Department of Molecular Virology

Staff:

Professor

Yoshiharu Matsuura, D.V.M., Ph.D.

Assistant Professor

Toru Okamoto, Ph.D.

Takasuke Fukuhara, M.D., Ph.D.

JSPS Postdoctoral Fellowship

Tomokazu Tamura, D.V.M., Ph.D.

Specially Appointed Researcher

Chikako Ono, Ph.D.

Postdoctoral fellow

Satomi Yamamoto, Ph.D.

Graduate Student

Tatsuya Suzuki

Hiroyuki Mori

Shinnji Kusakabe

Asuka Sato

Makoto Tokunaga

Kentaro Uemura

Junki Hirano

Yuzy Fauzyah

Research Student

Ryoichi Shima

Subjects:

1. Studies on hepatitis C virus.
2. Studies on Japanese encephalitis virus.
3. Studies on hepatitis B virus.
4. Development of viral vectors.

Papers published in 2016

1. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.

   Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike and Yoshiharu Matsuura

   Nat Commun, 7, 11379, 2016.
2. Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus.

   Satomi Yamamoto, Takasuke Fukuhara, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Mai Shiokawa, Hiroyuki Mori, Masami Wada, Ryoichi Shima, Toru Okamoto, Nobuhiko Hiraga, Ryosuke Suzuki, Kazuaki Chayama, Takaji Wakita and Yoshiharu Matsuura

   PLoS Pathog, 12 (5), e1005610, 2016.
3. Human cathelicidin compensates for the role of apolipoproteins in the infectious particle formation of HCV.

   Francesc Puig-Basagoiti, Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Satomi Yamamoto, Hiroyuki Mori, Takeshi Kurihara, Toru Okamoto, Hideki Aizaki and Yoshiharu Matsuura

   J Virol, 90 (19), 8464-8477, 2016.
4. Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx.

   Takahisa Kouwaki, Toru Okamoto, Ayano Ito, Yukari Sugiyama, Kazuo Yamashita, Tatsuya Suzuki, Shinji Kusakabe, Junki Hirano, Takasuke Fukuhara, Atsuya Yamashita, Kazunobu Saito, Daisuke Okuzaki, Koichi Watashi, Masaya Sugiyama, Sachiyo Yoshio, Daron M Standley, Tatsuya Kanto, Masashi Mizokami, Kohji Moriishi and Yoshiharu Matsuura

   J Virol, 90 (7), 3530-3542, 2016.
5. Reverse Genetics for Fusogenic Bat-Borne Orthoreovirus Associated with Acute Respiratory Tract Infections in Humans: Role of Outer Capsid Protein σC in Viral Replication and Pathogenesis.

   Takahiro Kawagishi, Yuta Kanai, Hideki Tani, Masayuki Shimojima, Masayuki Saijo, Yoshiharu Matsuura and Takeshi Kobayashi

   PLoS Pathog, 12 (2), e1005455, 2016.
6. Production of hepatitis E virus-like particles presenting multiple foreign epitopes by co-infection of recombinant baculoviruses.

   Ryoichi Shima, Tian Cheng Li, Yutaka Sendai, Chikako Kataoka, Yoshio Mori, Takayuki Abe, Naokazu Takeda, Toru Okamoto and Yoshiharu Matsuura

   Sci Rep, 6, 21638, 2016.
7. Unique Requirement for ESCRT Factors in Flavivirus Particle Formation on the Endoplasmic Reticulum.

   Keisuke Tabata, Masaru Arimoto, Masashi Arakawa, Atsuki Nara, Kazunobu Saito, Hiroko Omori, Arisa Arai, Tomohiro Ishikawa, Eiji Konishi, Ryosuke Suzuki, Yoshiharu Matsuura and Eiji Morita

   Cell Rep, 16 (9), 2339-2347, 2016.
8. Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.

   Tomohisa Tanaka, Kaori Okuyama-Dobashi, Shuko Murakami, Wenjia Chen, Toru Okamoto, Keiji Ueda, Takamitsu Hosoya, Yoshiharu Matsuura, Akihide Ryo, Yasuhito Tanaka, Masatoshi Hagiwara and Kohji Moriishi

   Antiviral Res, 133, 156-164, 2016.
9. Is the optimal pH for membrane fusion in host cells by avian influenza viruses related to host range and pathogenicity?

   Masatoshi Okamatsu, Yurie Motohashi, Takahiro Hiono, Tomokazu Tamura, Kazuki Nagaya, Keita Matsuno, Yoshihiro Sakoda and Hiroshi Kida

   Arch Virol, 161 (8), 2235-2242, 2016.
10. Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA.

    Kazuya Masuda, Barry Ripley, Kishan Kumar Nyati, Praveen Kumar Dubey, Mohammad Mahabub-Uz Zaman, Hamza Hanieh, Mitsuru Higa, Kazuo Yamashita, Daron M Standley, Tsukasa Mashima, Masato Katahira, Toru Okamoto, Yoshiharu Matsuura, Osamu Takeuchi and Tadamitsu Kishimoto

    J Exp Med, 213 (4), 605-619, 2016.
11. Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.

    Sachiyo Yoshio, Masaya Sugiyama, Hirotaka Shoji, Yohei Mano, Eiji Mita, Toru Okamoto, Yoshiharu Matsuura, Alato Okuno, Osamu Takikawa, Masashi Mizokami and Tatsuya Kanto

    Hepatology, 63 (1), 83-94, 2016.

Link

Department of Molecular Virology

Research Institute for Microbial Diseases, Osaka University