Department of Host Defense

Staff:

Professor(SUP)

Shizuo Akira, M.D., Ph.D.

Associate Professor

Kazuhiko Maeda, Ph.D.

Assistant Professor

Takashi Satoh, Ph.D.

Hiroki Tanaka, Ph.D.

Specially Appointed Assistant Professor(SUP)

Kenta Maruyama, M.D., Ph.D.

Guest Associate Professor

Mikael Martino, Ph.D.

Specially Appointed Researcher

Kanako Kuniyoshi, Ph.D.

Shailendra Kumar Singh, Ph.D.

Joint Research Collaborator

Isao Ebina

Yasuharu Nagahama, Ph.D.

Yuuki Kozakai, Ph.D.

Hiroshi Nabeshima

Kenta J.Yoshida, Ph.D.

Graduate Student

Guoliang Mao

Liang Zhao

Fumihiro Yamane

Hisashi Kanemaru, M.D.

Kiyoharu Fukushima, M.D.

Takanori Matsuki, M.D.

Reiko Mishima

Xin Sun

Mayuko Shimoda

Takahiro Kawasaki, M.D.

Tomohisa Machida, M.D.

Under Graduate Student

Noriyuki Miyamoto

Ryo Takenaka

Taichi Kidani

Soichiro Saeki

Research Student

Thin Sandi Htun

Daiji Ikuta, M.D.

Subjects:

1. Analysis of innate immune response mediated by pattern-recognition receptor family
2. Analysis of disorder-specific macrophage subtype
3. Analysis of mRNA stability systems

Papers published in 2017

1. Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis.

   Carole Henique, Guillaume Bollée, Xavier Loyer, Florian Grahammer, Neeraj Dhaun, Marine Camus, Julien Vernerey, Léa Guyonnet, François Gaillard, Hélène Lazareth, Charlotte Meyer, Imane Bensaada, Luc Legrès, Takashi Satoh, Shizuo Akira, Patrick Bruneval, Stefanie Dimmeler, Alain Tedgui, Alexandre Karras, Eric Thervet, Dominique Nochy, Tobias B Huber, Laurent Mesnard, Olivia Lenoir and Pierre-Louis Tharaux

   Nat Commun, 8 (1), 1829, 2017.
2. T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination.

   Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J Ishii, Shizuo Akira and Hiroyuki Mizuguchi

   Front Immunol, 8, 1456, 2017.
3. The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

   Alessandro Sessa, Ernesto Ciabatti, Daniela Drechsel, Luca Massimino, Gaia Colasante, Serena Giannelli, Takashi Satoh, Shizuo Akira, Francois Guillemot and Vania Broccoli

   Cereb Cortex, 27 (12), 5715, 2017.
4. The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.

   Michihiro Takahama, Mitsunori Fukuda, Norihiko Ohbayashi, Tatsuya Kozaki, Takuma Misawa, Toru Okamoto, Yoshiharu Matsuura, Shizuo Akira and Tatsuya Saitoh

   Cell Rep, 20 (12), 2944-2954, 2017.
5. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.

   Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira and Junying Yuan

   Nat Commun, 8 (1), 359, 2017.
6. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.

   Hisashi Kanemaru, Fumihiro Yamane, Kiyoharu Fukushima, Takanori Matsuki, Takahiro Kawasaki, Isao Ebina, Kanako Kuniyoshi, Hiroki Tanaka, Kenta Maruyama, Kazuhiko Maeda, Takashi Satoh and Shizuo Akira

   Proc Natl Acad Sci U S A, 114 (35), E7331-E7340, 2017.
7. Plasmodium products persist in the bone marrow and promote chronic bone loss.

