業績

2012

Tarutani, M., K. Nakajima, Y. Uchida, M. Takaishi, N. Goto-Inoue, M. Setou T. Kinoshita, S. Sano, P. M. Elias and Y. Maeda. 2012. GPHR-dependent functions of the Golgi apparatus are essential for formation of lamellar granules and the skin barrier. J. Invest. Dermatol., in press.

Hanaoka, N., Y. Murakami, M. Nagata, S. Nagakura, Y. Yonemura, T. Sonoki, T. Kinoshita and H. Nakakuma. 2012. Persistently high quality of life conferred by coexisting congenital deficiency of terminal complement C9 in a paroxysmal nocturnal hemoglobinuria patient. Blood, in press.

Kanzawa, N., N. Shimozawa, R. J. A. Wanders, K. Ikeda, Y. Murakami, H. R. Waterham, S. Mukai, M. Fujita, Y. Maeda, R. Taguchi, Y. Fujiki and T. Kinoshita. 2012. Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata. J. Lipid Res., 53:653-663.

Murakami, Y., N. Kanzawa, K. Saito, P. M. Krawitz, S. Mundlos, P. N. Robinson, A. Karadimitris, Y. Maeda and T. Kinoshita. 2012. Mechanism for release of alkaline phosphatase caused by glycosylphosphatidylinositol deficiency in patients with hyperphosphatasia-mental retardation syndrome. J. Biol. Chem., 287:6318-6325.

Fujita, M. and T. Kinoshita. 2012. GPI-anchor remodeling: potential functions of GPI-anchors in intracellular trafficking and membrane dynamics. Biochim. Biophys. Acta, in press.

Kinoshita, T. 2012. Paroxysmal nocturnal hemoglobinuria. In Encyclopedia of life sciences. 2nd Ed., John Wiley & Sons, Ltd., Chichester.

2011

Murakami, H., Y. Wang, H. Hasuwa, Y. Maeda, T. Kinoshita and Y. Murakami. 2011. Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins. Biochem. Biophys. Res. Comm., 417:1235-1241.

Nakatani, F., Y. S. Morita, H. Ashida, K. Nagamune, Y. Maeda and T. Kinoshita. Identification of a second catalytically active trans-sialidase in Trypanosoma brucei. Biochem. Biophys. Res. Comm., 415:421-425.

Murakami, Y., N. Inoue, T. Shichishima, R. Ohta, H. Noji, Y. Maeda, J. Nishimura, Y. Kanakura and T. Kinoshita. 2011. Deregulated expression of HMGA2 contributes to clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria. Br. J. Haematol., 156:383-387.

Hazenbos, W. L. W., P. Wu, J. Eastham-Anderson, T. Kinoshita and E. J. Brown. 2011. Impaired FcｵRI stability, signaling and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins. Blood, 118:4377-4383.

Fujita, M., R. Watanabe, N. Jaensch, M. Romanova-Michaelides, T. Satoh, M. Kato, H. Riezman, Y. Yamaguchi, Y. Maeda and T. Kinoshita. 2011. Sorting of GPI-anchored proteins into ER-exit sites by p24 proteins is dependent on remodeled GPI. J Cell Biol., 194:61-75.

Maeda, Y and T. Kinoshita. 2011. Structural remodeling, trafficking and functions of glycosylphosphatidylinositol- anchored proteins. Prog. Lipid Res., 50:411-422.

Morita, Y. S., T. Fukuda, C. B. C. Sena, Y. Yamaryo-Botte, M. J. McConville and T. Kinoshita. 2011. Inositol lipid metabolism in Mycobacteria: Biosynthesis and regulatory mechanisms. Biochim. Biophys. Acta, 1810(6):630-641.

Kanakura Y, K. Ohyashiki, T. Shichishima, S. Okamoto, K. Ando, H. Ninomiya, T. Kawaguchi, S. Nakao, H. Nakakuma, J. Nishimura, T. Kinoshita, C.L. Bedrosian, M.E.Valentine, G. Khursigara, K. Ozawa and M. Omine. 2011. Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial. Int J Hematol., 93:36-46.

