Recent publications

Review article

2009

83. Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol. 2009 Feb 26. [Epub ahead of print]

82. Tsuchida T, Kawai T, Akira S. Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins. Cell Res. 2009 Jan;19(1):3-4.

81. Takeuchi O, Akira S. Innate immunity to virus infection. Immunol Rev. 2009 Jan;227(1):75-86.

80. Akira S. Innate immunity to pathogens: diversity in receptors for microbial recognition. Immunol Rev. 2009 Jan;227(1):5-8.

2008

79. Kawai T, Akira S. Toll-like Receptor and RIG-I-like Receptor Signaling. Ann N Y Acad Sci. 2008 Nov;1143:1-20.

78. Takeuchi O, Akira S. RIG-I-like antiviral protein in flies. Nat Immunol. 2008 Dec;9(12):1327-1328.

77. Koyama S, Ishii KJ, Coban C, Akira S. Innate immune response to viral infection. Cytokine. 2008 Aug 9. [Epub ahead of print]

76. Ishii KJ, Akira S. Potential link between the immune system and metabolism of nucleic acids. Curr Opin Immunol. 2008 Jul 25. [Epub ahead of print]

75. Kumagai Y, Takeuchi O, Akira S. Pathogen recognition by innate receptors. J Infect Chemother. 2008 Apr;14(2):86-92. Epub 2008 Apr 30

74. Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S. Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe. 2008 Jun 12;3(6):352-63

73. Coban C, Koyama S, Takeshita F, Akira S, Ishii KJ. Molecular and cellular mechanisms of DNA vaccines. Hum Vaccin. 2008 Apr 28;4(6). [Epub ahead of print]

72. Takeda K, Akira S. Toll-like receptors. Curr Protoc Immunol. 2007 May;Chapter 14:Unit 14.12

71. Takeuchi O, Akira S. MDA5/RIG-I and virus recognition. Curr Opin Immunol. 2008 Feb 11;20(1):17-22 [Epub ahead of print]

70. Kumagai Y, Takeuchi O, Akira S. TLR9 as a key receptor for the recognition of DNA. Adv Drug Deliv Rev. 2008 Jan 3; [Epub ahead of print]

69. Uematsu S, Akira S. Toll-Like Receptors (TLRs) and Their Ligands. Handb Exp Pharmacol. 2008;183:1-20.

2007

68. Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med. 2007 Oct 26; [Epub ahead of print]

67. Takeuchi O, Akira S. Recognition of viruses by innate immunity. Immunol Rev. 2007 Dec;220(1):214-24.

66. Beutler B, Eidenschenk C, Crozat K, Imler JL, Takeuchi O, Hoffmann JA, Akira S. Genetic analysis of resistance to viral infection. Nat Rev Immunol. 2007 Oct;7(10):753-66.

65. Kawai T, Akira S. SnapShot: Pattern-Recognition Receptors. Cell. 2007 Jun 1;129(5):1024.

64. Uematsu S, Akira S . Toll-like Receptors and Type I Interferons. J Biol Chem. 2007 May 25;282(21):15319-23. Epub 2007 Mar 29.

63. Coban C, Ishii KJ, Horii T, Akira S. Manipulation of host innate immune responses by the malaria parasite. Trends Microbiol. 2007 Apr 25; [Epub ahead of print]

62. Ishii KJ, Akira S. Toll or Toll-Free Adjuvant Path Toward the Optimal Vaccine Development. J Clin Immunol. 2007 Mar 17; [Epub ahead of print]

61. Takeuchi O, Akira S . Signaling pathways activated by microorganisms. Curr Opin Cell Biol. 2007 Feb 13; [Epub ahead of print]

60. Kawai T, Akira S. TLR signaling. Semin Immunol. 2007 Jan 31; [Epub ahead of print]

59. Kawai T, Akira S. Antiviral signaling through pattern recognition receptors. J Biochem (Tokyo).2007 Feb;141(2):137-45.

2006

58. Ishii KJ, Uematsu S, Akira S. 'Toll' gates for future immunotherapy. Curr Pharm Des. 2006;12(32):4135-42.

57. Akira S. TLR signaling. Curr Top Microbiol Immunol. 2006;311:1-16.

56. Ishii KJ, Akira S. Innate immune recognition of, and regulation by, DNA. Trends Immunol. 2006 Sep 15; [Epub ahead of print]

55. Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med. 2006 Aug 10; [Epub ahead of print]

54. Jung A, Akira S. Toll-like receptors in antiviral immunity: more than just response. Future Virology, May 2006, 1(3):313-316.

53. Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol. 2006 May;117(5):979-87; quiz 988. Epub 2006 Apr 3.

52. Bhattacharjee RN, Akira S. Modifying Toll-like Receptor 9 Signaling for Therapeutic Use. Mini Rev Med Chem. 2006 Mar;6(3):287-91

51. Uematsu S, Akira S. The role of Toll-like receptors in immune disorders. Expert Opin Biol Ther. 2006 Mar;6(3):203-14.

50. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006 Feb 24;124(4):783-801.

49. Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol. 2006 Feb;7(2):131-7.

48. Kawai T, Akira S. TLR signaling. Cell Death Differ. 2006 Jan 20; [Epub ahead of print]

2005

47. Ishii KJ, Coban C, Akira S. Manifold Mechanisms of Toll-Like Receptor-Ligand Recognition. J Clin Immunol. 25:511-521.

