kida H, Hosokawa T, Kinehara Y, Kato Y, Nakatani T, Nakanishi Y, Tsuda T, Koba T, Okada M and Kumanogoh A. (2018).
Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
J Immunol, 200, 3790

[143] Hao F, Kondo K, Itoh T, Ikari S, Nada S, Okada M and Noda T. (2018).
Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site.
J Cell Sci, 131

2017

[142] Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsu, H., Nakayama, KI., Li, S., Standley DM., Yamashita, E., Nakagawa, A. and Okada, M. (2017).
Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nature Communications, 8, 1625

[141] Hosokawa, T., Kimura, T., Nada, S., Okuno, T., Ito, D., Kang, S., Nojima, S., Yamashita, K., Nakatani, T., Hayama, Y., Kato, Y., Kinehara, Y., Nishide, M., Mikami, N., Koyama, S., Takamatsu, H., Okuzaki, D., Ohkura, N., Sakaguchi, S., Okada, M. and Kumanogoh, A. (2017).
Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.
J Immunol, 199, 2008-2019

2016

[140] Kimura, T., Nada, S., Takegahara, N., Okuno, T., Nojima, S., Kang, S., Ito, D., Morimoto, K., Hosokawa, T., Hayama, Y., Mitsui, Y., Sakurai, N., Sarashina-Kida, H., Nishide, M., Maeda, Y., Takamatsu, H., Okuzaki, D., Yamada, M., Okada, M. and Kumanogoh, A. (2016).
Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.
Nature Communications, 7, 13130

[139] Komiya, Y., Onodera, Y., Kuroiwa, M., Nomimura, S., Kubo, Y, Choo, JJ, Kajiwara, K, Nada S., Sabe, H. and Okada, M. (2016).
The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition.
Oncogenesis, 5, e258

[138] Yao, Y., Wang, J., Yoshida, S., Nada, S., Okada, M. and Inoki, K. (2016).
Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function.
J Am Soc Nephrol, 27, e258

[137] Hashimoto, A., Oikawa, T., Hashimoto, S., Sugino, H., Yoshikawa, A., Otsuka, Y., Handa, H., Onodera, Y., Nam, JM, Oneyama, C., Okada, M., Fukuda, M. and Sabe, H. (2016).
P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.
J Cell Sci, 213, 81-95

[136] Matsuyama, R., Okuzaki, D., Okada, M. and Oneyama, C. (2016).
miR-27b suppresses tumor progression by regulating ARFGEF1 and the focal adhesion signaling.
Cancer Sci, 107, 28-35

[135] Oneyama, C., Yoshikawa, Y., Ninomiya, Y., Iino, T., Tsukita, S. and Okada, M. (2016).
Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression.
Oncogene, 35, 501-12

2015

[134] Oneyama, C. and Okada, M. (2015).
MicroRNAs as the fine-tuners of Src oncogenic signaling. (Review)
J Biochem 157, 431-8.

[133] Kakumoto, K., Ikeda, J., Okada, M., Morii, E. and Oneyama, C. (2015).
mLST8 promotes mTOR-mediated tumor progression.
PLoS One 8, e80300.

2014

[132] Saitou, S., Kajiwara, K., Oneyama, C., Suzuki, T. and Okada, M. (2014). (* Equal contribution)
Roles of Raft-anchored Adaptor Cbp/PAG1 in Spatial Regulation of c-Src Kinase.
PLoS One 9, e93470.

[131] Mori, S., Nada, S., Kimura, H., Tajima, S., Takahashi, Y. Kitamura, A., Oneyama, C. and Okada, M. (2014).
The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase.
PLoS One 9, e88891.

[130] Nada, S., Mori, S., Takahashi, Y. and Okada, M. (2014).
p18/LAMTOR1: A Late Endosome/Lysosome-Specific Anchor Protein for the mTORC1/MAPK Signaling Pathway.
Method Enzymol 535, 249-63.

[129] Kajiwara, K., Yamada, T., Bamba, T., Fukusaki, E., Imamoto, F., Okada, M. and Oneyama, C. (2014).
c-Src-induced activation of ceramide metabolism impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions.
Biochem J 458, 81-93.

