Publications
(2007)
72.
Stenzel
W, Soltek S, Sanchez-Ruiz M, Akira
S, Miletic H, Schl殳er D, Deckert M.
Both TLR2 and TLR4 Are Required
for the Effective Immune Response in Staphylococcus aureus-Induced
Experimental Murine Brain Abscess.
Am J Pathol. 2007 Dec 28; [Epub ahead of print]
71. Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M,
Kudo I, Uematsu S, Akira S,
Chung UI, Nakamura K, Kawaguchi H.
Association of microsomal
prostaglandin E synthase 1 deficiency with impaired fracture healing,
but not with bone loss or osteoarthritis, in mouse models of skeletal
disorders.
Arthritis Rheum. 2007 Dec 28;58(1):172-183 [Epub ahead of print]
70. Noor S,
Goldfine H, Tucker DE, Suram S, Lenz LL, Akira S, Uematsu S, Girotti M,
Bonventre JV, Breuel K, Williams DL, Leslie CC.
Activation of cytosolic
phospholipase A2alpha in resident peritoneal macrophages by Listeria
monocytogenes involves listeriolysin O and TLR2.
J Biol Chem. 2007 Dec 14; [Epub ahead of print]
69. Goto A,
Matsushita K, Gesellchen V, Chamy LE, Kuttenkeuler D, Takeuchi O,
Hoffmann JA, Akira S,
Boutros M, Reichhart JM.
Akirins are highly conserved
nuclear proteins required for NF-kappaB-dependent gene expression in
drosophila and mice.
Nat Immunol. 2007 Dec 9; [Epub ahead of print]
68. Abdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF,
Radstake TR, Heuvelmans-Jacobs M, Akira S, Nicklin MJ,
Ribeiro-Dias F, van den Berg WB.
Stimulation of TLR2 and TLR4
differentially skews the balance of T cells in a mouse model of
arthritis.
J Clin Invest. 2007 Dec 3; [Epub ahead of print]
67. Akagi T, Saitoh T, O'Kelly J, Akira S, Gombart AF, Koeffler
HP.
Impaired response to GM-CSF and
G-CSF, and enhanced apoptosis in C/EBP{beta}-deficient hematopoietic
cells.
Blood. 2007 Dec 4; [Epub ahead of print]
66. Kawai
T, Akira S.
Signaling to NF-kappaB by
Toll-like receptors.
Trends Mol Med. 2007 Oct 26; [Epub ahead of print]
65. Yang CS, Shin DM, Lee HM, Son JW, Lee SJ, Akira S, Gougerot-Pocidalo MA,
El-Benna J, Ichijo H, Jo EK.
ASK1-p38 MAPK-p47phox
activation is essential for inflammatory responses during tuberculosis
via TLR2-ROS signalling.
Cell Microbiol. 2007 Nov 19; [Epub ahead of print]
64. Wilson NS, Young LJ, Kupresanin F, Naik SH, Vremec D, Heath WR, Akira S, Shortman K, Boyle J,
Maraskovsky E, Belz GT, Villadangos JA.
Normal proportion and
expression of maturation markers in migratory dendritic cells in the
absence of germs or Toll-like receptor signaling.
Immunol Cell
Biol. 2007 Nov 20; [Epub ahead of print]
63.
Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV,
Neish AS, Uematsu S, Akira S,
Williams IR, Gewirtz AT.
Deletion of TLR5 results in
spontaneous colitis in mice.
J Clin Invest. 2007 Nov 15; [Epub ahead of print]
62. Gasse
P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder
B, Akira S, Quesniaux
VF, Lagente V, Ryffel B, Couillin I.
IL-1R1/MyD88 signaling and the
inflammasome are essential in pulmonary inflammation and fibrosis in
mice.
J Clin Invest. 2007 Nov 8; [Epub ahead of print]
61. Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A,
Smith KD, Skerrett SJ.
Altered Inflammatory Responses
in TLR5-Deficient
Mice Infected with Legionella pneumophila.
J Immunol. 2007 Nov
15;179(10):6981-7.
60.
Sugiyama T, Hoshino K, Saito M, Yano T, Sasaki I, Yamazaki C,
Akira S, Kaisho T.
Immunoadjuvant effects of
polyadenylic:polyuridylic
acids through TLR3 and TLR7.
Int Immunol. 2007 Nov 1; [Epub ahead of
print]
59.
Takeuchi O, Akira S.
Recognition of viruses by
innate immunity.
Immunol Rev. 2007 Dec;220(1):214-24.
58. Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW.
