Department of Molecular Genetics

Staff:

Professor

Hiroshi Nojima, Ph.D.

Associate Professor

Norikazu Yabuta, Ph.D.

Assistant Professor(SUP)

Daisuke Okuzaki, Ph.D.

Specially Appointed Researcher

Yoko Naito,Ph.D.

Researcher

Kyoko Nakajima

Research Collaborator

Daisaku Miura, Ph.D.

Graduate Student

Kaori Ota

Chie Ota

Yorika Kato

Subjects:

1. Molecular mechanisms regulating the cell cycle (checkpoint) in mammalian cells.
2. Molecular mechanisms modulating the malignancy of cancer cells.
3. Application of a new technique (Leuko Catch) to RNA diagnosis.

Papers published in 2017

• Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association with Cell Shape and Cytoskeletal Modifications.

  Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri and Akihiko Ito

  Front Physiol, 8, 997, 2017.
• ELAS1 induces apoptotic death in adenocarcinoma DU145 and squamous-cell carcinoma SAS cancer cells, but not in normal KD cells.

  Toshihiro Uchihashi, Kaori Ota, Yusuke Yabuno, Shouichi Ohno, Kohshiro Fukushima, Yoko Naito, Mikihiko Kogo, Norikazu Yabuta and Hiroshi Nojima

  Oncotarget, 8 (49), 85868-85882, 2017.
• FCN1 (M-ficolin), which directly associates with immunoglobulin G1, is a molecular target of intravenous immunoglobulin therapy for Kawasaki disease.

  Daisuke Okuzaki, Kaori Ota, Shin-Ichi Takatsuki, Yukari Akiyoshi, Kazuyuki Naoi, Norikazu Yabuta, Tsutomu Saji and Hiroshi Nojima

  Sci Rep, 7 (1), 11334, 2017.
• Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function.

  Takashi Hosokawa, Tetsuya Kimura, Shigeyuki Nada, Tatsusada Okuno, Daisuke Ito, Sujin Kang, Satoshi Nojima, Kazuya Yamashita, Takeshi Nakatani, Yoshitomo Hayama, Yasuhiro Kato, Yuhei Kinehara, Masayuki Nishide, Norihisa Mikami, Syohei Koyama, Hyota Takamatsu, Daisuke Okuzaki, Naganari Ohkura, Shimon Sakaguchi, Masato Okada and Atsushi Kumanogoh

  J Immunol, 199 (6), 2008-2019, 2017.
• GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase.

  Kohshiro Fukushima, Mian Wang, Yoko Naito, Toshihiro Uchihashi, Yorika Kato, Satomi Mukai, Norikazu Yabuta and Hiroshi Nojima

  Cell Cycle, 16 (5), 415-427, 2017.
• CD14(+) monocyte-derived galectin-9 induces natural killer cell cytotoxicity in chronic hepatitis C.

  Akira Nishio, Tomohide Tatsumi, Takatoshi Nawa, Takahiro Suda, Teppei Yoshioka, Yoshiki Onishi, Satoshi Aono, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Daisuke Okuzaki, Takasuke Fukuhara, Yoshiharu Matsuura, Naoki Hiramatsu and Tetsuo Takehara

  Hepatology, 65 (1), 18-31, 2017.

Link

Research Institute for Microbial Diseases, Osaka University