Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories

Staff:

Specially Appointed Associate Professor

Yasuo Yoshioka, Ph.D.

Specially Appointed Researcher

Hideki Takahashi

Kazuki Misato

Technical Staff

Tomomi Sakamoto

Undergraduate Student

Yuki Kanai

Yuki Shirai

Subjects:

1. Development of vaccine adjuvant using comprehensive screening methods
2. Development of antigen delivery carriers and adjuvants using nanotechnology
3. Development of vaccines for infectious diseases using our developed adjuvants and delivery carriers

Papers published in 2016

1. Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes.

   Michihiko Aoyama, Katsutomo Hata, Kazuma Higashisaka, Kazuya Nagano, Yasuo Yoshioka and Yasuo Tsutsumi

   Biochem Biophys Res Commun, 480 (4), 690-695, 2016.
2. Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity.

   Toshiro Hirai, Yasuo Yoshioka, Asako Udaka, Eiichiro Uemura, Tomoyuki Ohe, Hisae Aoshima, Jian-Qing Gao, Ken Kokubo, Takumi Oshima, Kazuya Nagano, Kazuma Higashisaka, Tadahiko Mashino and Yasuo Tsutsumi

   Nanoscale Res Lett, 11 (1), 449, 2016.
3. Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice.

   Yuki Morishita, Yasuo Yoshioka, Yuya Takimura, Yuki Shimizu, Yuki Namba, Nao Nojiri, Takuya Ishizaka, Keizo Takao, Fumiyoshi Yamashita, Kazuhiro Takuma, Yukio Ago, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-Ichi Tsunoda, Shigeru Saito, Toshio Matsuda, Mitsuru Hashida, Tsuyoshi Miyakawa, Kazuma Higashisaka and Yasuo Tsutsumi

   ACS Nano, 10 (9), 8180-8191, 2016.
4. Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice.

   Toshiro Hirai, Yasuo Yoshioka, Natsumi Izumi, Ko-Ichi Ichihashi, Takayuki Handa, Nobuo Nishijima, Eiichiro Uemura, Ko-Ichi Sagami, Hideki Takahashi, Manami Yamaguchi, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-Ichi Tsunoda, Ken J Ishii, Kazuma Higashisaka and Yasuo Tsutsumi

   Nat Nanotechnol, 11 (9), 808-816, 2016.
5. Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation.

   Akimitsu Miyawaki, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Shin-Ichi Tsunoda, Masanori Obana, Makiko Maeda, Hiroyuki Nakayama, Yasuo Yoshioka, Yasuo Tsutsumi and Yasushi Fujio

   Am J Physiol Heart Circ Physiol, 311 (2), H476-486, 2016.
6. High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis.

   T Hirai, Y Yoshioka, H Takahashi, T Handa, N Izumi, T Mori, E Uemura, N Nishijima, K Sagami, M Yamaguchi, S Eto, K Nagano, H Kamada, S Tsunoda, K J Ishii, K Higashisaka and Y Tsutsumi

   Clin Exp Allergy, 46 (7), 992-1003, 2016.

Link

Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories

Research Institute for Microbial Diseases, Osaka University