Department of Immunoparasitology

Staff:

Professor

Masahiro Yamamoto, Ph.D.

Associate Professor

Miwa Sasai, Ph.D.

Specially Appointed Assistant Professor

Hironori Bando, Ph.D.

Graduate Student

Naoya Sakaguchi

Ariel Pradipta, M.D.

Subjects:

1. Negative regulation of interferon-g-induced cell-autonomous immunity to Toxoplasma by RabGDIα
2. Involvement of p62/Sqstm1 in interferon-g-dependent Toxoplasama antigen presentation
3. Essential role of GBPs in AIM2 inflammasome activation by Francisella

Papers published in 2016

1. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

   Si Ming Man, Rajendra Karki, Miwa Sasai, David E Place, Sannula Kesavardhana, Jamshid Temirov, Sharon Frase, Qifan Zhu, R K Subbarao Malireddi, Teneema Kuriakose, Jennifer L Peters, Geoffrey Neale, Scott A Brown, Masahiro Yamamoto and Thirumala-Devi Kanneganti

   Cell, 167 (2), 382-396.e17, 2016.
2. The P2X4 receptor is required for neuroprotection via ischemic preconditioning.

   Tomohiko Ozaki, Rieko Muramatsu, Miwa Sasai, Masahiro Yamamoto, Yoshiaki Kubota, Toshiyuki Fujinaka, Toshiki Yoshimine and Toshihide Yamashita

   Sci Rep, 6, 25893, 2016.
3. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.

   Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike and Yoshiharu Matsuura

   Nat Commun, 7, 11379, 2016.
4. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia.

   Ryu Okumura, Takashi Kurakawa, Takashi Nakano, Hisako Kayama, Makoto Kinoshita, Daisuke Motooka, Kazuyoshi Gotoh, Taishi Kimura, Naganori Kamiyama, Takashi Kusu, Yoshiyasu Ueda, Hong Wu, Hideki Iijima, Soumik Barman, Hideki Osawa, Hiroshi Matsuno, Junichi Nishimura, Yusuke Ohba, Shota Nakamura, Tetsuya Iida, Masahiro Yamamoto, Eiji Umemoto, Koichi Sano and Kiyoshi Takeda

   Nature, 532 (7597), 117-121, 2016.

Link

Department of Immunoparasitology

Research Institute for Microbial Diseases, Osaka University