The HTLV-I Tax oncoprotein
requires the ubiquitin conjugating enzyme Ubc13 for NF-{kappa}B
activation.
J Virol. 2007 Oct 17; [Epub ahead of print]
57. Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O,
Martinez-Sobrido L, Akira S,
Gill MA, Garcia-Sastre A, Katze MG, Gale M Jr.
DISTINCT RIG-I AND MDA5
SIGNALING BY RNA VIRUSES IN INNATE IMMUNITY.
J Virol. 2007 Oct 17; [Epub ahead of print]
56. Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, Akira S.
Lymphocytoid choriomeningitis
virus activates plasmacytoid dendritic cells and induces cytotoxic T
cell response via MyD88.
J Virol. 2007 Oct 17; [Epub ahead of print]
55. Uematsu
S, Kaisho T, Tanaka T, Matsumoto M, Yamakami M, Omori H,
Yamamoto M, Yoshimori T, Akira S.
The
C/EBPbeta Isoform 34-kDa LAP Is
Responsible for NF-IL-6-Mediated Gene Induction in Activated
Macrophages, but Is Not Essential for Intracellular Bacteria Killing.
J
Immunol. 2007 Oct 15;179(8):5378-86.
54. Beutler
B, Eidenschenk C, Crozat K, Imler JL, Takeuchi O, Hoffmann JA, Akira S.
Genetic analysis of resistance
to viral infection.
Nat Rev Immunol. 2007 Oct;7(10):753-66.
53. Ho LH,
Ohno T, Oboki K, Kajiwara N, Suto H, Iikura M, Okayama Y, Akira S, Saito H, Galli SJ,
Nakae S.
IL-33 induces IL-13 production
by mouse mast cells independently of IgE-Fc{varepsilon}RI signals.
J Leukoc Biol. 2007 Sep 19; [Epub ahead of print]
52. Koyama
S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai
T, Akira S.
Differential Role of TLR- and
RLR-Signaling in the Immune
Responses to Influenza A Virus Infection and Vaccination.
J Immunol.
2007 Oct 1;179(7):4711-20.
51.
Kang
YJ, Kusler B, Otsuka M, Hughes M, Suzuki N, Suzuki S, Yeh WC,
Akira S, Han J, Jones PP.
Calcineurin Negatively
Regulates TLR-Mediated
Activation Pathways.
J Immunol. 2007 Oct 1;179(7):4598-607.
50. Waibler
Z,
Anzaghe M, Ludwig H, Akira S,
Weiss S, Sutter G, Kalinke U.
Modified vaccinia virus Ankara
induces Toll-like receptor independent type I interferon responses.
J Virol. 2007 Sep 12; [Epub ahead of print]
49. Newman JP,
Banerjee B, Fang W, Poonepalli A, Balakrishnan L, Low GK, Bhattacharjee
RN, Akira S, Jayapal M,
Melendez AJ, Baskar R, Lee HW, Hande MP.
Short dysfunctional telomeres
impair the repair of arsenite-induced oxidative damage in mouse cells.
J Cell Physiol. 2007 Sep 11; [Epub ahead of print]
48. Biswas SK, Bist P, Dhillon MK, Kajiji T, Del Fresno C, Yamamoto M,
Lopez-Collazo E, Akira S,
Tergaonkar V.
Role for MyD88-Independent, TRIF
Pathway in Lipid A/TLR4-Induced Endotoxin Tolerance.
J Immunol. 2007 Sep 15;179(6):4083-92.
47. Bhan U, Lukacs NW, Osterholzer JJ, Newstead MW, Zeng X, Moore TA,
McMillan TR, Krieg AM, Akira S,
Standiford TJ.
TLR9 Is Required for Protective
Innate Immunity in Gram-Negative Bacterial Pneumonia: Role of Dendritic
Cells.
J Immunol. 2007 Sep 15;179(6):3937-46.
46. Bevelander M, Mayette J, Whittaker LA, Paveglio SA, Jones CC,
Robbins J, Hemenway D, Akira S,
Uematsu S, Poynter ME.
Nitrogen dioxide promotes
allergic sensitization to inhaled antigen.
J Immunol. 2007 Sep 15;179(6):3680-8.
45. Zhande R, Dauphinee SM, Thomas JA, Yamamoto M, Akira S, Karsan A.
FADD negatively regulates
lipopolysaccharide signaling by impairing IRAK1-MyD88 interaction.
Mol Cell Biol. 2007 Sep 4; [Epub ahead of print]
44. Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H,
Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.
Enhanced TLR-mediated NF-IL6
dependent gene expression by Trib1 deficiency.
