Publications (2008)
70. Amiel E, Alonso A, Uematsu S, Akira S, Poynter ME, Berwin B.
Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis.
 J Leukoc Biol. 2008 Dec 26. [Epub ahead of print]

69. Abu-Dayyeh I, Shio MT, Sato S, Akira S , Cousineau B, Olivier M.
Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif.
PLoS Negl Trop Dis. 2008;2(12):e305. Epub 2008 Dec 23.

68. Sheahan T, Morrison TE, Funkhouser W, Uematsu S, Akira S, Baric RS, Heise MT.
MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV.
PLoS Pathog. 2008 Dec;4(12):e1000240. Epub 2008 Dec 12.

67. Kawai T, Akira S.
Toll-like Receptor and RIG-I-like Receptor Signaling.
Ann N Y Acad Sci. 2008 Nov;1143:1-20.

66. Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S.
The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.
Hepatology. 2008 Aug 14. [Epub ahead of print]

65. Saiga H, Nishimura J, Kuwata H, Okuyama M, Matsumoto S, Sato S, Matsumoto M, Akira S, Yoshikai Y, Honda K, Yamamoto M, Takeda K.
Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.
J Immunol. 2008 Dec 15;181(12):8521-7

64. Lee PY, Kumagai Y, Li Y, Takeuchi O, Yoshida H, Weinstein J, Kellner ES, Nacionales D, Barker T, Kelly-Scumpia K, van Rooijen N, Kumar H, Kawai T, Satoh M, Akira S, Reeves WH.
TLR7-dependent and Fc{gamma}R-independent production of type I interferon in experimental mouse lupus.
J Exp Med. 2008 Dec 1. [Epub ahead of print]

63. Allam R, Pawar RD, Kulkarni OP, Hornung V, Hartmann G, Segerer S, Akira S, Endres S, Anders HJ.
Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses.
Eur J Immunol. 2008 Nov 13. [Epub ahead of print]

62. Takeuchi O, Akira S.
RIG-I-like antiviral protein in flies.
Nat Immunol. 2008 Dec;9(12):1327-1328.

61. Waibler Z, Anzaghe M, Konur A, Akira S, Muler W, Kalinke U.
Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC.
 Eur J Immunol. 2008 Nov;38(11):3127-37.
60. Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y,  Akira S, Kawai T, Yoshimura A, Kobayashi T.
TNF receptor-associated factor (TRAF) 6 and MEK kinase (MEKK) 1 play a pivotal role in the retinoic-acid-inducible gene-I (RIG-I)-like helicase antiviral pathway.
J Biol Chem. 2008 Nov 4. [Epub ahead of print]

59. Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Hacker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tuting T, Hartmann G.
5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.
Nat Med. 2008 Nov 2. [Epub ahead of print]

58. Kawakami A, Osaka M, Aikawa M, Uematsu S, Akira S, Libby P, Shimokado K, Sacks FM, Yoshida M .
Toll-Like 2 Receptor Mediates Apolipoprotein CIII-Induced Monocyte Activation.
Circ Res. 2008 Oct 30. [Epub ahead of print]

57. Selvarajoo K, Takada Y, Gohda J, Helmy M, Akira S, Tomita M, Tsuchiya M, Inoue J, Matsuo K.
Signaling flux redistribution at toll-like receptor pathway junctions.
PLoS ONE. 2008;3(10):e3430.

56. Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Nature. 2008 Oct 5. [Epub ahead of print]

55. Zhu Q, Egelston C, Vivekanandhan A, Uematsu S, Akira S, Klinman DM, Belyakov IM, Berzofsky JA.
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines.
Proc Natl Acad Sci U S A. 2008 Oct 9. [Epub ahead of print]

54. Tominaga H, Maeda S, Hayashi M, Takeda S, Akira S, Komiya S, Nakamura T, Akiyama H, Imamura T. CCAAT/Enhancer-binding Protein {beta} Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF4.
Mol Biol Cell. 2008 Oct 8. [Epub ahead of print]