2010

Maeda, Y., M. Fujita and T. Kinoshita. 2010. GPI-anchor: update for biosynthesis and remodeling. Trends in Glycoscience and Glycotechnology 22: 182-193.

Maeda, Y. and T. Kinoshita. 2010. The acidic environment of the Golgi is critical for glycosylation and transport. Methods Enzymol., 480:495-510.

Krawitz, P. M., M. R. Schweiger, C. Rodelsperger, C. Marcelis, U. Kolsch, C, Meisel, F. Stephani, T. Kinoshita, Y. Murakami, S. Bauer, M. Isau, A. Fischer, A. Dahl, M. Kerick, J. Hecht, S. Kohler, M. Jaeger, J. Grunhagen, B. Jonske de Condor, S. Doelken, H. G. Brunner, P. Meinecke, E. Passarge, M. Thompson, D. E. Cole, D. Horn, T. Roscioli, S. Mundlos and P. N. Robinson. 2010. Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Nat. Gen., 42:827-829.

Morita, Y. S., Y. Yamaryo-Botte, K. Miyanagi, J. M. Callaghan, J. H. Patterson, P. K. Crellin, R. L. Coppel, H. Billman-Jacobe, T. Kinoshita and M. J. McConville. 2010. Stress-induced synthesis of phosphatidylinositol 3-phosphate in mycobacteria. J. Biol. Chem., 285:16643-16650.

Nakano, Y., M. Fujita, K. Ogino, T. Kinoshita, Y. Oda and H. Hirata. 2010. Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish Rohon-Beard neurons to respond to mechanosensory stimulation. Development, 137:1689-1698.

Sena, C. B., T. Fukuda, K. Miyanagi, S. Matsumoto, K. Kobayashi, Y. Murakami, Y. Maeda, T. Kinoshita and Y. S. Morita. 2010. Controlled expression of branch-forming mannosyltransferase is critical for mycobacterial lipoarabinomannan biosynthesis. J. Biol. Chem., 285:13326-13336.

Kaname, Y., H. Tani, C. Kataoka, M. Shiokawa, T. Abe, K. Moriishi, Y. Maeda, T. Kinoshita and Y. Matsuura. 2010. Acquisition of complement resistance through an incorporation of CD55/DAF into viral particles bearing baculovirus gp64 protein. J. Virol., 84:3210-3219.

2009

Fujita, M. and T. Kinoshita. 2009. Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins. FEBS Lett., 584:1670-1677.

Ishikawa, E., T. Ishikawa, Y. S. Morita, K. Toyonaga, H. Yamada, O. Takeuchi, T. Kinoshita, S. Akira, Y. Yoshikai and S. Yamasaki. 2009. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. Mincle is a receptor for mycobacterial glycolipid. J. Exp. Med. 206:2879-2888.

Fujita, M., Y. Maeda, M. Ra, Y. Yamaguchi, R. Taguchi and T. Kinoshita. 2009. GPI-glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. Cell, 139:352-365.

Kanzawa N., Y. Maeda, H. Ogiso, Y. Murakami, R. Taguchi, and T. Kinoshita. 2009. Peroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA, 106:17711-17716.

Kinoshita, T. and M. Fujita. 2009. Overview of GPI biosynthesis. In The Enzymes, Vol. 26, Eds. Menon, A. K., Kinoshita, T., Orlean, P. and Tamanoi, F., p1-30. Academic Press, Burlington.

Hong, Y and T. Kinoshita. 2009. Trypanosome glycosylphosphatidylinositol biosynthesis. Korean J. Parasitol., 47:197-204.

Honda, S., N. Kurita, A. Miyamoto, Y. Cho, K. Usui, K. Takeshita, S. Takahashi, T. Yasui, H. Kikutani, T. Kinoshita, T. Fujita, S. Tahara-Hanaoka, K. Shibuya and A. Shibuya. 2009. Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice. Proc. Natl. Acad. Sci. USA, 106:11230-11235.

Honda, S., H. Shirotani-Ikejima, S. Tadokoro, Y. Maeda, T. Kinoshita, Y. Tomiyama and T. Miyata 2009. Integrin-linked kinase associated with integrin activation. Blood, 113:5304-5313.

