Vaccine Dynamics Project, BIKEN Innovative Vaccine Research Alliance Laboratories

Staff:

Specially Appointed Associate Professor

Taiki Aoshi, M.D., Ph.D.

Specially Appointed Researcher

Yoshihiko Tanimoto

Meng Jie

Guirong Kanai

Yasunari Haseda

Visiting Researcher

Mie Okutani

Subjects:

1. Identification of new T cell epitopes for diseases including infection, autoimmunity, and cancer.
2. Understanding of antigen presenting cells/CD4T/CD8T cell interactions and their effects on T cell response induction.
3. Development of clinically applicable new A/D type CpG ODNs.

Papers published in 2017

1. Quantifying the relative immune cell activation from whole tissue/organ-derived differentially expressed gene data.

   Edward Wijaya, Yoshinobu Igarashi, Noriyuki Nakatsu, Yasunari Haseda, Joel Billaud, Yi-An Chen, Kenji Mizuguchi, Hiroshi Yamada, Ken Ishii and Taiki Aoshi

   Sci Rep, 7 (1), 12847, 2017.
2. Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus.

   Akane Urakami, Atsuko Sakurai, Momoko Ishikawa, Moh Lan Yap, Yevel Flores-Garcia, Yasunari Haseda, Taiki Aoshi, Fidel P Zavala, Michael G Rossmann, Sachiko Kuno, Ryuji Ueno and Wataru Akahata

   Clin Vaccine Immunol, 24 (7), e00090- 17, 2017.
3. Modes of Action for Mucosal Vaccine Adjuvants.

   Taiki Aoshi

   Viral Immunol, 30 (6), 463-470, 2017.
4. Isoflurane is a suitable alternative to ether for anesthetizing rats prior to euthanasia for gene expression analysis.

   Noriyuki Nakatsu, Yoshinobu Igarashi, Taiki Aoshi, Isao Hamaguchi, Masumichi Saito, Takuo Mizukami, Haruka Momose, Ken J Ishii and Hiroshi Yamada

   J Toxicol Sci, 42 (4), 491-497, 2017.
5. Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines.

   Masayuki Hayashi, Taiki Aoshi, Yasunari Haseda, Kouji Kobiyama, Edward Wijaya, Noriyuki Nakatsu, Yoshinobu Igarashi, Daron M Standley, Hiroshi Yamada, Yoshikazu Honda-Okubo, Hiromitsu Hara, Takashi Saito, Toshiyuki Takai, Cevayir Coban, Nikolai Petrovsky and Ken J Ishii

   EBioMedicine, 15, 127-136, 2017.
6. A novel vaccinological evaluation of intranasal vaccine and adjuvant safety for preclinical tests.

   Eita Sasaki, Madoka Kuramitsu, Haruka Momose, Kouji Kobiyama, Taiki Aoshi, Hiroshi Yamada, Ken J Ishii, Takuo Mizukami and Isao Hamaguchi

   Vaccine, 35 (5), 821-830, 2017.

Link

Vaccine Dynamics Project, BIKEN Innovative Vaccine Research Alliance Laboratories

Research Institute for Microbial Diseases, Osaka University