Department of Immunoregulation

Staff:

Professor(SUP)

Taroh Kinoshita, Ph.D.

Associate Professor

Yusuke Maeda, M.D., Ph.D.

Associate Professor(SUP)

Yoshiko Murakami, M.D., Ph.D.

Assistant Professor

Yuko Tashima, Ph.D.

Specially Appointed Assistant Professor

Noriyuki Kanzawa, Ph.D.

Specially Appointed Researcher(SUP)

Chandan Mandal, Ph.D.

Specially Appointed Researcher

Tetsuya Hirata, Ph.D.

Graduate Student

Gun Hee Lee

Yicheng Wang

Research Student

Keiko Kinoshita

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. pH regulation and its biological significance in acidic organelles.

Papers published in 2017

1. Analysis of exome data for 4293 trios suggests GPI-anchor biogenesis defects are a rare cause of developmental disorders.

   Alistair T Pagnamenta, Yoshiko Murakami, John M Taylor, Consuelo Anzilotti, Malcolm F Howard, Venessa Miller, Diana S Johnson, Shereen Tadros, Sahar Mansour, I Karen Temple, Rachel Firth, Elisabeth Rosser, Rachel E Harrison, Bronwen Kerr, Niko Popitsch, Taroh Kinoshita, Jenny C Taylor and Usha Kini et al.

   Eur J Hum Genet, 25 (6), 669-679, 2017.
2. Compound heterozygous mutations in the gene PIGP are associated with early infantile epileptic encephalopathy.

   Devon L Johnstone, Thi-Tuyet-Mai Nguyen, Yoshiko Murakami, Kristin D Kernohan, Martine Tétreault, Claire Goldsmith, Asif Doja, Justin D Wagner, Lijia Huang, Taila Hartley, Anik St-Denis, Françoise le Deist, Jacek Majewski, Dennis E Bulman, Taroh Kinoshita, David A Dyment, Kym M Boycott and Philippe M Campeau et al.

   Hum Mol Genet, 26 (9), 1706-1715, 2017.
3. Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation.

   Susan Realegeno, Andreas S Puschnik, Amrita Kumar, Cynthia Goldsmith, Jillybeth Burgado, Suryaprakash Sambhara, Victoria A Olson, Darin Carroll, Inger Damon, Tetsuya Hirata, Taroh Kinoshita, Jan E Carette and Panayampalli Subbian Satheshkumar

   J Virol, 91 (11), e00011- 17, 2017.
4. Mutations in the phosphatidylinositol glycan C (PIGC) gene are associated with epilepsy and intellectual disability.

   Simon Edvardson, Yoshiko Murakami, Thi Tuyet Mai Nguyen, Maher Shahrour, Anik St-Denis, Avraham Shaag, Nadira Damseh, Françoise Le Deist, Yenan Bryceson, Bassam Abu-Libdeh, Philippe M Campeau, Taroh Kinoshita and Orly Elpeleg

   J Med Genet, 54 (3), 196-201, 2017.
5. A homozygous PIGN missense mutation in Soft-Coated Wheaten Terriers with a canine paroxysmal dyskinesia.

   Ana L Kolicheski, Gary S Johnson, Tendai Mhlanga-Mutangadura, Jeremy F Taylor, Robert D Schnabel, Taroh Kinoshita, Yoshiko Murakami and Dennis P O'Brien

   Neurogenetics, 18 (1), 39-47, 2017.
6. PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis.

   Shinji Ihara, Sohei Nakayama, Yoshiko Murakami, Emiko Suzuki, Masayo Asakawa, Taroh Kinoshita and Hitoshi Sawa

   J Cell Sci, 130 (3), 602-613, 2017.
7. Glycan region of GPI anchored-protein is required for cytocidal oligomerization of an anticancer parasporin-2, Cry46Aa1 protein, from Bacillus thuringiensis strain A1547.

   Yuich Abe, Hiroshi Inoue, Hisashi Ashida, Yusuke Maeda, Taroh Kinoshita and Sakae Kitada

   J Invertebr Pathol, 142, 71-81, 2017.
8. Crystallographic analysis of murine p24γ2 Golgi dynamics domain.

   Masamichi Nagae, Dorothee Liebschner, Yusuke Yamada, Kana Morita-Matsumoto, Naohiro Matsugaki, Toshiya Senda, Morihisa Fujita, Taroh Kinoshita and Yoshiki Yamaguchi

   Proteins, 85 (4), 764-770, 2017.

Link

Department of Immunoregulation

Research Institute for Microbial Diseases, Osaka University