2008

Kondoh, G., H. Watanabe, Y. Tashima, Y. Maeda and T. Kinoshita. 2009. Testicular Angiotensin-Converting Enzyme with Different Glycan Modification: Characterization on Glycosylphosphatidylinositol-Anchored Protein Releasing and Dipeptidase Activities. J. Biochem., 145:115-121.

Maeda, Y., T. Ide, M. Koike, Y. Uchiyama and T. Kinoshita. 2008. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Nat. Cell Biol., 10:1135-1145.

Kinoshita, T. 2008. Designing sleeping sickness control. ACS Chem. Biol., 3, 601-603.

Ferguson, M., T. Kinoshita and G. Hart. 2008. Glycosylphosphatidylinositol anchors. In Essentials of Glycobiology, 2nd ed. Ed. Varki, A.; Cummings, R.D.; Esko, J.D.; Freeze, H.H.; Stanley, P.; Bertozzi, C.R.; Hart, G.W.; Etzler, M.E., Cold Spring Harbor Laboratory Press.

Noisakran, S., Dechtawewat, T., Sengsai, S., Avirutnan, P., Kinoshita, T., Siripanyaphinyo, U., Puttikhunt, P., Kasinrerk, W., Malasit, P. and Sittisombut, N. 2008. Association of dengue virus NS1 protein with lipid rafts. J. Gen. Virol. 89:2492-2500.

Tang, C., H. Yamada, K. Shibata, N. Maeda, S. Yoshida, W. Wajjwalku, N. Ohara, T. Yamada, T. Kinoshita, and Y. Yoshikai, 2008, Efficacy of recombinant Bacille Calmette-Guerin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis. J Infect Dis, 197:1263-1274.

Kinoshita, T., M. Fujita and Y. Maeda. 2008. Biosynthesis, remodeling and functions of mammalian GPI-anchored proteins: recent progress. J. Biochem., 144:287-294.

Maeda, Y. and T. Kinoshita. 2008. Dolichol-phosphate mannose synthase: structure, function and regulation. Biochim. Biophys. Acta, 1780:861-868.

Murakami, Y. and T. Kinoshita. 2008. Research in Japan has contributed to the understanding of GPI anchor deficiency. In Glycoscience Lab Manual. Ed. N. Taniguchi, p183-185, Springer, Tokyo.

Maeda, Y. and T. Kinoshita. 2008. GPI anchor biosynthesis and related genes in mammalian cells. In Glycoscience Lab Manual. Ed. N. Taniguchi, p289-292, Springer, Tokyo.

2007

Takida, S., Y. Maeda and T. Kinoshita. 2007. Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane. Biochem. J., 409:555-562.

Kinoshita, T., Y. Murakami and Y.S. Morita. 2007. Diseases associated with GPI anchors. In Comprehensive Glycoscience. Ed. J. P. Kamerling, p393-419, Elsevier Ltd., Amsterdam.

Ueda, Y., R. Yamaguchi, M. Ikawa, M. Okabe, E. Morii, Y. Maeda and T. Kinoshita. 2007. PGAP1 knockout mice show otocephaly and male infertility. J. Biol. Chem., in press.

Kim Y.U., H. Ashida, K. Mori, Y. Maeda, Y. Hong, and T. Kinoshita. 2007. Both mammalian PIG-M and PIG-X are required for growth of GPI14-disrupted yeast. J. Biochem. 2007 May 22; [Epub ahead of print]

Shimamura, M., Y.-Y. Huang, N. Okamoto, Y. Watanabe, Y. Murakami, T. Kinoshita, Y. Hirabayashi, C. Murakata, Y. Ito and T. Ogawa. 2007. Glycolipids with nonreducing end α-mannosyl residues that have the potential to activate invariant Vα19 NKT cells. FEBS J., 274:2921-2932.

Houjou, T., J.　Hayakawa, R. Watanabe, Y. Tashima, Y. Maeda, T.　Kinoshita and R. Taguchi. 2007. Changes in molecular species profiles of glycosylphosphatidylinositol-anchor precursors in early stages of biosynthesis. J. Lipid Res., 48:1599-1606.

