Department of Cell Biology

Staff:

Professor

Eisuke Mekada, Ph.D.

Associate Professor

Ryo Iwamoto, Ph.D.

Subjects:

1. The role of heparin-binding EGF-like growth factor in development.
2. The mode of actions of membrane-anchored growth factors.
3. Ectodomain shedding mechanism of EGF family growth factor.
4. Physiological role of CD9 and the tetraspanin family proteins.

Papers published in 2017

1. ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.

   Ryo Iwamoto, Naoki Mine, Hiroto Mizushima and Eisuke Mekada

   J Cell Sci, 130 (7), 1321-1332, 2017.
2. Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis.

   Takuya Murata, Eisuke Mekada and Robert M Hoffman

   Cell Cycle, 16 (6), 533-535, 2017.
3. BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study.

   Shingo Miyamoto, Fusanori Yotsumoto, Taeko Ueda, Tatsuya Fukami, Ayako Sanui, Kohei Miyata, Sung Ouk Nam, Satoshi Fukagawa, Takahiro Katsuta, Miyako Maehara, Haruhiko Kondo, Daisuke Miyahara, Kyoko Shirota, Toshiyuki Yoshizato, Masahide Kuroki, Hiroaki Nishikawa, Keijiro Saku, Yoshio Tsuboi, Kenji Ishitsuka, Yasushi Takamatsu, Kazuo Tamura, Akira Matsunaga, Toru Hachisuga, Shinsuke Nishino, Takashi Odawara, Kazuhiro Maeda, Sadao Manabe, Toyokazu Ishikawa, Yoshinobu Okuno, Minako Ohishi, Tomoya Hikita, Hiroto Mizushima, Ryo Iwamoto and Eisuke Mekada

   BMC Cancer, 17 (1), 89, 2017.

Link

Department of Cell Biology

Research Institute for Microbial Diseases, Osaka University