53. Yamazaki S, Matsuo S, Muta T, Yamamoto M, Akira S, Takeshige K.
Gene-specific requirement of a nuclear protein, Ikappa B-zeta , for promoter association of inflammatory transcription regulators.
J Biol Chem. 2008 Sep 29. [Epub ahead of print]

52. Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y.
The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
Nat Cell Biol. 2008 Sep 28. [Epub ahead of print]

51. Kariko K, Muramatsu H, Welsh FA, Ludwig J, Kato H, Akira S , Weissman D.
Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability.
Mol Ther. 2008 Sep 16. [Epub ahead of print]

50. Koyama S, Ishii KJ, Coban C, Akira S .
Innate immune response to viral infection.
Cytokine. 2008 Aug 9. [Epub ahead of print]

49. Huen MS, Huang J, Yuan J, Yamamoto M, Akira S , Ashley C, Xiao W, Chen J.
Non-canonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.
Mol Cell Biol. 2008 Aug 4. [Epub ahead of print]

48. van Zoelen MA, Yang H, Florquin S, Meijers JC, Akira S , Arnold B, Nawroth PP, Bierhaus A, Tracey KJ, van der Poll T.
ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS (RAGE) IN HMGB1 INDUCED INFLAMMATION IN VIVO.
Shock. 2008 Jul 24. [Epub ahead of print]

47. Leng X, Lin H, Ding T, Wang Y, Wu Y, Klumpp S, Sun T, Zhou Y, Monaco P, Belmont J, Aderem A, Akira S, Strong R, Arlinghaus R.
Lipocalin 2 is required for BCR-ABL-induced tumorigenesis.
Oncogene. 2008 Jul 28. [Epub ahead of print]

46. Ishii KJ, Akira S.
Potential link between the immune system and metabolism of nucleic acids.
Curr Opin Immunol. 2008 Jul 25. [Epub ahead of print]

45. Nakamura J, Fujimoto M, Yasuda K, Takeda K, Akira S , Hatayama T, Takagi Y, Nozaki K, Hosokawa N, Nagata K.
Targeted Disruption of Hsp110/105 Gene Protects Against Ischemic Stress.
Stroke. 2008 Jul 24. [Epub ahead of print]

44. Nakamura K, Miyazato A, Koguchi Y, Adachi Y, Ohno N, Saijo S, Iwakura Y, Takeda K, Akira S, Fujita J, Ishii K, Kaku M, Kawakami K.
Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei.
Microbes Infect. 2008 Jul 3. [Epub ahead of print]

43. Kumagai Y, Takeuchi O, Akira S.
Pathogen recognition by innate receptors.
J Infect Chemother. 2008 Apr;14(2):86-92. Epub 2008 Apr 30.

42. Taylor PA, Ehrhardt MJ, Lees CJ, Panoskaltsis-Mortari A, Krieg AM, Sharpe AH, Murphy WJ, Serody JS, Hemmi H, Akira S , Levy RB, Blazar BR.
TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.
Blood. 2008 Jul 9. [Epub ahead of print]

41. Herrmann JE, Imura T, Song B, Qi J, Ao Y, Nguyen TK, Korsak RA, Takeda K, Akira S, Sofroniew MV.
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury.
J Neurosci. 2008 Jul 9;28(28):7231-43.

40. Santiago-Raber ML, Kikuchi S, Borel P, Uematsu S, Akira S , Kotzin BL, Izui S.
Evidence for genes in addition to tlr7 in the yaa translocation linked with acceleration of systemic lupus erythematosus.
J Immunol. 2008 Jul 15;181(2):1556-62.

39. Kajino-Sakamoto R, Inagaki M, Lippert E, Akira S , Robine S, Matsumoto K, Jobin C, Ninomiya-Tsuji J.
Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis.
J Immunol. 2008 Jul 15;181(2):1143-52.

38. Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, Hiiragi A, Dermody TS, Fujita T, Akira S .
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
J Exp Med. 2008 Jun 30. [Epub ahead of print]

37. Tang M, Wei X, Guo Y, Breslin P, Zhang S, Zhang S, Wei W, Xia Z, Diaz M, Akira S, Zhang J.
TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice.
J Exp Med. 2008 Jun 23. [Epub ahead of print]

36. Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S .
Host innate immune receptors and beyond: making sense of microbial infections.
Cell Host Microbe. 2008 Jun 12;3(6):352-63

35. Coban C, Koyama S, Takeshita F, Akira S , Ishii KJ.
Molecular and cellular mechanisms of DNA vaccines.
Hum Vaccin. 2008 Apr 28;4(6). [Epub ahead of print]

34. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S .
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Nat Immunol. 2008 May 30. [Epub ahead of print]

33. Ohbayashi N, Okada K, Kawakami S, Togi S, Sato N, Ikeda O, Kamitani S, Muromoto R, Sekine Y, Kawai T, Akira S , Matsuda T.
Physical and functional interactions between ZIP kinase and UbcH5.
Biochem Biophys Res Commun. 2008 May 29. [Epub ahead of print]

32. Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S , Gotoh Y, Kiyono H, Miyake K.
Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
Int Immunol. 2008 May 19. [Epub ahead of print]

31. Elander N, Ungerb?ck J, Olsson H, Uematsu S, Akira S , S?derkvist P.
Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.
Biochem Biophys Res Commun. 2008 May 14. [Epub ahead of print]

30. Gratz N, Siller M, Schaljo B, Pirzada ZA, Gattermeier I, Vojtek I, Kirschning CJ, Wagner H, Akira S, Charpentier E, Kovarik P.
Group A Streptococcus activates type I interferon production and MYD88-dependent signalling without involvement of TLR2, TLR4 and TLR9.
J Biol Chem. 2008 May 14. [Epub ahead of print]

29. Koga T, Endo H, Miyamoto Y, Mukai M, Akira S , Inoue M.
IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions.
Cancer Lett. 2008 May 6. [Epub ahead of print]

28. Ueta M, Hamuro J, Ueda E, Katoh N, Yamamoto M, Takeda K, Akira S , Kinoshita S.
Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of I{kappa}B{zeta}-/- mice.
Invest Ophthalmol Vis Sci. 2008 Apr 25; [Epub ahead of print]

27. Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S.
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
Nat Immunol. 2008 Apr 27; [Epub ahead of print]

26. Takeda K, Akira S.
Toll-like receptors.
Curr Protoc Immunol. 2007 May;Chapter 14:Unit 14.12

25. Zucchini N, Bessou G, Traub S, Robbins SH, Uematsu S, Akira S , Alexopoulou L, Dalod M.
Cutting Edge: Overlapping Functions of TLR7 and TLR9 for Innate Defense against a Herpesvirus Infection.
J Immunol. 2008 May 1;180(9):5799-5803.

24. Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S , Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM.
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Cell. 2008 Apr 18;133(2):235-49

23. Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S , Low MJ, Rubinstein M, Mackenzie RG.
Stat3 is required in hypothalamic Agrp/Npy neurons for normal energy homeostasis.
Endocrinology. 2008 Apr 10; [Epub ahead of print]

22. Samuelsson C, Hausmann J, Lauterbach H, Schmidt M, Akira S , Wagner H, Chaplin P, Suter M, O'Keeffe M, Hochrein H.
Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection.
J Clin Invest. 2008 Apr 8; [Epub ahead of print]

21. Savarese E, Steinberg C, Pawar RD, Reindl W, Akira S , Anders HJ, Krug A.
Requirement of toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis.
Arthritis Rheum. 2008 Mar 27;58(4):1107-1115 [Epub ahead of print]

20. Shin OS, Isberg R, Akira S, Uematsu S, Behera AK, Hu LT.
Distinct roles for MyD88, TLR2, TLR5, and TLR9 in phagocytosis of Borrelia burgdorferi and inflammatory signaling.
Infect Immun. 2008 Mar 31; [Epub ahead of print]

19. Hirata N, Yanagawa Y, Ebihara T, Seya T, Uematsu S, Akira S , Hayashi F, Iwabuchi K, Ono? K.
Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells.
Mol Immunol. 2008 Mar 25; [Epub ahead of print]

18. Obata K, Katsura H, Miyoshi K, Kondo T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Akira S, Noguchi K.
Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury.
J Neurochem. 2008 Mar 16; [Epub ahead of print]

17. Nakamura K, Miyazato A, Xiao G, Hatta M, Inden K, Aoyagi T, Shiratori K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Suzuki K, Fujita J, Kaku M, Kawakami K.
Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway.
J Immunol. 2008 Mar 15;180(6):4067-74.