   Michelle S J Lee, Kenta Maruyama, Yukiko Fujita, Aki Konishi, Patrick M Lelliott, Sawako Itagaki, Toshihiro Horii, Jing-Wen Lin, Shahid M Khan, Etsushi Kuroda, Shizuo Akira, Ken J Ishii and Cevayir Coban

   Sci Immunol, 2 (12), eaam8093, 2017.
8. Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

   Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata, Hironori Bando, Youngae Lee, Tatsuya Saitoh, Shizuo Akira, Akiko Iwasaki, Daron M Standley, Tamotsu Yoshimori and Masahiro Yamamoto

   Nat Immunol, 18 (8), 899-910, 2017.
9. Netrins as prophylactic targets in skeletal diseases: A double-edged sword?

   Kenta Maruyama, Naoki Takemura, Mikaël M Martino, Takeshi Kondo and Shizuo Akira

   Pharmacol Res, 122, 46-52, 2017.
10. An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling.

    Philipp Mertins, Dariusz Przybylski, Nir Yosef, Jana Qiao, Karl Clauser, Raktima Raychowdhury, Thomas M Eisenhaure, Tanja Maritzen, Volker Haucke, Takashi Satoh, Shizuo Akira, Steven A Carr, Aviv Regev, Nir Hacohen and Nicolas Chevrier

    Cell Rep, 19 (13), 2853-2866, 2017.
11. Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.

    Kenta Maruyama, Yasunori Takayama, Takeshi Kondo, Ken-Ichi Ishibashi, Bikash Ranjan Sahoo, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M Martino, Hiroki Tanaka, Naohito Ohno, Yoichiro Iwakura, Naoki Takemura, Makoto Tominaga and Shizuo Akira

    Cell Rep, 19 (13), 2730-2742, 2017.
12. Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.

    Takumi Kawasaki, Kosuke Ito, Haruhiko Miyata, Shizuo Akira and Taro Kawai

    EMBO J, 36 (12), 1707-1718, 2017.
13. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.

    Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira and Tatsuya Saitoh

    Proc Natl Acad Sci U S A, 114 (10), 2681-2686, 2017.
14. Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members.

    Phuong Pham, Samir A Afif, Mayuko Shimoda, Kazuhiko Maeda, Nobuo Sakaguchi, Lars C Pedersen and Myron F Goodman

    DNA Repair (Amst), 54, 8-12, 2017.
15. Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells.

    Kazuhiko Maeda and Shizuo Akira

    Int Immunol, 29 (4), 149-155, 2017.
16. Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity.

    Terumasa Ikeda, Mayuko Shimoda, Diako Ebrahimi, John L VandeBerg, Reuben S Harris, Atsushi Koito and Kazuhiko Maeda

    Sci Rep, 7, 46719, 2017.
17. Integrity of immunoglobulin variable region is supported by GANP during AID-induced somatic hypermutation in germinal center B cells.

    Mohammed Mansour Abbas Eid, Mayuko Shimoda, Shailendra Kumar Singh, Sarah Ameen Almofty, Phuong Pham, Myron F Goodman, Kazuhiko Maeda and Nobuo Sakaguchi

    Int Immunol, 29 (5), 211-220, 2017.
18. DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity.

    Yuichi Kitai, Takumi Kawasaki, Takuya Sueyoshi, Kouji Kobiyama, Ken J Ishii, Jian Zou, Shizuo Akira, Tadashi Matsuda and Taro Kawai

    J Immunol, 198 (4), 1649-1659, 2017.
19. Identification of an atypical monocyte and committed progenitor involved in fibrosis.

    Takashi Satoh, Katsuhiro Nakagawa, Fuminori Sugihara, Ryusuke Kuwahara, Motooki Ashihara, Fumihiro Yamane, Yosuke Minowa, Kiyoharu Fukushima, Isao Ebina, Yoshichika Yoshioka, Atsushi Kumanogoh and Shizuo Akira

    Nature, 541 (7635), 96-101, 2017.
20. G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.

    Yuko Kawano, Chie Fukui, Masakazu Shinohara, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Tomoyuki Furuyashiki, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui and Yoshio Katayama

    Blood, 129 (5), 587-597, 2017.

Link

Department of Host Defense

Research Institute for Microbial Diseases, Osaka University