Almeida A.M., Y. Murakami, A. Baker, Y. Maeda, I.A.G. Roberts, T. Kinoshita, D. M. Layton, and A. Karadimitris. 2007. Targeted therapy for inherited GPI deficiency. N. Engl. J. Med., 356:1641-1647.

Maeda Y, Tashima Y, Houjou T, Fujita M, Yoko-O T, Jigami Y, Taguchi R, and Kinoshita T. 2007. Fatty Acid Remodeling of GPI-anchored Proteins Is Required for Their Raft Association. Mol. Biol. Cell, 18:1497-1506.

2006

Shin DJ, Kang JY, Kim YU, Yoon JS, Choy HE, Maeda Y, Kinoshita T, and Hong Y. 2006. Isolation of new CHO cell mutants defective in CMP-sialic acid biosynthesis and transport. Mol Cells, 22:343-52.

Maeda, Y., Ashida, H., and Kinoshita, T. 2006. CHO glycosylation mutants: GPI anchor. Methods Enzymol. 416:182-205.

Inoue N, Izui-Sarumaru T, Murakami Y, Endo Y, Nishimura JI, Kurokawa K, Kuwayama M, Shime H, Machii T, Kanakura Y, Meyers G, Wittwer C, Chen Z, Babcock W, Frei-Lahr D, Parker CJ, Kinoshita T. 2006. Molecular basis of clonal expansion of hematopoiesis in two patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood, 108:4232-6.

Morita YS, Sena CB, Waller RF, Kurokawa K, Sernee MF, Nakatani F, Haites RE, Billman-Jacobe H, McConville MJ, Maeda Y, Kinoshita T. 2006. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria. J Biol Chem., 281:25143-55.

Almeida AM, Murakami Y, Layton DM, Hillmen P, Sellick GS, Maeda Y, Richards S, Patterson S, Kotsianidis I, Mollica L, Crawford DH, Baker A, Ferguson M, Roberts I, Houlston R, Kinoshita T, Karadimitris A. 2006. Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. Nat Med., 12:846-851.

Hong, Y., Nagamune, K., Morita, Y.S., Nakatani, F., Ashida, H., Maeda, Y., and Kinoshita, T. 2006. Removal or maintenance of inositol-linked acyl chain in GPI is critical in trypanosome life cycle. J. Biol. Chem., 281:11595-11602.

Tashima, Y., Taguchi, R., Murata, C., Ashida, H., Kinoshita, T., and Maeda, Y., 2006. PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins. Mol. Biol. Cell, 17:1410-1420.

Wanachiwanawin, W., Siripanyaphinyo, U., Piyawattanasakul, N. and T. Kinoshita. 2006. A cohort study of nature of paroxysmal nocturnal hemoglobinuria (PNH) clones and PIG-A mutations in patients with aplastic anemia. Eur. J. Haematol., 76:502-509.

Hong, Y., Nagamune, K., Ohishi, K., Morita, Y.S., Ashida, H., Maeda, Y., and Kinoshita, T., 2006. TbGPI16 is an essential component o f GPI transamidase in Trypanosoma brucei. FEBS lett., 580:603-606.

Ashida, H., Maeda, Y. and Kinoshita, T., 2006. DPM1, the catalytic subunit of dolichol-phosphate-mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. J. Biol. Chem. 281: 896-906.

2005

Keng V.W., Yae K., Hayakawa T., Mizuno S., Uno Y., Yusa K., Kokubu C., Kinoshita T., Akagi K., Jenkins N.A., Copeland N.G., Horie K., Takeda J., 2005. Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Nat. Methods 2: 763-9.

Murakami, Y., Siripanyaphinyo, U., Hong, Y., Tashima, Y., Maeda, Y. and Kinoshita, T. 2005. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Mol. Biol. Cell, 16: 5236-5246.

Parker, C., M. Omine, S. Richards, J. Nishimura, M. Bessler, R Ware, P. Hillmen, L. Luzzatto, N. Young, T. Kinoshita, W. Rosse and G. Socie., 2005. Diagnosis and Management of Paroxysmal Nocturnal Hemoglobinuria. Blood, 106:3699-3709.

