Department of Molecular Genetics

Staff:

Professor

Hiroshi Nojima, Ph.D.

Associate Professor

Norikazu Yabuta, Ph.D.

Assistant Professor (SUP)

Daisuke Okuzaki, Ph.D.

Specially Appointed Researcher

Satomi Mukai, Ph.D.

Yoko Naito,Ph.D.

Researcher

Yuki Sekine

Kyoko Nakajima

Research Collaborator

Daisaku Miura, Ph.D.

Graduate Student

Kosuke Torigata

Katsuma Matsuura

Wang Mian

Kaori Ota

Chie Ota

Yorika Kato

Subjects:

1. Molecular mechanisms regulating the cell cycle (checkpoint) in mammalian cells.
2. Molecular mechanisms modulating the malignancy of cancer cells.
3. Application of a new technique (Leuko Catch) to RNA diagnosis.

Papers published in 2016

1. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.

   Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, Tatsusada Okuno, Satoshi Nojima, Sujin Kang, Daisuke Ito, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuichi Mitsui, Natsuki Sakurai, Hana Sarashina-Kida, Masayuki Nishide, Yohei Maeda, Hyota Takamatsu, Daisuke Okuzaki, Masaki Yamada, Masato Okada and Atsushi Kumanogoh

   Nat Commun, 7, 13130, 2016.
2. Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2.

   Shouichi Ohno, Jun-Ichiro Ikeda, Yoko Naito, Daisuke Okuzaki, Towa Sasakura, Kohshiro Fukushima, Yukihiro Nishikawa, Kaori Ota, Yorika Kato, Mian Wang, Kosuke Torigata, Takashi Kasama, Toshihiro Uchihashi, Daisaku Miura, Norikazu Yabuta, Eiichi Morii and Hiroshi Nojima

   Sci Rep, 6, 39091, 2016.
3. Large tumor suppressors 1 and 2 regulate Aurora-B through phosphorylation of INCENP to ensure completion of cytokinesis.

   Norikazu Yabuta, Kaori Yoshida, Satomi Mukai, Yorika Kato, Kosuke Torigata and Hiroshi Nojima

   Heliyon, 2 (7), e00131, 2016.
4. AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol.

   Radhika Jagannathan, Gregory V Schimizzi, Kun Zhang, Andrew J Loza, Norikazu Yabuta, Hitoshi Nojima and Gregory D Longmore

   Mol Cell Biol, 36 (20), 2526-2542, 2016.
5. LATS2 Positively Regulates Polycomb Repressive Complex 2.

   Kosuke Torigata, Okuzaki Daisuke, Satomi Mukai, Akira Hatanaka, Fumiharu Ohka, Daisuke Motooka, Shota Nakamura, Yasuyuki Ohkawa, Norikazu Yabuta, Yutaka Kondo and Hiroshi Nojima

   PLoS One, 11 (7), e0158562, 2016.
6. IFI27 Is a Useful Genetic Marker for Diagnosis of Immunoglobulin A Nephropathy and Membranous Nephropathy Using Peripheral Blood.

   Yasuyuki Nagasawa, Daisuke Okuzaki, Eri Muso, Ryohei Yamamoto, Maki Shinzawa, Yukako Iwasaki, Hirotsugu Iwatani, Takeshi Nakanishi, Yoshitaka Isaka and Hiroshi Nojima

   PLoS One, 11 (4), e0153252, 2016.
7. Interleukin-18-deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis.

   Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara-Otani, Yuko Watanabe, Momoko Yoshida, Kaoru Ikubo, Daisuke Okuzaki, Yosif El-Darawish, Wen Li, Keiji Nakasho, Hiroshi Nojima, Hiromichi Yamanishi, Tetsu Hayakawa, Haruki Okamura and Hisato Matsunaga

   Transl Res, 173, 101-114.e7, 2016.
8. Identification of a human intestinal myeloid cell subset that regulates gut homeostasis.

