Research Collaboration Center on Emerging and Re-emerging Infections

Section of Bacterial Infections

Research Group / Research Projects / Major publications /

Research Group

SA ProfessorShigeyuki Hamada
SA Associate ProfessorYumi Kumagai
SA Assistant ProfessorKazuhisa Okada

Research Projects

The Section of Bacterial Infections pays special attention to emerging and reemerging bacterial diseases that are prevalent or are broken out in Asian countries. We study the molecular epidemiology of enteric or systemic bacterial infections. Moreover, in collaboration with the National Institute of Health, Department of Medical Sciences, Ministry of Public Health of Thailand, we develop detection and identification techniques for the diagnosis of bacterial diseases.

It has been reported that pneumonia, tuberculosis, and acute diarrheal diseases are associated with high morbidity and mortality rates in Thailand. Consequently, in the Program of Promotion of Research Network for Emerging and Reemerging Infectious Diseases during the 2010-2014 fiscal years, we prioritize research on enteric infectious diseases in Thailand that are caused by Vibirio cholerae and diarrheagenic E. coli.

In addition, Streptococcus suis, which is generally pathogenic and frequently isolated from diseased pigs, has been found to cause several systemic (zoonotic) infectious diseases in humans, namely meningitis, infective endocarditis, and toxic shock-like syndrome. This has mainly been observed in Asian countries, including Northern Thailand. We survey this emerging zoonotic infection closely, and elucidate the molecular pathogenesis of S. suis infections.

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Cholera surveillance in the border of Thailand and Myanmar


Major publications

  1. Okada K, Chantaroj S, Roobthaisong A, Hamada S, Sawanpanyalert P. A Cholera Outbreak of the Vibrio cholerae O1 El Tor Variant Carrying Classical CtxB in Northeastern Thailand in 2007. Am J Trop Med Hyg, 2010. May; 82(5):875-8.
  2. Puiprom O, Chantaroj S, Gangnonngiw W, Okada K, Honda T, Taniguchi T, Sawanpanyalert P. Identification of colonization factors of enterotoxigenic Escherichia coli with PCR-based technique. Epidemiol Infect 2010.Apr;138(4):519-24.
  3. Okada K, Chantaroj S, Taniguchi T, Suzuki Y, Roobthaisong A, Puiprom O, Honda T, Sawanpanyalert P. A rapid, simple, and sensitive loop-mediated isothermal amplification method to detect toxigenic Vibrio cholerae in rectal swab samples. Diagn Microbiol Infect Dis 2010. Feb;66(2):135-9.
  4. Maruyama F, Kobata M, Kurokawa K, Nishida K, Sakurai A, Nakano K, Nomura R, Kawabata S, Ooshima T, Nakai K, Hattori M, Hamada S, Nakagawa I. Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content. BMC Genomics 2009. Aug 5;10:358.
  5. Kasai S, Okada K, Hoshino A, Iida T, Honda T. Lateral transfer of the lux gene cluster. J Biochem 2007. Feb;141(2):231-7.
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