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Associate ProfessorYoshiko Murakami

Research Projects

I have an additional appointment in the Department of Immunoregulation, where I serve as the leader of the PNH group. This group is performing the following studies (see details on the Department page):

  1. Investigation of the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH), an acquired glycosylphosphatidylinositol (GPI) deficiency.
  2. Investigation of the pathogenesis of inherited GPI deficiency.
  3. Investigation of the functional significance of GPI-anchored proteins by using the Pgap3 KO mouse in which GPI-anchored proteins fail to localize within the raft due to defective GPI anchor remodeling.

Major publications

  1. Sena CB, Fukuda T, Miyanagi K, Matsumoto S, Kobayashi K, Murakami Y, Maeda Y, Kinoshita T, Morita YS. Controlled expression of branch-forming mannosyltransferase is critical for mycobacterial lipoarabinomannan biosynthesis. J Biol Chem. 2010 Apr 30;285(18):13326-36.
  2. Kanzawa N, Maeda Y, Ogiso H, Murakami Y, Taguchi R, Kinoshita T. Peroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17711-6.
  3. Almeida AM*, Murakami Y*, Baker A, Maeda Y, Roberts IA, Kinoshita T, Layton DM, Karadimitris A. Targeted therapy for inherited GPI deficiency. N Engl J Med. 2007 Apr 19;356(16):1641-7(* equally contributed).
  4. Almeida AM*, Murakami Y*, Layton M, Hillmen P, Sellick G, Maeda Y, Richards S, Patterson S, Kotsianidis I, Mollica L, Crawford D, Baker A, Ferguson M, Roberts I, Houlston R, Kinoshita T, Karadimitris A. Hypomorphic promoter mutation in the mannosyltransferase-encoding PIG-M gene causes inherited glycosylphosphatidylinositol deficiency. Nat Med. 2006 Jul;12(7):846-51.(* equally contributed).
  5. Inoue N, Izui-Sarumaru T, Murakami Y, Endo Y, Nishimura J, Kurokawa K, Kuwayama M, Shime H, Machii T, Kanakura Y, Meyers G, Wittwer C, Chen Z, Babcock W, Frei-Lahr D, Parker C, Kinoshita T. Molecular basis of clonal expansion of hematopoiesis in two patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood. 2006 Dec 15;108(13):4232-6.

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