J Exp Med. 2007 Aug 27; [Epub ahead of print]
43. Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa
K, Kawai T, Akira S.
Alveolar Macrophages Are the
Primary Interferon-alpha Producer in Pulmonary Infection with RNA
Viruses.
Immunity. 2007 Aug;27(2):240-52.
42. Tezuka H,
Abe Y, Iwata M, Takeuchi H, Ishikawa H, Matsushita M, Shiohara T, Akira S, Ohteki
T.
Regulation of IgA production by
naturally occurring TNF/iNOS-producing dendritic cells.
Nature. 2007 Aug 23;448(7156):929-33.
41. Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ,
Ishii KJ, Kawai T, Akira S,
Suzuki K, Okuda K.
The Atg5 Atg12 conjugate
associates with innate antiviral immune responses.
Proc Natl Acad Sci U S A. 2007 Aug 20; [Epub ahead of print]
40. Kim
HS, Han MS,
Chung KW, Kim S, Kim E, Kim MJ, Jang E, Lee HA, Youn J, Akira S, Lee MS.
Toll-like Receptor 2 Senses beta-Cell
Death and Contributes to the Initiation of Autoimmune Diabetes.
Immunity. 2007 Aug 14; [Epub ahead of print]
39. Sakamori
R, Takehara T, Ohnishi C, Tatsumi T, Ohkawa K, Takeda K, Akira S, Hayashi N.
Signal transducer and activator
of transcription 3 signaling within hepatocytes attenuates systemic
inflammatory response and lethality in septic mice.
Hepatology. 2007 Aug 17; [Epub ahead of print]
38. Li
J, Song W,
Czerwinski DK, Varghese B, Uematsu S, Akira S, Krieg
AM, Levy R.
Lymphoma Immunotherapy with CpG
Oligodeoxynucleotides
Requires TLR9 Either in the Host or in the Tumor Itself.
J Immunol.
2007 Aug 15;179(4):2493-500.
37. Lang KS, Navarini AA, Recher M, Lang PA,
Heikenwalder M, Stecher B, Bergthaler A, Odermatt B, Akira S, Honda K, Hengartner
H, Zinkernagel RM.
MyD88 protects from lethal
encephalitis during infection with vesicular stomatitis virus.
Eur J Immunol. 2007 Aug 2; [Epub ahead of print]
36. Han
JH, Akira S, Calame K,
Beutler B, Selsing E, Imanishi-Kari T.
Class
Switch Recombination and Somatic Hypermutation in Early Mouse B Cells
Are Mediated by B Cell and Toll-like Receptors.
Immunity. 2007 Jul 18; [Epub ahead of print]
35. Kuroda E, Noguchi J, Doi T, Uematsu S, Akira S, Yamashita U.
IL-3 is an important
differentiation factor for the development of prostaglandin
E(2)-producing macrophages between C57BL/6 and BALB/c mice.
Eur J Immunol. 2007 Jul 12; [Epub ahead of print]
34. Saha S, Takeshita F, Matsuda T, Jounai N,
Kobiyama K, Matsumoto T, Sasaki S, Yoshida A, Xin KQ, Klinman DM,
Uematsu S, Ishii KJ, Akira S,
Okuda K.
Blocking of the TLR5 Activation
Domain Hampers Protective Potential of Flagellin DNA Vaccine.
J Immunol. 2007 Jul 15;179(2):1147-54.
33. Puthalakath H, O'reilly LA, Gunn P, Lee L,
Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J,
Motoyama N, Gotoh T, Akira S,
Bouillet P, Strasser A.
ER Stress Triggers Apoptosis by
Activating BH3-Only Protein Bim.
Cell. 2007 Jun 29;129(7):1337-49.
32. Ikeda F, Hecker CM, Rozenknop A, Nordmeier
RD, Rogov V, Hofmann K, Akira S,
Dotsch V, Dikic I.
Involvement of the
ubiquitin-like domain of TBK1/IKK-i kinases in regulation of
IFN-inducible genes.
EMBO J. 2007 Jun 28; [Epub ahead of print]
31. Chen CJ, Kono H, Golenbock D, Reed G, Akira
S,
Rock
KL.
Identification of a key pathway
required for the sterile inflammatory response triggered by dying cells.
Nat Med. 2007 Jun 17; [Epub ahead of print]
30. Abe T, Kaname Y, Hamamoto I, Tsuda Y, Wen
X, Taguwa S, Moriishi K, Takeuchi O, Kawai T, Kanto T, Hayashi N, Akira
S,
Matsuura
Y.