46. Yamamoto M, Akira S. Mechanisms of innate immune responses mediated by Toll-like receptors. Clinical and Applied Immunology Reviews 5:167-83.

45. Yamamoto M, Akira S. Tir domain-containing adaptors regulate TLR signaling pathways. Advances in Experimental Medicine and Biology. 560:1-9.

44. Ishii KJ, Akira S. TLR Ignores Methylated RNA? Immunity. 23:111-113.

43. Ishii KJ, Akira S. Innate immune recognition of nucleic acids: Beyond toll-like receptors. Int J Cancer. 2005 Aug 3; [Epub ahead of print]

42. Akira S, Hemmi H. TLR Signalling and the Function of Dendritic Cells. Chem Immunol Allergy. 86:120-35

41. Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr Opin Immunol. 2005 Jun 9; [Epub ahead of print]

40. Kawai T, Akira S. Toll-like receptor downstream signaling. Arthritis Res Ther. 7:12-9.

39. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 17:1-14.

2004

38. Kaisho T, Akira S. Pleiotropic function of Toll-like receptors. Microbes Infect. 6:1388-94.

37. Ishii KJ, Akira S. Toll-like Receptors and Sepsis. Curr Infect Dis Rep. 6:361-366.

36. Takeuchi O, Hemmi H, Akira S. Interferon response induced by Toll-like receptor signaling. J Endotoxin Res. 10:252-256.

35. Akira S, Takeda K. Functions of toll-like receptors: lessons from KO mice. C R Biol. 2004 Jun;327(6):581-9.

34. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 4:499-511.

33. Takeda K, Akira S. Microbial recognition by Toll-like receptors. J Dermatol Sci. 34:73-82.

32. Takeda K, Akira S. TLR signaling pathways. Semin Immunol. 16:3-9.

31. Akira S. Toll receptor families: structure and function. Semin Immunol. 16:1-2.

30. Yamamoto M, Takeda K, Akira S. TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol. 40:861-8.

2003

29. Kaisho T, Akira S. Regulation of dendritic cell function through toll-like receptors. Curr Mol Med. 3:759-71.

28. Akira S, Sato S. Toll-like receptors and their signaling mechanisms.Scand J Infect Dis. 35:555-62.

27. Akira S. Toll-like receptor signaling. J Biol Chem. 2003 Jul 30 [Epub ahead of print]

26. Akira S, Hoshino K. Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling. J Infect Dis. 2003 Jun 15;187 Suppl 2:S356-63.

25. Kaisho T, Akira S. Regulation of dendritic cell function through Toll-like receptors. Curr Mol Med. 2003 Jun;3(4):373-85.

24. Akira S, Yamamoto M, Takeda K. Role of adapters in Toll-like receptor signalling. Biochem Soc Trans. 2003 Jun;31(3):637-42.

23. Akira S. Mammalian Toll-like receptors.Curr Opin Immunol. 15:238.

22. Takeda K, Akira S. Toll receptors and pathogen resistance. Cell Microbiol. 2003 Mar;5(3):143-53.

21. Akira S, Hemmi H. Recognition of pathogen-associated molecular patterns by TLR family.Immunol Lett. 85:85-95.

20. Takeda K, Kaisho T,Akira S. Toll-Like Receptors.Annu Rev Immunol. 2003 Jan 9 [epub ahead of print]

19. Akira S. Mammalian Toll-like receptors.Curr Opin Immunol. 15:5-11.

2002

18. Takeuchi O, Akira S. MyD88 as a bottle neck in Toll/IL-1 signaling.Curr Top Microbiol Immunol. 270:155-67.

17. Takeuchi O, Akira S. Genetic approaches to the study of Toll-like receptor function.Microbes Infect. 4:887-895.

16. Kaisho T, Akira S. Toll-like receptors as adjuvant receptors.Biochim Biophys Acta. 1589(1):1-13.

2001

15. Takeda K, Akira S. Regulation of innate immune responses by Toll-like receptors.Jpn J Infect Dis. 54:209-19.

14. Kaisho T, Akira S. Bug detectors.Nature. 414:701-703. No abstract available.

13. Takeda K, Akira S. Multi-functional roles of Stat3 revealed by conditional gene targeting.Arch Immunol Ther Exp (Warsz). 49:279-83.

12. Takeda K, Akira S. Roles of Toll-like receptors in innate immune responses.Genes Cells. 6:733-42.

11. Kaisho T, Akira S. Toll-like receptors and their signaling mechanism in innate immunity.Acta Odontol Scand. 59:124.

10. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity.Nat Immunol. 2:675.

9. Akira S. Toll-like receptors and innate immunity.Adv Immunol. 78:1-56.

8. Takeuchi O,Akira S. Toll-like receptors; their physiological role and signal transduction system.Int Immunopharmacol. 1:625.

7. Kaisho T.,S. Akira. Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice.Trends Immunol. 22:78.

2000

6. Kaisho T, Akira S. 2000. Critical roles of toll-like receptors in host defense. Crit Rev Immunol 20:393.

5. Akira S. 2000. Toll-like receptors: lessons from knockout mice. Biochem Soc Trans 28:551.

4. Akira S. 2000. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene. 19:2607.

3. Takeda K, Akira S. 2000. STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 11:199.

2. Akira S. 2000. The role of IL-18 in innate immunity. Curr Opin Immunol. 12:59.

1999

1. Akira S. 1999. Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 17:138.