Research Collaboration Center on Emerging and Re-emerging Infections

Section of Viral Infections

Research Group / Research Projects / Major publications /

Research Group

SA ProfessorNaokazu Takeda
SA ProfessorMasanori Kameoka
Professor (SUP)Kazuyoshi Ikuta
Professor (SUP)Tatsuo Shioda

Research Projects

Intestinal infectious diseases (enteroviral infections): It has recently become difficult to isolate viruses from patients with hand, foot and mouth diseases, and it has been suggested that enteroviruses other than Enterovirus 71 and Coxsackie virus 16 may be involved. To grasp the prevalence of these viruses in Thailand, molecular epideomiological studies are currently underway.

Blood-borne infectious diseases (HIV diseases/AIDS): We are performing basic studies that examine the virological and immunological characteristics of the HIV-1 CRF01_AE strains that are prevalent in Southeast Asia, including Thailand. In addition, the mechanism by which HIV acquires viral drug resistance to anti-retroviral drugs is being studied.

Mosquito-borne infectious diseases (dengue fever): We are constructing infectious molecularly cloned viruses to identify the viral genes that are involved in viral pathogenesis.

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Major publications

  1. Utachee P, Nakamura S, Isarangkura-na-ayuthaya P, Tokunaga K, Sawanpanyalert P, Ikuta K, Auwanit W, Kameoka M. Two N-linked glycosylation sites in V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for CD4 binding domain. J Virol. 2010;84:4311-20.
  2. Pongsuwannna Y, Guntapong R, Tacharoenmuang R, Prapanpoj M, Kameoka M, Taniguchi K. A long-term survey on the distribution of the human G type rotavirus in Thailand. J Med Virol. 2010;82:157-63.
  3. Bai GR, Chittaganpitch M, Kanai Y, Li YG, Auwanit W, Ikuta K, Sawanpanyalert P. Amantadine- and oseltamivir-resistant variants of influenza A viruses in Thailand. Biochem Biophys Res Commun. 2009;390:897-901.
  4. Jinnopat P, Isarangkura-na-ayuthaya P, Utachee P, Kitagawa Y, de Silva UC, Siripanyaphinyo U, Kameoka Y, Tokunaga K, Sawanpanyalert P, Ikuta K, Auwanit W, Kameoka M. Impact of Amino Acid Variations in Gag and Protease of Human Immunodeficiency Virus Type 1 CRF01_AE strains on Drug Susceptibility of Virus to Protease Inhibitors. J Acquir Immune Defic Syndr 2009;52:320-8.
  5. Auwanit W, Isarangkura-na-ayuthaya P, kasornpikul D, Ikuta K, Sawanpanyalert P, Kameoka M. Detection of drug resistance-associated and background mutations in human immunodeficiency virus type 1 CRF01_AE protease and reverse transcriptase derived from drug treatment-naive patients residing in central Thailand. AIDS Res Hum Retroviruses 2009;25:625-31.
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