Hong, Y., J.Y. Kang, Y.U. Kim, D.-J. Shin, H.E. Choy, Y. Maeda, and T. Kinoshita., 2005. New mutant Chinese hamster ovary cell representing an unknown gene for attachment of glycosylphosphatidylinositol to proteins. Biochem. Biophys. Res. Commn., 335: 1060-1069.

Kubata, B.K., Nagamune, K., Murakami, N., Merkel, P., Kabututu, Z., Martin, S.K., Kalulu, T.M., Mustakuk, H., Yoshida, M., Ohnishi-Kameyama, M., Kinoshita, T., Duszenko, M. and Urade, Y., 2005. Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei. Int. J. Parasitol. 35: 91-103.

Rungruang, T., O. Kaneko, Y. Murakami, T. Tsuboi, H. Hamamoto, N. Akimitsu, K. Sekimizu, T. Kinoshita and M. Torii., 2005. Erythrocyte surface glycosylphosphatidyl inositol anchored receptor for the malaria parasite. Mol. Biochem. Parasitol. 140: 13-21.

Kondoh, G., H. Tojo, Y. Nakatani, N. Komazawa, C. Murata, K. Yamagata, Y. Maeda, T. Kinoshita, M. Okabe, R. Taguchi and J. Takeda, 2005. Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat. Med. 11: 160-166.

Ashida, H., Y. Hong, Y. Murakami, N. Shishioh, N. Sugimoto, Y. U. Kim, Y. Maeda and T. Kinoshita, 2005. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Mol. Biol. Cell 16: 1439-1448.

Shishioh, N., Y. Hong, K. Ohishi, H. Ashida, Y. Maeda and T. Kinoshita, 2005. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. J. Biol. Chem. 280: 9728-9734.

Kang, J.Y., Y. Hong, H. Ashida, N. Shishioh, Y. Murakami, Y. S. Morita, Y. Maeda and T. Kinoshita, 2005. PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol. J. Biol. Chem. 280: 9489-9497.

2004

Tanaka, S., Y. Maeda, Y. Tashima and T. Kinoshita, 2004. Inositol-deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. J. Biol. Chem. 279: 14256-14263.

Nishimura, J., Y. Kanakura, R. E. Ware, T. Shichishima, H. Nakakuma, H. Ninomiya, C. M. DeCastro, S. Hall, A. Kanamaru, K. M. Sullivan, H. Mizoguchi, M. Omine, T. Kinoshita and W. F. Rosse, 2004. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine 83: 193-207.

Nagamune, K., A. Acosta-Serrano, H. Uemura, R. Brun, C. Kunz-Renggli, Y. Maeda, M. A. J. Ferguson and T. Kinoshita, 2004. Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors. J. Exp. Med. 199: 1445-1450.

Yusa, K., K. Horie, G. Kondoh, M. Kouno, Y. Maeda, T. Kinoshita and J. Takeda, 2004. Genome-wide phenotype analysis in ES cells by regulated disruption of the Bloom's syndrome gene. Nature 429: 896-899.

Hazenbos, W. L.W., B. E. Clausen, J. Takeda and T. Kinoshita, 2004. GPI-anchor deficiency in myeloid cells causes impaired FcgR effector functions. Blood 104: 2825-2831.

Hazenbos, W. L.W., Y. Murakami, J. Nishimura, J. Takeda and T. Kinoshita, 2004. Enhanced responses of glycosylphosphatidylinositol anchor-deficient T lymphocytes. J. Immunol. 173: 3810-3815.

2003

Inoue, N., Y. Murakami and T. Kinoshita. 2003. Molecular genetics of paroxysmal nocturnal hemoglobinuria. Int. J. Hematol. 77: 107-112.

Hong, Y., K. Ohishi, J. Y. Kang, S. Tanaka, N. Inoue, J. Nishimura, Y. Maeda and T. Kinoshita. 2003. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Mol. Biol. Cell 14: 1780-1789.