2013

[128] Oneyama, C., Kito, Y., Asai, R., Ikeda, J., Yoshida, T., Okuzaki, D., Kokuda, R., Kakumoto, K., Takayama, K., Inoue, S., Morii, E. and Okada, M. (2013).
MiR-424/503-mediated Rictor upregulation promotes tumor progression.
PLoS One 8, e80300

[127] Soma-Nagae, T., Nada, S., Kitagawa, M., Takahashi, Y., Mori, S., Oneyama, C. and Okada, M. (2013).
The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes.
J Cell Sci 126, 3575-3584.

[126] Tanaka, H., Akagi, KI., Oneyama, C., Tanaka, M., Sasaki, Y., Kanou, T., Lee, YH., Yokogawa, D., Dobenecker, MW., Nakagawa, A., Okada, M. and Ikegami, T. (2013).
Identification of a new interaction mode between the Src homology 2 (SH2) domain of C-terminal Src kinase (Csk) and Csk-binding protein (Cbp)/phosphoprotein associated with glycosphingolipid microdomains (PAG).
J Biol Chem 288, 15240-15254.

[125] Sekino-Suzuki, N., Yuyama, K., Miki, T., Kaneda, M., Suzuki, H., Yamamoto, N., Yamamoto, T., Oneyama, C., Okada, M. and Kasahara, K. (2013).
Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones.
J Nuerochem 124, 514-522.

2012

[124] Okada, M. (2012).
Regulation of the SRC family kinases by Csk.
Int J Biol Sci 8, 1385-1397.

[123] Masuda, H., Nakamura, K., Takata, N., Itoh, B., Hirose, T., Moribe, H., Mekada, E. and Okada, M. (2012).
MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.
FEBS Lett 586, 740-746.

[122] Takahashi, Y., Nada, S., Mori, S., Soma-Nagae, T., Oneyama, C. and Okada, M. (2012).
The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes.
Biochem Biophys Res Commun 417, 1151-1157.

[121] Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M. and Minami, Y. (2012).
Dissection of Wnt5a-Ror2 Signaling Leading to Matrix Metalloproteinase (MMP-13) Expression.
J Biol Chem 287, 1588-1599.

[120] Oneyama, C., Morii, E., Okuzaki, D., Takahashi, Y., Ikeda, J., Wakabayashi, N., Akamatsu, H., Tsujimoto, M., Nishida, T., Aozasa, K. and Okada, M. (2012).
MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression.
Oncogene 31, 1623-1635.

2011

[119] Yoshida, S., Hong, S., Suzuki, T., Nada, S., Mannan, AM., Wang, J., Okada, M., Guan, KL., and Inoki, K. (2011).
Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.
J Biol Chem 286, 32651-32660.

[118] Oneyama, C., Ikeda, J., Okuzaki, D., Suzuki, K., Kanou, T., Shintani, Y., Morii, E., Okumura, M., Aozasa, K. and Okada, M. (2011).
MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.
Oncogene 30, 3489-3501.

[117] Kuroiwa, M., Oneyama, C., Nada, S. and Okada, M. (2011).
The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.
J Cell Sci 124, 1726-1738.

[116] Suzuki, K., Oneyama, C., Kimura, H., Tajima, S. and Okada, M. (2011).
Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway.
J Biol Chem 286, 15698-15706.

[115] Kanou, T., Oneyama, C., Kawahara, K., Okimura, A., Ohta, M., Ikeda, N., Shintani, Y., Okumura, M. and Okada, M. (2011).
The Transmembrane Adaptor Cbp/PAG1 Controls the Malignant Potential of Human Non-Small Cell Lung Cancers That Have c-Src Upregulation.
Mol Cancer Res 9, 103-114.

[114] Mukai, E., Fujimoto, S., Sato, H., Oneyama, C., Kominato, R., Sato, Y., Sasaki, M., Nishi, Y., Okada, M. and Inagaki, N. (2011).
Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.
Diabetes 60, 218-226.

2010

[113] Hikita, T., Oneyama, C. and Okada, M. (2010).
Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.
Genes Cells 15, 1051-1062.

[112] Matsubara, T., Ikeda, F., Hata, K., Nakanishi, M., Okada, M., Yasuda, H., Nishimura, R. and Yoneda, T. (2010).
Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts.
J Bone Miner Res 25, 1068-1076.

[111] Watari, A., Iwabe, N., Masuda, H. and Okada, M. (2010).
Functional transition of Pak proto-oncogene during early evolution of metazoans.
Oncogene 29, 3815-3826.

