木下タロウ

Profile

1981年大阪大学大学医学研究科修了（医学博士）。大阪大学医学部細菌学助手、講師、New York University School of Medicine博士研究員を経て1990年から2017年まで微生物病研究所教授。2003年から2007年まで微生物病研究所所長を務める。2007年からは大阪大学免疫学フロンティアセンター教授を兼任。2017年から現職。

Publication

(1) Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation. Wang Y et al. Nat. Commun. 2020 Feb 13;11(1):860.
(2) Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with auto inflammation Hochsmann B. et al. J Clin Invest. (2019) 129 (12):5123-5136.
(3) Mutations in PIGB cause an inherited GPI biosynthesis defect with an axonal neuropathy and metabolic abnormality in the severe cases Murakami Y. et al. (2019) Am. J. Hum. Genet., 105:384-394.
(4) Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Hirata, T ., et al. Nat. Commun. (2018) 9: 405
(5) N-Glycan dependent protein folding and endoplasmic reticulum retention regulate GPl-anchor processing. Liu, Y.- S., et al. J. Cell Biol. (2017) 217: 585-599.
(6) Phenotype-genotype correlations of PIGO deficiency with variable phenotypes from infantile lethality to mild learning difficulties Tanigawa , J ., et al. Hum. Mutat. (2017) 38:805-815.

研究室紹介