Ohishi, K., K. Nagamune, Y. Maeda and T. Kinoshita. 2003. Two subunits of glycosylphosphatidylinositol transamidase GPI8 and PIG-T form a functionally important intermolecular disulfide bridge. J. Biol. Chem. 278: 13959-13967.

Murakami, Y., U. Siripanyapinyo, Y. Hong, J. Y. Kang, S. Ishihara, H. Nakakuma, Y. Maeda and T. Kinoshita. 2003. PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor. Mol. Biol. Cell 14: 4285-4295.

Nagamune, K., K. Ohishi, H. Ashida, Y. Hong, J. Hino, K. Kangawa, N. Inoue, Y. Maeda and T. Kinoshita. 2003. GPI transamidase of Trypanosoma brucei has two novel (TTA1 and TTA2) and three common subunits. Proc. Natl. Acad. Sci. USA 100: 10682-10687.

2002

Inoue, N. and T. Kinoshita. 2002. GPI-GlcNAc transferase: Complex of PIG-A, PIG-C, PIG-H, hGPI1, and PIG-P. In Handbook of Glycosyltransferases and Related Genes., Ed. N. Taniguchi, K. Honke and M. Fukuda, p533-539, Springer-Verlag, Tokyo.

Kinoshita, T. and N. Inoue. 2002. PIG-B, GPI-Man transferase III, Man-(Ethanolaminephosphate) Man-GlcN-(Acyl) PI mannosyltransferase. In Handbook of Glycosyltransferases and Related Genes., Ed. N. Taniguchi, K. Honke and M. Fukuda, p546-549, Springer-Verlag, Tokyo.

Kinoshita, T. and N. Inoue. 2002. Relationship between aplastic anemia and paroxysmal nocturnal hemoglobinuria. Int. J. Hematol. 75: 117-122.

Kinoshita, T. 2002. Overview of paroxysmal nocturnal hemoglobinuria: Molecular genetics. In Paroxysmal nocturnal hemoglobinuria and related disorders. Ed. M. Omine and T. Kinoshita, p3-9, Springer, Tokyo.

Inoue, N., T. Izui, M. Kuwayama, J. Nishimura, K. Kurokawa, T. Machii, Y. Kanakura and T. Kinoshita. 2002. A possible intrinsic mechanism for clonal expansion of PNH abnormal cells. In Paroxysmal nocturnal hemoglobinuria and related disorders. Ed. M. Omine and T. Kinoshita, p117-126, Springer, Tokyo.

Murakami, H., H. Nagashima, Y. Takahagi, S. Miyagawa, T. Fujimura, K. Toyomura, R. Nakai, M. Yamada, T. Kurihara, T. Shigehisa, M. Okabe, T. Seya, R. Shirakura and T. Kinoshita. 2002. Transgenic pigs expressing human decay-accelerating factor regulated by porcine MCP gene promoter. Mol. Reprod. Dev. 61: 302-311.

Shams-Eldin, H., N. Azzouz, M. H. Kedees, P. Orlean, T. Kinoshita and R. T. Schwarz. 2002. Cloning and characterization of a GPI-1 homologue from Plasmodium falciparum. Mol. Biochem. Parasitol. 120: 73-81.

Nishimura, J., T. Hirota, Y. Kanakura, T. Machii, T. Kageyama, S. Doi, H. Wada, T. Masaoka, Y. Kanayama, H. Fujii, N. Inoue, M. Kuwayama, N. Inoue, K. Ohishi and T. Kinoshita. 2002. Long-term support of hematopoiesis by a single stem cell clone in patients with paroxysmal nocturnal hemoglobinuria. Blood 99: 2748-2751.

Abrami, L., M-C. Velluz, Y. Hong, K. Ohishi, A. Mehlert, M. Ferguson, T.Kinoshita and F. G. van der Goot. 2002. The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient. FEBS Let. 512: 249-254.

Nagakura, S., S. Ishihara, D. E. Dunn, J. Nishimura, T. Kawaguchi, K. Horikawa, M. Hidaka, T. Kagimoto, N. Eto, H. Mitsuya, T. Kinoshita, N. S. Young and H. Nakakuma. 2002. Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro. Blood 100: 1031-1037.

