Department of Signal Transduction

Staff:

Professor

Nobuyuki Takakura, M.D., Ph.D.

Assistant Professor

Hiroyasu Kidoya, Ph.D.

Hisamichi Naito, M.D., Ph.D.

Specially Appointed Researcher

Daishi Yamakawa, Ph.D.

Weizhen Jia, Ph.D.

Taku Wakabayashi, M.D., Ph.D.

Graduate Student

Kazuhiro Takara

Zhang Li

Ryu Kanzaki

Fumitaka Muramatsu

Keitaro Yamane

Tomoko Kosaka

Hironori Yoshida

Daisuke Eino

Miku Kitta

Yumiko Hayashi

Shoko Hosojima

Research Student

Nobuaki Ooto

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Papers published in 2016

1. Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats.

   Masafumi Hiramatsu, Tomohito Hishikawa, Koji Tokunaga, Hiroyasu Kidoya, Shingo Nishihiro, Jun Haruma, Tomohisa Shimizu, Yuji Takasugi, Yukei Shinji, Kenji Sugiu, Nobuyuki Takakura and Isao Date

   J Neurosurg, , 1-8, 2016.
2. Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells.

   Keitaro Yamane, Hisamichi Naito, Taku Wakabayashi, Hironori Yoshida, Fumitaka Muramatsu, Tomohiro Iba, Hiroyasu Kidoya and Nobuyuki Takakura

   Sci Rep, 6, 30941, 2016.
3. PSF1 (Partner of SLD Five 1) is a Prognostic Biomarker in Patients with Non-small Cell Lung Cancer Treated with Surgery Following Preoperative Chemotherapy or Chemoradiotherapy.

   Ryu Kanzaki, Hisamichi Naito, Kazuyoshi Kise, Kazuhiro Takara, Daisuke Eino, Masato Minami, Yasushi Shintani, Soichiro Funaki, Tomohiro Kawamura, Toru Kimura, Meinoshin Okumura and Nobuyuki Takakura

   Ann Surg Oncol, 23 (12), 4093-4100, 2016.
4. Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance.

   Hisamichi Naito, Taku Wakabayashi, Hiroyasu Kidoya, Fumitaka Muramatsu, Kazuhiro Takara, Daisuke Eino, Keitaro Yamane, Tomohiro Iba and Nobuyuki Takakura

   Cancer Res, 76 (11), 3200-3210, 2016.
5. Tumor microenvironment for cancer stem cells.

   Kazuyoshi Kise, Yumi Kinugasa-Katayama and Nobuyuki Takakura

   Adv Drug Deliv Rev, 99 (Pt B), 197-205, 2016.
6. Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors.

   Supranee Phanthanawiboon, Kriengsak Limkittikul, Yusuke Sakai, Nobuyuki Takakura, Masayuki Saijo and Takeshi Kurosu

   PLoS One, 11 (2), e0148564, 2016.
7. Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy.

   Li Zhang, Kazuhiro Takara, Daishi Yamakawa, Hiroyasu Kidoya and Nobuyuki Takakura

   Cancer Sci, 107 (1), 36-44, 2016.

Link

Department of Signal Transduction

Research Institute for Microbial Diseases, Osaka University