[110] Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, AL., Nada, S. and Sabatini, DM. (2010).
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Cell 141, 290-303.

2009

[109] Oneyama, C., Iino, T., Saito, K., Suzuki, K., Ogawa, A. and Okada, M. (2009).
Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain.
Mol Cell Biol 29, 6462-6472.

[108] Inoue, K., Sone, T., Oneyama, C., Nishiumi, F., Kishine, H., Sasaki, Y., Andoh, T., Okada, M., Chesnut, JD. and Imamoto, F. (2009).
A versatile nonviral vector system for tetracycline-dependent one-step conditional induction of transgene expression.
Gene Therapy 16, 1383-1394.

[107] Enomoto, M., Hayakawa, S., Itsukushima, S., Ren, DY., Matsuo, M., Tamada, K., Oneyama, C., Okada, M., Takumi, T., Nishita, M. and Minami, Y. (2009).
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.
Oncogene 28, 3197-3208.

[106] Takata, N., Itoh, B., Misaki, K., Hirose, T., Yonemura, S. and Okada, M. (2009).
Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans.
Genes Cells 14, 381-93.

[105] Nada, S., Hondo, A., Kasai, A., Koike, M., Saito, K., Uchiyama, Y. and Okada, M. (2009).
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.
EMBO J 28, 477-89.

2008

[104] Yamazaki, Y., Umeda, K., Wada, M., Nada, S., Okada, M., Tsukita, S. and Tsukita, S. (2008).
ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens.
Mol Biol Cell 19, 3801-11.

[103] Takatsuka, A., Yagi, R., Koike, M., Oneyama, C., Nada, S., Schmedt, C., Uchiyama, Y. and Okada, M. (2008).
Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.
Dev Biol 315, 474-88.

[102] Oneyama, C., Hikita, T., Enya, K., Dobenecker, M.W., Saito, K., Nada, S., Tarakhovsky, A. and Okada, M. (2008).
The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src.
Mol Cell 30, 426-36.

[101] Oneyama, C., Hikita, T., Nada, S. and Okada, M. (2008).
Functional dissection of transformation by c-Src and v-Src.
Genes Cells 13, 1-12.

[100] Nakaishi, A., Hirose, M., Yoshimura, M., Oneyama, C., Saito, K., Kuki, N., Matsuda, M., Honma, N., Ohnishi, H., Matozaki, T., Okada, M., and Nakagawa, A. (2008).
Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47.
J Mol Biol 375, 650-60.

2007

[99] Yagi, R., Waguri, S., Sumikawa, Y., Nada, S., Oneyama, C., Itami, S., Schmedt, C., Uchiyama, Y. and Okada, M. (2007).
C-terminal Src kinase controls development and maintenance of mouse squamous epithelia.
EMBO J 26, 1234-44.

[98] Saito, K., Enya, K., Oneyama, C., Hikita, T. and Okada, M. (2007).
Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit.
Biochem Biophys Res Commun 366, 969-975.

[97] Rathore, VB., Okada, M., Newman, PJ. and Newman, DK. (2007).
Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.
Biochem J 403, 275-81.

[96] Kotani, T., Morone, N., Yuasa, S., Nada, S. and Okada, M. (2007).
Constitutive activation of neuronal Src causes aberrant dendritic morphogenesis in mouse cerebellar Purkinje cells.
Neurosci Res 57, 210-9.

[95] Cantarelli, V., Kodama, T., Nijstad, N., Abolghait, S., Nada, S., Okada, M., Iida, T. and Honda, T. (2007).
Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP.
Cell Microbiol. 9, 1782-1795.

2006

[94] Segawa, Y., Suga, H., Iwabe, N., Oneyama, C., Akagi, T., Miyata, T. and Okada, M. (2006).
Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals.
Proc Natl Acad Sci U S A 103, 12021-6.

[93] Nagata, A., Ohnishi, H., Yoshimura, M., Ogawa, A., Ujita, S., Adachi, H., Okada, M., Matozaki, T. and Nakagawa, A. (2006).
Crystallization and preliminary X-ray analysis of rat SHPS-1.
Acta Crystallogr Sect F Struct Biol Cryst Commun 62, 189-91.