Vainauskas, S., Y. Maeda, H. Kurniawan, T. Kinoshita and A. K. Menon. 2002. Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex. J. Biol. Chem. 277: 30535-30542.

Murakami, Y., H. Kosaka, Y. Maeda, J. Nishimura, N. Inoue, K. Ohishi, M. Okabe, J. Takeda and T. Kinoshita. 2002. Inefficient response of T lymphocytes to glycosylphosphatidylinositol-negative cells: implications for paroxysmal nocturnal hemoglobinuria. Blood 100: 4116-4122.

Hong, Y., K. Ohishi, N. Inoue, J. Y. Kang, H. Shime, Y. Horiguchi, F. G. van der Goot, N. Sugimoto and T. Kinoshita. 2002. Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum a-toxin. EMBO J. 21: 5047-5056.

Yokoyama, C., T. Yabuki, M. Shimonishi, M. Wada, T. Hatae, S. Ohkawara, J. Takeda, T. Kinoshita, M. Okabe and T. Tanabe. 2002. Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. Circulation 106: 2397-2403.

2001

Kinoshita, T., M. Bessler and J. Takeda. 2000. Animal models of PNH. In PNH and the GPI-linked Proteins., Ed. N. S. Young and J. Moss, p139-158, Academic Press, San Diego.

Kinoshita, T. and N. Inoue. 2000. Dissecting and manipulating the pathway for glycosylphosphatidylinositol-anchor biosynthesis. Curr. Opin. Chem. Biol. 4: 632-638.

Maeda, Y., R. Watanabe, C. L. Harris, Y. Hong, K. Ohishi, K. Kinoshita and T. Kinoshita. 2001. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. EMBO J. 20: 250-261.

Yada, T., R. Sugiura, A. Kita, Y. Itoh, Y. Lu, Y. Hong, T. Kinoshita, H. Shuntoh and T. Kuno. 2001. Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis. J. Biol. Chem. 276: 13579-13586.

Nishimura, J., K. L. Phillips, R. E. Ware, S. Hall, L. Wilson, T. L. Gentry, T. A. Howard, Y. Murakami, M. Shibano, T. Machii, E. Gilboa, Y. Kanakura, J. Takeda, T. Kinoshita, W. F. Rosse and C. A.Smith. 2001. Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype. Blood 97: 3004-3010.

Ohishi, K., N. Inoue and T. Kinoshita. 2001. PIG-S and PIG-T, essential for GPI-anchor attachment to proteins, form a complex with GAA1 and GPI8. EMBO J. 20: 4088-4098.

Abrami, L., T. Kobayashi, T. Kinoshita, R. G. Parton and F. G. van der Goot. 2001. Cross-talk between caveolae and GPI-rich domains. J. Biol. Chem. 276: 30729-30736.

2000

Begum, N. A., Y. Murakami, S. Mikata, M. Matsumoto, M. Hatanaka, S. Nagasawa, T. Kinoshita and T. Seya. 2000. Molecular remodeling of human CD46 for xenotransplantation: designing a potent complement regulator without measles virus receptor activity. Immunology 100: 131-139.

Murakami, H., Y. Takahagi, M. Yoshitatsu, S. Miyagawa, T. Fujimura, K. Toyomura, T. Shigehisa, R. Shirakura and T. Kinoshita. 2000. Porcine MCP gene promoter directs high level expression of human DAF (CD55) in transgenic mice. Immunobiology 201: 583-597.

Ohishi, K., N. Inoue, Y. Maeda, J. Takeda, H. Riezman and T. Kinoshita. 2000. Gaa1p and Gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins. Mol. Biol. Cell 11: 1523-1533.

Kadota, Y., M. Okumura, S. Miyoshi, S. Kitagawa-Sakakida, M. Inoue, H. Shiono, Y. Maeda, T. Kinoshita, R. Shirakura and H. Matsuda. 2000. Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by Interferon-gamma (IFN-g). Clin. Exp. Immunol. 121: 59-68.

Maeda, Y., S. Tanaka, J. Hino, K. Kangawa and T. Kinoshita. 2000. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. EMBO J. 19: 2475-2482.

