Department of Molecular Virology

Staff:

Professor

Yoshiharu Matsuura, D.V.M., Ph.D.

Associate Professor

Yusuke Maeda, M.D., Ph.D.

Toru Okamoto, Ph.D.

Takasuke Fukuhara, M.D., Ph.D.

Specially Appointed Assistant Professor

Chikako Ono, Ph.D.

JSPS Postdoctoral Fellowship

Tomokazu Tamura, D.V.M., Ph.D.

Graduate Student

Tatsuya Suzuki

Hiroyuki Mori

Shinnji Kusakabe

Asuka Sato

Makoto Tokunaga

Kentaro Uemura

Junki Hirano

Yuzy Fauzyah

Shinya Yamada

Research Student

Ryoichi Shima

Subjects:

1. Studies on hepatitis viruses.
2. Studies on flaviviruses.
3. Development of viral vectors.

Papers published in 2017

1. Characterization of SPP inhibitors suppressing propagation of HCV and protozoa.

   Junki Hirano, Toru Okamoto, Yukari Sugiyama, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Takasuke Fukuhara, Miwa Sasai, Takahiro Tougan, Yasue Matsunaga, Kazuo Yamashita, Yusuke Sakai, Masahiro Yamamoto, Toshihiro Horii, Daron M Standley, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike and Yoshiharu Matsuura

   Proc Natl Acad Sci U S A, 114 (50), E10782-E10791, 2017.
2. Cell surface N-glycan alteration in HepAD38 cell lines expressing Hepatitis B virus.

   Surya Agung Priyambada, Ryo Misaki, Toru Okamoto, Yuta Okamoto, Takao Ohashi, Keiji Ueda, Yoshiharu Matsuura and Kazuhito Fujiyama

   Virus Res, 238, 101-109, 2017.
3. The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.

   Michihiro Takahama, Mitsunori Fukuda, Norihiko Ohbayashi, Tatsuya Kozaki, Takuma Misawa, Toru Okamoto, Yoshiharu Matsuura, Shizuo Akira and Tatsuya Saitoh

   Cell Rep, 20 (12), 2944-2954, 2017.
4. Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.

   Shinji Tagami, Kanta Yanagida, Takashi S Kodama, Mako Takami, Naoki Mizuta, Hiroshi Oyama, Kouhei Nishitomi, Yu-Wen Chiu, Toru Okamoto, Takeshi Ikeuchi, Gaku Sakaguchi, Takashi Kudo, Yoshiharu Matsuura, Akio Fukumori, Masatoshi Takeda, Yasuo Ihara and Masayasu Okochi

   Cell Rep, 21 (1), 259-273, 2017.
5. Regulation of Apoptosis during Flavivirus Infection.

   Toru Okamoto, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata and Yoshiharu Matsuura

   Viruses, 9 (9), , 2017.
6. Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation.

   Masahiko Ito, Suofeng Sun, Takasuke Fukuhara, Ryosuke Suzuki, Miho Tamai, Toyohiko Yamauchi, Kenji Nakashima, Yoh-Ichi Tagawa, Shigetoshi Okazaki, Yoshiharu Matsuura, Takaji Wakita and Tetsuro Suzuki

   Oncotarget, 8 (33), 53899-53915, 2017.
7. Two-amino acids change in the nsp4 of SARS coronavirus abolishes viral replication.

   Yusuke Sakai, Kengo Kawachi, Yutaka Terada, Hiroko Omori, Yoshiharu Matsuura and Wataru Kamitani

   Virology, 510, 165-174, 2017.
8. MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA.

   Yutaka Terada, Kengo Kawachi, Yoshiharu Matsuura and Wataru Kamitani

   Virology, 511, 95-105, 2017.
9. Reverse genetics system demonstrates that rotavirus non-structural protein NSP6 is not essential for viral replication in cell culture.

   Satoshi Komoto, Yuta Kanai, Saori Fukuda, Masanori Kugita, Takahiro Kawagishi, Naoto Ito, Makoto Sugiyama, Yoshiharu Matsuura, Takeshi Kobayashi and Koki Taniguchi

   J Virol, 91 (21), e00695-00617, 2017.
10. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.

    Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira and Tatsuya Saitoh

    Proc Natl Acad Sci U S A, 114 (10), 2681-2686, 2017.
11. Characterization of miR-122-independent propagation of HCV.

    Chikako Ono, Takasuke Fukuhara, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Satomi Yamamoto, Tomokazu Tamura, Hiroyuki Mori, Asuka Sato, Kentaro Uemura, Yuzy Fauzyah, Takeshi Kurihara, Takahiro Suda, Akira Nishio, Su Su Hmwe, Toru Okamoto, Tomohide Tatsumi, Tetsuo Takehara, Kazuaki Chayama, Takaji Wakita, Kazuhiko Koike and Yoshiharu Matsuura

    PLoS Pathog, 13 (5), e1006374, 2017.
12. Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9.

    Takeshi Kurihara, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masaya Sugiyama, Daisuke Motooka, Shota Nakamura, Masahito Ikawa, Masashi Mizokami, Yoshihiko Maehara and Yoshiharu Matsuura

    Sci Rep, 7 (1), 6122, 2017.
13. Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae.

    Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda and Yoshiharu Matsuura

    PLoS Pathog, 13 (6), e1006475, 2017.
14. Quasispecies of Hepatitis C Virus Participate in Cell-Specific Infectivity.

    Takasuke Fukuhara, Satomi Yamamoto, Chikako Ono, Shota Nakamura, Daisuke Motooka, Hiroyuki Mori, Takeshi Kurihara, Asuka Sato, Tomokazu Tamura, Takashi Motomura, Toru Okamoto, Michio Imamura, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Yoshihiko Maehara, Kazuaki Chayama and Yoshiharu Matsuura

    Sci Rep, 7, 45228, 2017.
15. Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015.

    Bazarragchaa Enkhbold, Munkhduuren Shatar, Shiho Wakamori, Tomokazu Tamura, Takahiro Hiono, Keita Matsuno, Masatoshi Okamatsu, Takashi Umemura, Batchuluun Damdinjav and Yoshihiro Sakoda

    Virus Genes, 53 (3), 418-425, 2017.
16. Entirely plasmid-based reverse genetics system for rotaviruses.

    Yuta Kanai, Satoshi Komoto, Takahiro Kawagishi, Ryotaro Nouda, Naoko Nagasawa, Misa Onishi, Yoshiharu Matsuura, Koki Taniguchi and Takeshi Kobayashi

    Proc Natl Acad Sci U S A, 114 (9), 2349-2354, 2017.
17. CD14(+) monocyte-derived galectin-9 induces natural killer cell cytotoxicity in chronic hepatitis C.

    Akira Nishio, Tomohide Tatsumi, Takatoshi Nawa, Takahiro Suda, Teppei Yoshioka, Yoshiki Onishi, Satoshi Aono, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Daisuke Okuzaki, Takasuke Fukuhara, Yoshiharu Matsuura, Naoki Hiramatsu and Tetsuo Takehara

    Hepatology, 65 (1), 18-31, 2017.

Link

Department of Molecular Virology

Research Institute for Microbial Diseases, Osaka University