Hepatitis C Virus Nonstructural
Protein 5A Modulates TLR-MyD88-Dependent Signaling Pathway in the
Macrophage Cell Lines.
J Virol. 2007 Jun 13; [Epub ahead of print]
29. Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira
S,
Savan R, van Echo D,
Fitzgerald KA, Young HA, Ching LM, Vogel SN.
The chemotherapeutic agent DMXAA
potently and specifically activates the TBK1-IRF-3 signaling axis.
J Exp Med. 2007 Jun 11; [Epub ahead of print]
28. Kawai T, Akira
S.
SnapShot: Pattern-Recognition
Receptors.
Cell. 2007 Jun
1;129(5):1024.
27. Shimada N,
Coban C, Takeda Y, Mizu M, Minari J, Anada T, Torii Y, Shinkai S, Akira
S, Ishii KJ, Sakurai K.
A Polysaccharide
Carrier to Effectively Deliver Native Phosphodiester CpG DNA to
Antigen-Presenting
Cells.
Bioconjug Chem.
2007 May 27; [Epub ahead of print]
26. Bobacz
K, Sunk IG, Hofstaetter JG, Amoyo L, Toma CD, Akira
S, Weichhart T, Saemann M,
Smolen
JS.
Toll-like receptors
and chondrocytes: The lipopolysaccharide-induced decrease in cartilage
matrix synthesis is dependent on the presence of toll-like receptor 4
and
antagonized by bone morphogenetic protein 7.
Arthritis Rheum.
2007 May 25;56(6):1880-1893 [Epub ahead of print]
25. Yasuda K,
Richez C, Maciaszek JW, Agrawal N, Akira
S, Marshak-Rothstein A,
Rifkin IR.
Murine Dendritic
Cell Type I IFN Production Induced by Human IgG-RNA Immune Complexes Is
IFN Regulatory Factor (IRF)5 and IRF7 Dependent and Is Required for
IL-6
Production.
J Immunol. 2007
Jun 1;178(11):6876-85.
24. Imanishi T,
Hara H, Suzuki S, Suzuki N, Akira
S, Saito T.
Cutting Edge:
TLR2 Directly Triggers Th1 Effector Functions.
J Immunol. 2007
Jun 1;178(11):6715-9.
23. Shim
DH, Chang SY, Park SM, Jang H, Carbis R, Czerkinsky C, Uematsu S, Akira
S, Kweon MN.
Immunogenicity
and protective efficacy offered by a ribosomal-based vaccine from
Shigella
flexneri 2a.
Vaccine. 2007
Apr 20; [Epub ahead of print]
22. Ramesh G,
Zhang B, Uematsu S, Akira
S,
Reeves WB.
Endotoxin and
cisplatin synergistically induce renal dysfunction and cytokine
production
in mice.
Am J Physiol
Renal Physiol. 2007 May 9; [Epub ahead of print]
21. Cook P, Totemeyer
S, Stevenson C, Fitzgerald KA, Yamamoto M, Akira
S, Maskell DJ, Bryant CE.
Salmonella-induced
SipB-independent cell death requires Toll-like receptor-4 signalling
via
the adapter proteins Tram and Trif.
Immunology. 2007
May 9; [Epub ahead of print]
20. Kawagoe T,
Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira
S.
Essential role
of IRAK-4 protein and its kinase activity in Toll-like receptor-
mediated
immune responses but not in TCR signaling.
J Exp Med. 2007
May 7; [Epub ahead of print]
19. Coban C, Ishii
KJ, Horii T, Akira S.
Manipulation
of host innate immune responses by the malaria parasite.
Trends Microbiol.
2007 Apr 25; [Epub ahead of print]
18. Andersen-Nissen
E, Hawn TR, Smith KD, Nachman A, Lampano AE, Uematsu S, Akira
S, Aderem A.
Cutting Edge:
Tlr5-/- Mice Are More Susceptible to Escherichia coli Urinary Tract
Infection.
J Immunol. 2007
Apr 15;178(8):4717-20.
17. Uematsu S,
Akira S.
Toll-like Receptors
and Type I Interferons.
J Biol Chem.
2007 May 25;282(21):15319-23. Epub 2007 Mar 29.
16. Gack MU, Shin
YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira
S, Chen Z, Inoue S, Jung JU.
TRIM25 RING-finger
E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
Nature. 2007
Mar 28; [Epub ahead of print]
15. Ishii KJ,
Akira
S.
Toll or Toll-Free
Adjuvant Path Toward the Optimal Vaccine Development.
J Clin Immunol.