16. Nishimura J, Saiga H, Sato S, Okuyama M, Kayama H, Kuwata H, Matsumoto S, Nishida T, Sawa Y, Akira S , Yoshikai Y, Yamamoto M, Takeda K.
Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor.
J Immunol. 2008 Mar 15;180(6):4032-9.

15. Kagan JC, Su T, Horng T, Chow A, Akira S , Medzhitov R.
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.
Nat Immunol. 2008 Feb 24; [Epub ahead of print]

14. Takeuchi O, Akira S.
MDA5/RIG-I and virus recognition.
Curr Opin Immunol. 2008 Feb 11;20(1):17-22 [Epub ahead of print]

13. Kumagai Y, Takeuchi O, Akira S.
TLR9 as a key receptor for the recognition of DNA.
Adv Drug Deliv Rev. 2008 Jan 3; [Epub ahead of print]

12. Ishii KJ*, Kawagoe T*, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S .
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Nature. 2008 Feb 7;451(7179):725-729. (*contributed equally)

11. Zhang B, Ramesh G, Uematsu S, Akira S , Reeves WB.
TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity.
J Am Soc Nephrol. 2008 Feb 6; [Epub ahead of print]

10. Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S , Takeda K, Yasutomo K, Torii M, Himeno K.
Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells.
J Immunol. 2008 Feb 15;180(4):2496-503.

9. Nakano Y, Kuroda E, Kito T, Uematsu S, Akira S , Yokota A, Nishizawa S, Yamashita U.
Induction of prostaglandin E(2) synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors.
J Neurosurg. 2008 Feb;108(2):311-319.

8. Bhattacharjee RN, Park KS, Chen X, Iida T, Honda T, Takeuchi O, Akira S .
Translocation of VP1686 Upregulates RhoB and Accelerates Phagocytic Activity of Macrophage Through Actin Remodeling.
J Microbiol Biotechnol. 2008 Jan;18(1):171-5.

7. Foster GL, Barr TA, Grant AJ, McKinley TJ, Bryant CE, Macdonald A, Gray D, Yamamoto M, Akira S, Maskell DJ, Mastroeni P.
Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88.
Immunology. 2008 Jan 24; [Epub ahead of print]

6. Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN.
Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity.
J Immunol. 2008 Feb 1;180(3):1609-18.

5. Vijay-Kumar M, Aitken JD, Kumar A, Neish AS, Uematsu S, Akira S , Gewirtz AT.
TLR5KO mice have dysregulated intestinal gene expression and non-specific resistance to Salmonella-induced typhoid-like disease.
Infect Immun. 2008 Jan 14; [Epub ahead of print]

4. Escors D, Lopes L, Lin R, Hiscott J, Akira S , Davis RJ, Collins MK.
Targeting dendritic cell signalling to regulate the response to immunisation.
Blood. 2008 Jan 7; [Epub ahead of print]

3. Kumar H*, Koyama S*, Ishii KJ, Kawai T, Akira S .
Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses.
J Immunol. 2008 Jan 15;180(2):683-7. (*contributed equally)

2. Swann JB, Vesely MD, Silva A, Sharkey J, Akira S , Schreiber RD, Smyth MJ.
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.
Proc Natl Acad Sci U S A. 2008 Jan 4; [Epub ahead of print]

1. Uematsu S, Akira S.
Toll-Like Receptors (TLRs) and Their Ligands.
Handb Exp Pharmacol. 2008;183:1-20. 69.