   Soumik Barman, Hisako Kayama, Daisuke Okuzaki, Takayuki Ogino, Hideki Osawa, Hiroshi Matsuno, Tsunekazu Mizushima, Masaki Mori, Junichi Nishimura and Kiyoshi Takeda

   Int Immunol, 28 (11), 533-545, 2016.
9. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

   Kosuke Fujimoto, Makoto Kinoshita, Hiroo Tanaka, Daisuke Okuzaki, Yosuke Shimada, Hisako Kayama, Ryu Okumura, Yoki Furuta, Masashi Narazaki, Atsushi Tamura, Shigetsugu Hatakeyama, Masahito Ikawa, Kiichiro Tsuchiya, Mamoru Watanabe, Atsushi Kumanogoh, Sachiko Tsukita and Kiyoshi Takeda

   Mucosal Immunol, 10 (2), 446-459, 2016.
10. Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury.

    Takao Sudo, Takafumi Yokota, Daisuke Okuzaki, Tomoaki Ueda, Michiko Ichii, Tomohiko Ishibashi, Tomomi Isono, Yoko Habuchi, Kenji Oritani and Yuzuru Kanakura

    PLoS One, 11 (4), e0154189, 2016.
11. Transcriptional Profile during Deoxycholate-Induced Sporulation in a Clostridium perfringens Isolate Causing Foodborne Illness.

    Mayo Yasugi, Daisuke Okuzaki, Ritsuko Kuwana, Hiromu Takamatsu, Masaya Fujita, Mahfuzur R Sarker and Masami Miyake

    Appl Environ Microbiol, 82 (10), 2929-2942, 2016.
12. Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx.

    Takahisa Kouwaki, Toru Okamoto, Ayano Ito, Yukari Sugiyama, Kazuo Yamashita, Tatsuya Suzuki, Shinji Kusakabe, Junki Hirano, Takasuke Fukuhara, Atsuya Yamashita, Kazunobu Saito, Daisuke Okuzaki, Koichi Watashi, Masaya Sugiyama, Sachiyo Yoshio, Daron M Standley, Tatsuya Kanto, Masashi Mizokami, Kohji Moriishi and Yoshiharu Matsuura

    J Virol, 90 (7), 3530-3542, 2016.
13. Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2.

    Makoto Fujiwara, Takuo Kubota, Wei Wang, Yasuhisa Ohata, Kohji Miura, Taichi Kitaoka, Daisuke Okuzaki, Noriyuki Namba, Toshimi Michigami, Yasuji Kitabatake and Keiichi Ozono

    Bone, 85, 91-98, 2016.
14. Down-Regulation of microRNA-132 is Associated with Poor Prognosis of Colorectal Cancer.

    Yukako Mokutani, Mamoru Uemura, Koji Munakata, Daisuke Okuzaki, Naotsugu Haraguchi, Hidekazu Takahashi, Junichi Nishimura, Taishi Hata, Kohei Murata, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori and Hirofumi Yamamoto

    Ann Surg Oncol, 23 (Supplement 5), 599-608, 2016.
15. Microarray and whole-exome sequencing analysis of familial Behçet's disease patients.

    Daisuke Okuzaki, Kazuyuki Yoshizaki, Toshio Tanaka, Toru Hirano, Kohshiro Fukushima, Takanori Washio and Hiroshi Nojima

    Sci Rep, 6, 19456, 2016.
16. Requirement of CXCL12-CXCR7 signaling for CD20(-) CD138(-) double-negative population in lymphoplasmacytic lymphoma.

    Naoki Wada, Jun-Ichiro Ikeda, Satoshi Nojima, Shin-Ichiro Tahara, Kenji Ohshima, Daisuke Okuzaki and Eiichi Morii

    Lab Invest, 96 (5), 517-525, 2016.
17. MicroRNA-27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling.

    Rei Matsuyama, Daisuke Okuzaki, Masato Okada and Chitose Oneyama

    Cancer Sci, 107 (1), 28-35, 2016.

Link

Research Institute for Microbial Diseases, Osaka University