[92] Kogata, N., Arai, Y., Pearson, JT., Hashimoto, K., Hidaka, K., Koyama, T., Somekawa, S., Nakaoka, Y., Ogawa, M., Adams, RH., Okada, M. and Mochizuki, N. (2006).
Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization.
Circ Res 98, 897-904.

[91] Hashimoto, S., Hirose, M., Hashimoto, A., Morishige, M., Yamada, A., Hosaka, H., Akagi, K., Ogawa, E., Oneyama, C., Agatsuma, T., Okada, M., Kobayashi, H., Wada, H., Nakano, H., Ikegami, T., Nakagawa, A. and Sabe, H. (2006).
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.
Proc Natl Acad Sci U S A 103, 7036-41.

2005

[90] Nishiuchi, R., Sanzen, N., Nada, S., Sumida, Y., Wada, Y., Okada, M., Takagi, J., Hasegawa, H. and Sekiguchi, K. (2005).
Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151.
Proc Natl Acad Sci U S A 102, 1939-44.

[89] Kuwako, K., Hosokawa, A., Nishimura, I., Uetsuki, T., Yamada, M., Nada, S., Okada, M. and Yoshikawa, K. (2005).
Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival.
J Neurosci 25, 7090-9.

[88] Kasai, A., Shima, T. and Okada, M. (2005).
Role of Src family tyrosine kinases in the down-regulation of epidermal growth factor signaling in PC12 cells.
Genes Cells 10, 1175-87.

[87] Itoh, B., Hirose, T., Takata, N., Nishiwaki, K., Koga, M., Ohshima, Y. and Okada, M. (2005).
SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.
Development 132, 5161-72.

[86] Dobenecker, M.W., Schmedt, C., Okada, M. and Tarakhovsky, A. (2005).
The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function.
Mol Cell Biol 25, 10533-42.

2004

[85] Rengifo-Cam, W., Konishi, A., Morishita, N., Matsuoka, H., Yamori, T., Nada, S. and Okada, M. (2004).
Csk defines the ability of integrin-mediated cell adhesion and migration in human colon cancer cells: implication for a potential role in cancer metastasis.
Oncogene 23, 289-97.

[84] Matsuoka, H., Nada, S. and Okada, M. (2004).
Mechanism of Csk-mediated down-regulation of Src family tyrosine kinases in epidermal growth factor signaling.
J Biol Chem 279, 5975-83.

[83] Fukuhara, T., Shimizu, K., Kawakatsu, T., Fukuyama, T., Minami, Y., Honda, T., Hoshino, T., Yamada, T., Ogita, H., Okada, M. and Takai Y. (2004).
Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG.
J Cell Biol 166, 393-405.

2003

[82] Yamada, S., Takayama, Y., Seki, T., Okada, M. and Nagai, K. (2003).
Changes in L1 and NCAM expression in the rat suprachiasmatic nucleus during growth and after orbital enucleation.
Brain Res Dev Brain Res 143, 189-98.

[81] Tsutsumi, R., Higashi, H., Higuchi, M., Okada, M. and Hatakeyama, M. (2003).
Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.
J Biol Chem 278, 3664-70.

[80] Shimizu, K., Okada, M., Nagai, K. and Fukada, Y. (2003).
Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway.
J Biol Chem 278, 14920-5.

[79] Shima, T., Nada, S. and Okada, M. (2003).
Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts.
Proc Natl Acad Sci U S A 100, 14897-902.

[78] Nada, S., Shima, T., Yanai, H., Husi, H., Grant, S.G., Okada, M. and Akiyama, T. (2003).
Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn.
J Biol Chem 278, 47610-21.

[77] Hirose, T., Koga, M., Ohshima, Y. and Okada, M. (2003).
Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.
FEBS Lett 534, 133-8.

[76] Hamada, K., Kohno, S., Iwamoto, M., Yokota, H., Okada, M., Tagawa, M., Hirose, S., Yamasaki, K., Shirakata, Y., Hashimoto, K. and Ito, M. (2003).
Identification of the human IAI.3B promoter element and its use in the construction of a replication-selective adenovirus for ovarian cancer therapy.
Cancer Res 63, 2506-12.

[75] Gu, J., Nada, S., Okada, M. and Sekiguchi, K. (2003).
Csk regulates integrin-mediated signals: involvement of differential activation of ERK and Akt.
Biochem Biophys Res Commun 303, 973-7.

