Research Promotion Group, Combined Program on Microbiology and Immunology

Staff:

Associate Professor

Yoshiko Murakami, M.D., Ph.D.

Subjects:

1. Investigation of the pathogenesis of PNH;
2. Investigation of the pathogeneses of inherited glycosylphosphatidylinositol(GPI) deficiencies(IGD)
3. Molecular biology of biosynthesis pathway of GPI-anchored proteins.

Papers published in 2016

1. A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.

   Gun-Hee Lee, Morihisa Fujita, Katsuyoshi Takaoka, Yoshiko Murakami, Yoshitaka Fujihara, Noriyuki Kanzawa, Kei-Ichi Murakami, Eriko Kajikawa, Yoko Takada, Kazunobu Saito, Masahito Ikawa, Hiroshi Hamada, Yusuke Maeda and Taroh Kinoshita

   J Cell Biol, 215 (5), 705-718, 2016.
2. Rare Noncoding Mutations Extend the Mutational Spectrum in the PGAP3 Subtype of Hyperphosphatasia with Mental Retardation Syndrome.

   Alexej Knaus, Tomonari Awaya, Ingo Helbig, Zaid Afawi, Manuela Pendziwiat, Jubran Abu-Rachma, Miles D Thompson, David E Cole, Steve Skinner, Fran Annese, Natalie Canham, Michal R Schweiger, Peter N Robinson, Stefan Mundlos, Taroh Kinoshita, Arnold Munnich, Yoshiko Murakami, Denise Horn and Peter M Krawitz

   Hum Mutat, 37 (8), 737-744, 2016.
3. A novel mutation in PIGW causes glycosylphosphatidylinositol deficiency without hyperphosphatasia.

   Max Hogrebe, Yoshiko Murakami, Martin Wild, Martina Ahlmann, Saskia Biskup, Konstanze Hörtnagel, Marianne Grüneberg, Janine Reunert, Tobias Linden, Taroh Kinoshita and Thorsten Marquardt

   Am J Med Genet A, 170 (12), 3319-3322, 2016.
4. A novel PIGN mutation and prenatal diagnosis of inherited glycosylphosphatidylinositol deficiency.

   Taku Nakagawa, Mariko Taniguchi-Ikeda, Yoshiko Murakami, Shota Nakamura, Daisuke Motooka, Tomomi Emoto, Wataru Satake, Masahiro Nishiyama, Daisaku Toyoshima, Naoya Morisada, Satoshi Takada, Shinya Tairaku, Nobuhiko Okamoto, Ichiro Morioka, Hiroki Kurahashi, Tatsushi Toda, Taroh Kinoshita and Kazumoto Iijima

   Am J Med Genet A, 170 (1), 183-188, 2016.

Link

Research Institute for Microbial Diseases, Osaka University