Mahidol-Osaka Center for Infectious Diseases

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Research Group

Head,Professor (SUP)Tatsuo Shioda

Research Projects

The MOCID interest focuses on several tropical infectious diseases that are of human health importance in Thailand, especially mosquito-borne viral infectious diseases such as dengue fever/dengue hemorrhagic fever and chikungunya fever. We focus on the development of rapid diagnosis kits for the viral diseases, and the studies of the prevalence of the viral infections in human and mosquitoes and the pathogenesis of the viruses. We would like to raise young scientists’ interest and research skills on the infectious diseases through our collaborating with Mahidol University by using clinical samples.

Our main research project
1) Epidemiology of mosquito-borne virus infections in human and mosquitoes in Thailand.
2) Generation and characterization of human and mouse monoclonal antibodies against dengue virus and chikungunya virus.
3) Development of diagnosis kits for the viral diseases.

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Major publications

  1. Chaichana P, Okabayashi T, Puiprom O, Sasayama M, Sasaki T, Yamashita A, Ramasoota P, Kurosu T, Ikuta K.Low levels of antibody-dependent enhancement in vitro using viruses and plasma from dengue patients. PLoS One. 2014 Mar 18;9(3):e92173.
  2. Pitaksajjakul P, Benjathummarak S, Pipattanaboon C, Wongwit W, Okabayashi T, Kuhara M, Misaki R, Fujiyama K, Ramasoota P. Antibody germline characterization of cross-neutralizing human IgGs against 4 serotypes of dengue virus. Pitaksajjakul P, Lekcharoensuk P, Uparagarin N, Barbas C, Ibrahim MS, Ikuta K, and Ramasoota P. Biochem Biophys Res Commun. 2014 Mar 14.
  3. Ngaosuwankul N, Thippornchai N, Yamashita A, Vargas RE, Tunyong W, Mahakunkijchareon Y, Ikuta K, Singhasivanon P, Okabayashi T, Leaungwutiwong P. Detection and characterization of enteric viruses in flood water from the 2011 thai flood. Jpn J Infect Dis. 2013;66(5):398-403
  4. Puiprom O, Morales Vargas RE, Potiwat R, Chaichana P, Ikuta K, Ramasoota P,Okabayashi T. Characterization of chikungunya virus infection of a human keratinocyte cell line: role of mosquito salivary gland protein in suppressing the host immune response. Infect Genet Evol. 2013 Jul;17:210-5.
  5. Sasaki T, Setthapramote C, Kurosu T, Nishimura M, Asai A, Omokoko MD, Pipattanaboon C, Pitaksajjakul P, Limkittikul K, Subchareon A, Chaichana P, Okabayashi T, Hirai I, Leaungwutiwong P, Misaki R, Fujiyama K, Ono K, Okuno Y, Ramasoota P, Ikuta K. Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection. Antiviral Res. 2013 Jun;98(3):423-31.

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