2007 Mar 17; [Epub ahead of print]
14. Miggin SM,
Palsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K,
Murphy
C, Moynagh P, Yamamoto M, Akira
S, Rothwell N, Golenbock D,
Fitzgerald
KA, O'neill LA.
NF-{kappa}B activation
by the Toll-IL-1 receptor domain protein MyD88 adapter-like is
regulated
by caspase-1.
Proc Natl Acad
Sci U S A. 2007 Feb 27;104(9):3372-7.
13. Kim D, Kim
MA, Cho IH, Kim MS, Lee S, Jo EK, Choi SY, Park K, Kim JS, Akira
S, Na HS, Oh SB, Lee SJ.
A critical role
of toll-like receptor 2 in nerve injury-induced spinal cord glial cell
activation and pain hypersensitivity.
J Biol Chem.
2007 Mar 13; [Epub ahead of print]
12. Obonyo M,
Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira
S, Guiney DG.
Deficiencies
of Myeloid differentiation factor 88, Toll-like receptor (TLR)-2, or
TLR4
produce specific defects in macrophage cytokine secretion induced by
Helicobacter
pylori.
Infect Immun.
2007 Mar 12; [Epub ahead of print]
11. Tao K, Fujii
M, Tsukumo SI, Maekawa Y, Kishihara K, Kimoto Y, Horiuchi T, Hisaeda H,
Akira
S, Kagami S, Yasutomo K.
Genetic variations
of Toll-like receptor 9 predispose to systemic lupus erythematosus in
Japanese
population.
Ann Rheum Dis.
2007 Mar 7; [Epub ahead of print]
10. Alugupalli
KR,
Akira S,
Lien E, Leong JM.
MyD88- and Bruton's
Tyrosine Kinase-Mediated Signals Are Essential for T Cell-Independent
Pathogen-Specific
IgM Responses.
J Immunol. 2007
Mar 15;178(6):3740-9.
9. Power MR, Li
B, Yamamoto M, Akira
S,
Lin TJ.
A Role of Toll-IL-1
Receptor Domain-Containing Adaptor-Inducing IFN-beta in the Host
Response
to Pseudomonas aeruginosa Lung Infection in Mice.
J Immunol. 2007
Mar 1;178(5):3170-6.
8. Jeyaseelan
S, Young SK, Fessler MB, Liu Y, Malcolm KC, Yamamoto M, Akira
S, Worthen GS.
Toll/IL-1 Receptor
Domain-Containing Adaptor Inducing IFN-beta (TRIF)-Mediated Signaling
Contributes
to Innate Immune Responses in the Lung during Escherichia coli
Pneumonia.
J Immunol. 2007
Mar 1;178(5):3153-60.
7. Takeuchi O,
Akira
S.
Signaling pathways
activated by microorganisms.
Curr Opin Cell
Biol. 2007 Feb 13; [Epub ahead of print]
6. Hamm S, Heit
A, Koffler M, Huster KM, Akira
S, Busch DH, Wagner H, Bauer
S.
Immunostimulatory
RNA is a potent inducer of antigen-specific cytotoxic and humoral
immune
response in vivo.
Int Immunol.
2007 Feb 7; [Epub ahead of print]
5. Sawaki J, Tsutsui
H, Hayashi N, Yasuda K, Akira
S, Tanizawa T, Nakanishi K.
Type 1 cytokine/chemokine
production by mouse NK cells following activation of their
TLR/MyD88-mediated
pathways.
Int Immunol.
2007 Feb 7; [Epub ahead of print]
4. Heer AK, Shamshiev
A, Donda A, Uematsu S, Akira
S, Kopf M, Marsland BJ.
TLR Signaling
Fine-Tunes Anti-Influenza B Cell Responses without Regulating Effector
T Cell Responses.
J Immunol. 2007
Feb 15;178(4):2182-91.
3. Kawai T, Akira
S.
TLR signaling.
Semin Immunol.
2007 Jan 31; [Epub ahead of print]
2. Qiao H, Sonoda
KH, Ikeda Y, Yoshimura T, Hijioka K, Jo YJ, Sassa Y, Tsutsumi-Miyahara
C, Hata Y, Akira S,
Ishibashi T.
Interleukin-18
regulates pathological intraocular neovascularization.
J Leukoc Biol.
2007 Jan 18; [Epub ahead of print]
1. Onoguchi K,
Yoneyama M, Takemura A, Akira
S, Taniguchi T, Namiki H,
Fujita T.
Virus infections
activate type I and type III interferon genes through a common
mechanism.
J Biol Chem.
2007 Jan 4; [Epub ahead of print]