2002

[74] Yasuda, K., Nagafuku, M., Shima, T., Okada, M., Yagi, T., Yamada, T., Minaki, Y., Kato, A., Tani-Ichi, S., Hamaoka, T. and Kosugi, A. (2002).
Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
J Immunol 169, 2813-7.

[73] Ohtake, H., Ichikawa, N., Okada, M. and Yamashita, T. (2002).
Cutting Edge: Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcepsilonRI.
J Immunol 168, 2087-90.

[72] Ogawa, A., Takayama, Y., Sakai, H., Chong, KT., Takeuchi, S., Nakagawa, A., Nada, S., Okada, M. and Tsukihara, T. (2002).
Structure of the carboxyl-terminal Src kinase, Csk.
J Biol Chem 277, 14351-4.

[71] Lowry, WE., Huang, J., Ma, YC., Ali, S., Wang, D., Williams, DM., Okada, M., Cole, PA. and Huang, XY. (2002).
Csk, a critical link of g protein signals to actin cytoskeletal reorganization.
Dev Cell 2, 733-44.

[70] Itoh, K., Sakakibara, M., Yamasaki, S., Takeuchi, A., Arase, H., Miyazaki, M., Nakajima, N., Okada, M. amd Saito, T. (2002).
Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly.
J Immunol 168, 541-4.

2001

[69] Shima, T., Okumura, N., Takao, T., Satomi, Y., Yagi, T., Okada, M. and Nagai, K. (2001).
Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin.
J Biol Chem 276, 42233-40.

[68] Matsuki, T., Kiyama, A., Kawabuchi, M., Okada, M. and Nagai, K. (2001).
A novel protein interacts with a clock-related protein, rPer1.
Brain Res 916, 1-10.

[67] Fukushi, S., Okada, M., Kageyama, T., Hoshino, F.B., Nagai, K. and Katayama, K. (2001).
Interaction of poly(rC)-binding protein 2 with the 5'-terminal stem loop of the hepatitis C-virus genome.
Virus Res 73, 67-79.

2000

[66] Takeuchi, S., Takayama, Y., Ogawa, A., Tamura, K. and Okada, M. (2000).
Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk.
J Biol Chem 275, 29183-6.

[65] Takano, A., Shimizu, K., Kani, S., Buijs, R.M., Okada, M. and Nagai, K. (2000).
Cloning and characterization of rat casein kinase 1epsilon.
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[64] Suzuki, T., Kono, H., Hirose, N., Okada, M., Yamamoto, T., Yamamoto, K. and Honda, Z. (2000).
Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.
J Immunol 165, 473-82.

[63] Shima, T., Yagi, T., Isojima, Y., Okumura, N., Okada, M. and Nagai, K. (2000).
Changes in circadian period and morphology of the hypothalamic suprachiasmatic nucleus in fyn kinase-deficient mice.
Brain Res 870, 36-43.

[62] Nakahata, Y., Okumura, N., Shima, T., Okada, M. and Nagai, K. (2000).
Light-induced tyrosine phosphorylation of BIT in the rat suprachiasmatic nucleus.
J Neurochem 74, 2436-44.z

[61] Miyazaki, T., Takayanagi, H., Isshiki, M., Takahashi, T., Okada, M., Fukui, Y., Oda, H., Nakamura, K., Hirai, H., Kurokawa, T. and Tanaka, S. (2000).
In vitro and in vivo suppression of osteoclast function by adenovirus vector-induced csk gene.
J Bone Miner Res 15, 41-51.

[60] Kawabuchi, M., Satomi, Y., Takao, T., Shimonishi, Y., Nada, S., Nagai, K., Tarakhovsky, A. and Okada, M. (2000).
Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases.
Nature 404, 999-1003.

[59] Honda, Z., Suzuki, T., Kono, H., Okada, M., Yamamoto, T., Ra, C., Morita, Y. and Yamamoto, K. (2000).
Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling.
Mol Cell Biol 20, 1759-71.

[58] Hirose, T., Kawabuchi, M., Tamaru, T., Okumura, N., Nagai, K. and Okada, M. (2000).
Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain.
Eur J Biochem 267, 2113-21.

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[1] Yumoto, N., Okada, M. and Tokushige, M. (1982). Biospecific inactivation of aspartase by L-aspartic-beta-semialdehyde. Biochem Biophys Res Commun 104, 859-66.