Aoshi Lab／Endowed Chair Department of Cellular Immunology
Cellular immunity imparted by T cells plays an important role against cancer, infectious diseases, allergy, and autoimmune diseases. Therefore, T cells can be used as drug targets. We investigated the basics of induction of a T cell response in our body, especially from the perspective of adjuvants, antigen-presenting cells, and T cell epitopes. We hypothesized that appropriate induction or reduction of T cell responses could help in preventing and controlling many diseases.
Effective induction of T cell responses requires appropriate sequential immunological processes, such as induction of innate immunity by adjuvants, antigen uptake/processing by the antigen-presenting cells, and recognition of the processed antigen-derived peptides (T cell epitope), bound to the MHC molecules, by T cells. However, details regarding these complex immunological processes are not fully understood.
We are trying to understand the various aspects of these complicated immunological processes from an initial innate immunity to a final adaptive immunity. We believe our research will help to control or adjust the T cell responses, depending on the health and disease condition of the patient, and thus provide an effective method to enhance the human health.
- Endowed Chair Assoc. Prof.: Taiki Aoshi
- Endowed Chair Assist. Prof.: Yumi Katayama
- 1) Microfluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice. Haseda Y., et al. PLoS One. (2020) 15(1):e0227891.
2) Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice. Munakata L., et al. J Control Release. (2019) 313:106-119.
3) Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use. Aoshi T., et al. J Immunol Res. (2015) 316364.
4) Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells. Aoshi T., et al. Immunity. (2008) 29(3):476-86.