Department of Signal Transduction

Staff:

Professor

Nobuyuki Takakura, M.D., Ph.D.

Assistant Professor

Hiroyasu Kidoya, Ph.D.

Hisamichi Naito, M.D., Ph.D.

Specially Appointed Researcher

Weizhen Jia, Ph.D.

Fumitaka Muramatsu

Graduate Student

Daisuke Eino

Miku Kitta

Yumiko Hayashi

Youhei Tsukada

Tomohiro Iba

Hu Liuying

Hsieh Han-yun

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Papers published in 2017

1. Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency.

   Mari Yoshida, Yukichi Ishioka, Takamasa Ozawa, Hirohisa Okuyama, Motofumi Iguchi, Takeshi Ota, Takaomi Ito, Morio Nagira, Atsushi Morita, Hidekazu Tanaka, Hisamichi Naito, Hiroyasu Kidoya and Nobuyuki Takakura

   Sci Rep, 7 (1), 11137, 2017.
2. Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy.

   Ryu Kanzaki, Hisamichi Naito, Kazuyoshi Kise, Kazuhiro Takara, Daisuke Eino, Masato Minami, Yasushi Shintani, Soichiro Funaki, Tomohiro Kawamura, Toru Kimura, Meinoshin Okumura and Nobuyuki Takakura

   Sci Rep, 7 (1), 10613, 2017.
3. Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact.

   Kazuhiro Takara, Daisuke Eino, Koji Ando, Daisuke Yasuda, Hisamichi Naito, Yohei Tsukada, Tomohiro Iba, Taku Wakabayashi, Fumitaka Muramatsu, Hiroyasu Kidoya, Shigetomo Fukuhara, Naoki Mochizuki, Satoshi Ishii, Haruhiko Kishima and Nobuyuki Takakura

   Cell Rep, 20 (9), 2072-2086, 2017.
4. A New Player in the Biorefineries Field: Phasin PhaP Enhances Tolerance to Solvents and Boosts Ethanol and 1,3-Propanediol Synthesis in Escherichia coli.

   Mariela P Mezzina, Daniela S Álvarez, Diego E Egoburo, Rocío Díaz Peña, Pablo I Nikel and M Julia Pettinari

   Appl Environ Microbiol, 83 (14), , 2017.
5. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.

   Shuntaro Ogura, Kaori Kurata, Yuki Hattori, Hiroshi Takase, Toshina Ishiguro-Oonuma, Yoonha Hwang, Soyeon Ahn, Inwon Park, Wataru Ikeda, Sentaro Kusuhara, Yoko Fukushima, Hiromi Nara, Hideto Sakai, Takashi Fujiwara, Jun Matsushita, Masatsugu Ema, Masanori Hirashima, Takashi Minami, Masabumi Shibuya, Nobuyuki Takakura, Pilhan Kim, Takaki Miyata, Yuichiro Ogura and Akiyoshi Uemura

   JCI Insight, 2 (3), e90905, 2017.
6. Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer.

   Miku Torigata, Daishi Yamakawa and Nobuyuki Takakura

   Cancer Med, 6 (6), 1378-1388, 2017.
7. Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice.

   Jun Matsushita, Shigenori Inagaki, Tomomi Nishie, Tomoki Sakasai, Junko Tanaka, Chisato Watanabe, Ken-Ichi Mizutani, Yoshihiro Miwa, Ken Matsumoto, Kazuhiro Takara, Hisamichi Naito, Hiroyasu Kidoya, Nobuyuki Takakura, Takeharu Nagai, Satoru Takahashi and Masatsugu Ema

   Sci Rep, 7, 46597, 2017.
8. Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin.

   Fumitaka Muramatsu, Hiroyasu Kidoya, Hisamichi Naito, Yumiko Hayashi, Tomohiro Iba and Nobuyuki Takakura

   J Biochem, 162 (1), 55-62, 2017.

Link

Department of Signal Transduction

Research Institute for Microbial Diseases, Osaka University