Department of Infection Metagenomics

Staff:

Professor (SUP)

Toshihiro Horii, Ph.D.

Tetsuya Iida, Ph.D.

Associate Professor (SUP)

Naohisa Goto, Ph. D.

Specially Appointed Associate Professor (SUP)

Shota Nakamura, Ph. D.

Specially Appointed Assistant Professor(SUP)

Daisuke Motooka, Ph. D.

Specially Appointed Researcher

Yuki Matsumoto, Ph. D.

Subjects:

1. Development of metagenomic diagnosis system for pathogen identification.
2. Studies on gut microbiota.
3. Application of next-generation sequencing.

Papers published in 2017

1. Highly sensitive detection of ESR1 mutations in cell-free DNA from patients with metastatic breast cancer using molecular barcode sequencing.

   Nanae Masunaga, Naofumi Kagara, Daisuke Motooka, Shota Nakamura, Tomohiro Miyake, Tomonori Tanei, Yasuto Naoi, Masafumi Shimoda, Kenzo Shimazu, Seung Jin Kim and Shinzaburo Noguchi

   Breast Cancer Res Treat, 167 (1), 49-58, 2017.
2. Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis and Bacterial Translocation in a Murine Model of Sepsis.

   Mitsunori Ikeda, Kentaro Shimizu, Hiroshi Ogura, Takashi Kurakawa, Eiji Umemoto, Daisuke Motooka, Shota Nakamura, Naotsugu Ichimaru, Kiyoshi Takeda, Shiro Takahara, Shin-Ichi Hirano and Takeshi Shimazu

   Shock, , , 2017.
3. N-Glycan-dependent protein folding and endoplasmic reticulum retention regulate GPI-anchor processing.

   Yi-Shi Liu, Xin-Yu Guo, Tetsuya Hirata, Yao Rong, Daisuke Motooka, Toshihiko Kitajima, Yoshiko Murakami, Xiao-Dong Gao, Shota Nakamura, Taroh Kinoshita and Morihisa Fujita

   J Cell Biol, 217 (2), 585-599, 2017.
4. Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.

   Shuhei Sakakibara, Takao Arimori, Kazuo Yamashita, Hideyuki Jinzai, Daisuke Motooka, Shota Nakamura, Songling Li, Kazuya Takeda, Jun Katayama, Marwa Ali El Hussien, Masashi Narazaki, Toshio Tanaka, Daron M Standley, Junichi Takagi and Hitoshi Kikutani

   Sci Rep, 7 (1), 16428, 2017.
5. Mutation accumulation under UV radiation in Escherichia coli.

   Atsushi Shibai, Yusuke Takahashi, Yuka Ishizawa, Daisuke Motooka, Shota Nakamura, Bei-Wen Ying and Saburo Tsuru

   Sci Rep, 7 (1), 14531, 2017.
6. Genetic characterization of blaNDM-harboring plasmids in carbapenem-resistant Escherichia coli from Myanmar.

   Yo Sugawara, Yukihiro Akeda, Noriko Sakamoto, Dan Takeuchi, Daisuke Motooka, Shota Nakamura, Hideharu Hagiya, Norihisa Yamamoto, Isao Nishi, Hisao Yoshida, Kazuhisa Okada, Khwar Nyo Zin, Mya Mya Aye, Kazunori Tomono and Shigeyuki Hamada

   PLoS One, 12 (9), e0184720, 2017.
7. Whole-Genome Sequence of

   Hidenori Yoshizawa, Daisuke Motooka, Ryuichi Katada, Yuki Matsumoto, Shota Nakamura, Eiichi Morii, Tetsuya Iida and Hiroshi Matsumoto

   Genome Announc, 5 (35), e00878- 17, 2017.
8. The cell envelope-associated phospholipid-binding protein LmeA is required for mannan polymerization in mycobacteria.

   Kathryn C Rahlwes, Stephanie A Ha, Daisuke Motooka, Jacob A Mayfield, Lisa R Baumoel, Justin N Strickland, Ana P Torres-Ocampo, Shota Nakamura and Yasu S Morita

   J Biol Chem, 292 (42), 17407-17417, 2017.
9. Characterization of miR-122-independent propagation of HCV.

   Chikako Ono, Takasuke Fukuhara, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Satomi Yamamoto, Tomokazu Tamura, Hiroyuki Mori, Asuka Sato, Kentaro Uemura, Yuzy Fauzyah, Takeshi Kurihara, Takahiro Suda, Akira Nishio, Su Su Hmwe, Toru Okamoto, Tomohide Tatsumi, Tetsuo Takehara, Kazuaki Chayama, Takaji Wakita, Kazuhiko Koike and Yoshiharu Matsuura

   PLoS Pathog, 13 (5), e1006374, 2017.
10. Draft Genome Sequence of Plasmodium gonderi, a Malaria Parasite of African Old World Monkeys.

    Hajime Honma, Satoru Kawai, Daisuke Motooka, Shota Nakamura, Takahiro Tougan, Toshihiro Horii and Nobuko Arisue

    Genome Announc, 5 (28), e00612- 17, 2017.
11. Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9.