Hong, Y., Y. Maeda, R. Watanabe, N. Inoue, K. Ohishi and T. Kinoshita. 2000. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. J. Biol. Chem. 275: 20911-20919.

Nagamune, K., T. Nozaki, Y. Maeda, K. Ohishi, T. Fukuma, T. Hara, R. T. Schwarz, C. Sutterlin, R. Brun, H. Riezman and T. Kinoshita. 2000. Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei. Proc. Natl. Acad. Sci. USA 97: 10336-10341.

Watanabe, R., Y. Murakami, M. D. Marmor, N. Inoue, Y. Maeda, J. Hino, K. Kangawa, M. Julius and T. Kinoshita. 2000. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J. 19: 4402-4411.

Murakami, H., H. Nagashima, Y. Takahagi, T. Fujimura, S. Miyagawa, M. Okabe, T. Seya, T. Shigehisa, N. Taniguchi, R. Shirakura and T. Kinoshita. 2000. Production of transgenic pigs expressing human DAF (CD55) regulated by the porcine MCP gene promoter. Transplant. Proc. 32: 2505-2506.

1999

Takeda, J., N. Inoue and T. Kinoshita. 1999. Glycosylphosphatidylinositol (GPI)-anchor biosynthesis. Comprehensive Natural Products Chemistry., Ed. D. Barton and K. Nakanishi, vol 4, p305-318, Elsevier, Amsterdam.

Kinoshita, T., M. Bessler and J. Takeda. 1999. Animal models of paroxysmal nocturnal hemoglobinuria. Paroxysmal Nocturnal Hemoglobinuria and the GPI-linked Proteins, Ed. N. S. Young and J. Moss, Academic Press, San Diego.

Nishimura, J., Y. Murakami and T. Kinoshita. 1999. Paroxysmal nocturnal hemoglobinuria: an acquired genetic disease. Am. J. Hematol. 62: 175-182.

Azenishi, Y., E. Ueda, T. Machii, J. Nishimura, T. Hirota, M. Shibano, S. Nakao, T. Kinoshita, H. Mizoguchi and T. Kitani. 1999. CD59-deficient blood cells and PIG-A gene abnormalities in Japanese patients with aplastic anaemia. Br. J. Haematol. 104: 523-529.

Watanabe, R., K. Ohishi, Y. Maeda, N. Nakamura and T. Kinoshita. 1999. Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminyl-phosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. Biochem. J. 339: 185-192.

Inoue, N., K. Ohishi, Y. Endo, T. Fujita, J. Takeda and T. Kinoshita. 1999. Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron. Cytogenet. Cell Genet. 84: 199-205.

Hong, Y., K. Ohishi, R. Watanabe, Y. Endo, Y. Maeda and T. Kinoshita. 1999. GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis. J. Biol. Chem. 274: 18582-18588.

Murakami, Y., T. Kinoshita, Y. Maeda, T. Nakano, H. Kosaka and J. Takeda. 1999. Different roles of glycosylphosphatidylinositol in various hematopoietic cells as revealed by model mice of paroxysmal nocturnal hemoglobinuria. Blood 94: 2963-2970

Hong, Y., Y. Maeda, R. Watanabe, K. Ohishi, M. Mishkind, H. Riezman and T. Kinoshita. 1999. PIG-N, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol. J. Biol. Chem. 274: 35099-35106.

1998

Watanabe, R., N. Inoue, B. Westfall, C. H. Taron, P. Orlean, J. Takeda and T. Kinoshita. 1998. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J. 17: 877-885.

Tomita, S., N. Inoue, Y. Maeda, K. Ohishi, J. Takeda and T. Kinoshita. 1998. A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. J. Biol. Chem. 273: 9249-9254.

Takahama, Y., K. Ohishi, Y. Tokoro, T. Sugawara, Y. Yoshimura, M. Okabe, T. Kinoshita and J. Takeda. 1998. Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene. Eur. J. Immunol. 28: 2159-2166.

Maeda, Y., S. Tomita, R. Watanabe, K. Ohishi and T. Kinoshita. 1998. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells:correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. EMBO J. 17: 4920-4929.