    Takeshi Kurihara, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masaya Sugiyama, Daisuke Motooka, Shota Nakamura, Masahito Ikawa, Masashi Mizokami, Yoshihiko Maehara and Yoshiharu Matsuura

    Sci Rep, 7 (1), 6122, 2017.
12. Wilms tumour 1 peptide vaccine as a cure-oriented post-chemotherapy strategy for patients with acute myeloid leukaemia at high risk of relapse.

    Jun Nakata, Yoshiki Nakae, Manabu Kawakami, Soyoko Morimoto, Daisuke Motooka, Naoki Hosen, Fumihiro Fujiki, Hiroko Nakajima, Kana Hasegawa, Sumiyuki Nishida, Akihiro Tsuboi, Yusuke Oji, Yoshihiro Oka, Atsushi Kumanogoh and Haruo Sugiyama

    Br J Haematol, , , 2017.
13. Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection.

    Atsushi Tanaka, Uranan Tumkosit, Shota Nakamura, Daisuke Motooka, Natsuko Kishishita, Thongkoon Priengprom, Areerat Sa-Ngasang, Taroh Kinoshita, Naokazu Takeda and Yusuke Maeda

    J Virol, 91 (13), e00432- 17, 2017.
14. Plasmid dynamics in Vibrio parahaemolyticus strains related to shrimp Acute Hepatopancreatic Necrosis Syndrome (AHPNS).

    Chonchanok Theethakaew, Shota Nakamura, Daisuke Motooka, Shigeaki Matsuda, Toshio Kodama, Kaknokrat Chonsin, Orasa Suthienkul and Tetsuya Iida

    Infect Genet Evol, 51, 211-218, 2017.
15. Phenotype-genotype correlations of PIGO deficiency with variable phenotypes from infantile lethality to mild learning difficulties.

    Junpei Tanigawa, Haruka Mimatsu, Seiji Mizuno, Nobuhiko Okamoto, Daisuke Fukushi, Koji Tominaga, Hiroyuki Kidokoro, Yukako Muramatsu, Eriko Nishi, Shota Nakamura, Daisuke Motooka, Noriko Nomura, Kiyoshi Hayasaka, Tetsuya Niihori, Yoko Aoki, Shin Nabatame, Masahiro Hayakawa, Jun Natsume, Keiichi Ozono, Taroh Kinoshita, Nobuaki Wakamatsu and Yoshiko Murakami

    Hum Mutat, 38 (7), 805-815, 2017.
16. Quasispecies of Hepatitis C Virus Participate in Cell-Specific Infectivity.

    Takasuke Fukuhara, Satomi Yamamoto, Chikako Ono, Shota Nakamura, Daisuke Motooka, Hiroyuki Mori, Takeshi Kurihara, Asuka Sato, Tomokazu Tamura, Takashi Motomura, Toru Okamoto, Michio Imamura, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Yoshihiko Maehara, Kazuaki Chayama and Yoshiharu Matsuura

    Sci Rep, 7, 45228, 2017.
17. Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.

    Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu and Shimon Sakaguchi

    Nat Immunol, 18 (4), 474, 2017.
18. Fungal ITS1 Deep-Sequencing Strategies to Reconstruct the Composition of a 26-Species Community and Evaluation of the Gut Mycobiota of Healthy Japanese Individuals.

    Daisuke Motooka, Kosuke Fujimoto, Reiko Tanaka, Takashi Yaguchi, Kazuyoshi Gotoh, Yuichi Maeda, Yoki Furuta, Takashi Kurakawa, Naohisa Goto, Teruo Yasunaga, Masashi Narazaki, Atsushi Kumanogoh, Toshihiro Horii, Tetsuya Iida, Kiyoshi Takeda and Shota Nakamura

    Front Microbiol, 8, 238, 2017.
19. The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit.

    Daijiro Nabeya, Takeshi Kinjo, Gretchen Lynn Parrott, Ayako Uehara, Daisuke Motooka, Shota Nakamura, Saifun Nahar, Sawako Nakachi, Masashi Nakamatsu, Sakuko Maeshiro, Shusaku Haranaga, Masao Tateyama, Takeaki Tomoyose, Hiroaki Masuzaki, Toshihiro Horii and Jiro Fujita

    J Med Virol, 89 (8), 1364-1372, 2017.
20. A Cluster of Fatal Tick-borne Encephalitis Virus Infection in Organ Transplant Setting.

    Dariusz Lipowski, Marta Popiel, Karol Perlejewski, Shota Nakamura, Iwona Bukowska-Osko, Ewa Rzadkiewicz, Tomasz Dzieciatkowski, Anna Milecka, Wojciech Wenski, Michal Ciszek, Alicja Debska-Slizien, Ewa Ignacak, Kamila Caraballo Cortes, Agnieszka Pawelczyk, Andrzej Horban, Marek Radkowski and Tomasz Laskus

    J Infect Dis, 215 (6), 896-901, 2017.
21. Postnatal changes in the relative abundance of intestinal Lactobacillus spp. in newborn calves.

    Tadashi Takino, Yuko Kato-Mori, Daisuke Motooka, Shota Nakamura, Tetsuya Iida and Katsuro Hagiwara

    J Vet Med Sci, 79 (3), 452-455, 2017.
22. Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.

    Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu and Shimon Sakaguchi

    Nat Immunol, 18 (2), 173-183, 2017.

Link

Department of Infection Metagenomics

Research Institute for Microbial Diseases, Osaka University